Diltiazem

Description

Diltiazem is a calcium channel blocker which is used to control blood pressure and managing angina. The medicine should be taken in conjunction with a proper diet and regular exercise. Do not take if you are allergic to this medicine.

Side effects

Major & minor side effects for Diltiazem

  • Body pain
  • Cough
  • Fever
  • Chest discomfort
  • Headache
  • Diarrhea
  • Swelling of the hands, ankles, feet, or lower legs
  • Sneezing
  • Acid or sour stomach
  • Constipation
  • Muscle pain
  • Skin rash

Uses of Diltiazem

What is it prescribed for?

  • Hypertension
  • Angina Pectoris Prophylaxis
  • Atrial Fibrillation
  • Supraventricular Tachycardia
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed in 2 to 4 hours for an immediate release tablet, 11 to 18 hours for an extended release tablet and 10 to 14 hours for an extended release capsule.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 9 to 12 hours for an immediate release tablet, 12 to 24 hours for an extended release tablet, 15 to 30 hours for an extended release capsule, 9 to 12 hours for a single intravenous dose, 12 to 15 hours for an infusion.
  • Safe with alcohol?
    Consumption of alcohol should be avoided while taking this medicine, especially when you start taking the medicine or a change its dosage. Symptoms like headache, dizziness, change in pulse or heart rate should be reported to the doctor.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for pregnant women. Use under the supervision of the doctor, only if clinical condition clearly requires the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for breastfeeding women. Use only if clearly needed under the doctor's supervision. Monitoring of blood pressure is necessary.

Allergy

Avoid if you have a known allergy to Diltiazem or any medicine belongs to the class calcium channel blockers.

Hypotension

This medicine is not recommended in the patients with the systolic blood pressure less than 90 mm Hg.

Acute myocardial infarction

This medicine is not recommended in the patients with known case of myocardial infarction.

Sick sinus syndrome

This medicine is not recommended in the patients with sick sinus syndrome except in the presence of a functioning ventricular pacemaker.
Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women. Use under the supervision of the doctor, only if clinical condition clearly requires the use of this medicine.

Breast-feeding

This medicine is not recommended for breastfeeding women. Use only if clearly needed under the doctor's supervision. Monitoring of blood pressure is necessary.
General warnings

Hypotension

Diltiazem may further decrease the blood pressure which results in symptomatic hypotension. Frequent monitoring of blood pressure is necessary. Dose adjustments are to be made based on the clinical condition.

Cardiac Conduction

Diltiazem may cause slow heart rates and this effect is more in the patients who are on beta-blockers or digitalis. Frequent monitoring of heart function is necessary. Dose adjustments are to be made based on the clinical condition.

Impaired liver function

Diltiazem may cause a mild elevation in the liver enzymes like alkaline phosphatase, LDH, SGOT, SGPT. These levels return to normal once the medicine is discontinued. Close monitoring of liver function tests is necessary. Dose adjustments are to be made based on the clinical condition.

Skin reaction

Diltiazem may cause rare but severe skin reactions like Stevens-Johnson syndrome, toxic epidermal necrolusis, erythema multiforme and/or exfoliative dermatitis. Any symptoms of skin rash or itching should be reported to the doctor.

Pediatric use

The safety and efficacy of Diltiazem is not established in the children.

Missed Dose

The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for your next dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Consumption of alcohol while taking Diltiazem may cause an additional lowering of the blood pressure. This may result in severe complication over time.

Instructions

Consumption of alcohol should be avoided while taking this medicine, especially when you start taking the medicine or a change its dosage. Symptoms like headache, dizziness, change in pulse or heart rate should be reported to the doctor.
Interaction with Medicine

Carbamazepine

Itraconazole

Ethinyl Estradiol

Atorvastatin

Disease interactions

Aortic Stenosis

Diltiazem is not recommended in the patients with aortic stenosis as it may worsen the myocardial oxygen balance.
Food interactions
Information not available.
Lab interactions
Information not available.
You should carefully follow all instructions on the label. The duration and amount of medicine consumed should be as prescribed by the doctor. It can be taken with food or after food. An adequate amount of water should be consumed to minimize the irritation caused in the stomach.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by inhibiting the influx of calcium into the muscles and causes relaxation of the muscles.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Calcium channel blocking agents

Schedule

Schedule H

[Internet]. 2017 [cited 6 April 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/30670

DailyMed - diltiazem hydrochloride capsule, extended release [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 6 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d6a81f9f-3a51-4e86-aeb3-8352186b3528#s13

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 6 April 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 6 April 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~G636cu:4

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Information on this page was last updated on 16 Nov 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.