Diloxanide Furoate

Description

Diloxanide Furoate is used as a primary agent in the treatment of asymptomatic intestinal amebiasis caused by Entamoeba histolytica. It may also be used in a combination with other medicines to treat invasive or extraintestinal forms of amebiasis.

Side effects

Major & minor side effects for Diloxanide Furoate

  • Severe skin rash and hives
  • Difficulty in breathing
  • Flatulence
  • Nausea or Vomiting
  • Abdominal pain and cramps
  • Loss of appetite
  • Diarrhea
  • Headache
  • Dry mouth

Uses of Diloxanide Furoate

What is it prescribed for?

  • Intestinal amoebiasis
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed within 2 hours of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 6 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment with this medicine after evaluating the potential benefits and risks. It is advised to defer treatment, when possible, until after the first trimester of pregnancy.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment with this medicine after evaluating the potential benefits and risks.

Allergy

This medicine is not recommended for use in patients with a known allergy to diloxanide or any other inactive ingredient present in the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment with this medicine after evaluating the potential benefits and risks. It is advised to defer treatment, when possible, until after the first trimester of pregnancy.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment with this medicine after evaluating the potential benefits and risks.
General warnings

Other medicines

Diloxanide Furoate may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Use in children

This medicine is not recommended for use in children below 2 years of age and in patients who weigh less than 25 kg since the safety and efficacy of use are not clinically established for such patients.

Use in elderly

This medicine should be used with caution and monitoring in elderly patients since the risk of adverse effects is significantly high. Replacement with a suitable alternative may be necessary for some patients based on the clinical condition.

Dose regimen

Treatment course with this medicine is regarded as successful if stools remain free of Entamoeba histolytica for one month. Your doctor may examine several specimens while evaluating the response to treatment.

Completion of dose course

It is recommended to take this medicine for the entire prescribed duration even when symptoms improve or resolve. Failure to do so may result in drug resistance, making the treatment of subsequent infections very difficult.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as advised by your doctor. Do not take in larger or smaller amounts than advised. It is recommended to take this medicine at the same time every day. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by interfering with certain vital functions in the protozoal cell, causing the death of the organism.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Systemic anti-protozoals

Schedule

Schedule H

[Internet]. Deuralijanta.com. 2018 [cited 26 September 2018]. Available from:

http://www.deuralijanta.com/product/division1/PROTOGYL.pdf

[Internet]. Vardgivarwebb.regionostergotland.se. 2018 [cited 26 September 2018]. Available from:

https://vardgivarwebb.regionostergotland.se/pages/233476/furamide%202013.pdf

Diloxanide [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 26 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Diloxanide#section=Top

Diloxanide - DrugBank [Internet]. Drugbank.ca. 2018 [cited 26 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB08792

[Internet]. Apps.who.int. 2018 [cited 26 September 2018]. Available from:

http://apps.who.int/medicinedocs/en/d/Jh2922e/2.1.2.html#Jh2922e.2.1.2

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Information on this page was last updated on 9 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.