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Diavas 2 Tablet

Manufactured byMicro Labs Ltd.
ContainsMetformin (500 mg) + Glimepiride (2 mg) + Atorvastatin (10 mg)
Description

Diavas 2 Tablet is a combination medicine used for the treatment of patients suffering from type 2 diabetes mellitus and dyslipidemia. Patients are advised to follow a strict exercise and diet regimen along with this medicine to get the best possible effect. This medicine is not recommended for use in patients less than 18 years of age.

Side effects

Major & minor side effects for Diavas 2 Tablet

  • Nausea and vomiting
  • Diarrhea
  • Abdominal pain
  • Hypoglycemia
  • Lactic Acidosis
  • Weakness
  • Chest discomfort
  • Headache
  • Runny Nose
  • Belching and Heartburn
  • Swollen joints
  • Cough
  • Difficulty in swallowing
  • Impaired liver function
  • Joint pain
  • Muscle pain
  • Difficulty in breathing
  • Insomnia

Uses of Diavas 2 Tablet

What is it prescribed for?

  • Type II Diabetes Mellitus with dyslipidemia
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The anti-diabetic effect of this medicine can be observed within 1 to 3 hours of administration of the dose. The anti-dyslipidemic effect of this medicine is cumulative and may take up to 3 to 5 days to show its results.
  • How long do the effects of this medicine last?
    The anti-diabetic effect of this medicine lasts for an average duration of 24 hours. The anti-dyslipidemic effect of this medicine may last for an average duration of 3 to 4 days after the onset of action.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Severe kidney impairment

This medicine is not recommended for use in patients with a severe impairment of kidney function due to the increased risk of serious adverse effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to atorvastatin, glimepiride, other sulphonamide derivatives, metformin, or any other inactive ingredients present along with these medicines.

Metabolic Acidosis

This medicine is not recommended for use in patients with metabolic acidosis since it may worsen the patient's condition.

Liver disease

This medicine is not recommended for use in patients with active liver diseases indicated by high levels of transaminases since it may worsen the patient's condition.

Diabetic ketoacidosis

This medicine is not recommended for use in patients with diabetic ketoacidosis due to the increased risk of worsening of the patient's condition.

Type I Diabetes mellitus

This medicine is not recommended for use in patients suffering from Type I diabetes mellitus since it is not effective in treating this condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Stress

Use of this medicine should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.

Diarrhea

This medicine may cause diarrhea when therapy is initiated. In most cases, diarrhea subsides by itself. Contact your doctor if the problem persists for longer durations. Therapy may need to be discontinued in some cases based on the clinical condition.

Cognitive impairment

This medicine may cause forgetfulness, memory loss, confusion, etc. in some patients. These side effects are reversible and usually disappear once the medicine is discontinued.

Muscle degradation and Rhabdomyolysis

This medicine may cause muscle breakdown and rhabdomyolysis in some patients, a condition which can be fatal. This may cause symptoms such as severe tiredness and weakness. This risk is especially higher in the elderly population and in patients with kidney diseases, hypothyroidism, and active muscle disorders. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Stroke

This medicine is not recommended for use in patients recovering from a stroke since it may worsen the patient's condition.

Hypoglycemia

This medicine may cause hypoglycemia in some patients. This risk is especially higher in patients suffering from kidney diseases, malnourishment, pituitary gland diseases, etc. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments may be required based on the clinical condition. Your doctor may advise you to carry a sugar candy to counteract the effects of low blood sugar levels (hypoglycemia).

Fluid Retention and Edema

This medicine should be used with caution in patients with fluid retention and edema due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Weight gain

This medicine may cause a mild to moderate weight gain in some patients.

Change of medicines

You may experience some temporary side effects if there is a change in the current medications used for diabetes mellitus. This overlapping effect is because of the change from one medicine to another. Close monitoring of blood sugar levels is recommended in these cases.

Use in pediatrics

This medicine is not recommended for use in children and adolescents since the safety and efficacy of use are not clinically established.

Lactic Acidosis

This medicine may cause lactic acidosis, which may be fatal, in some patients. This risk is especially higher in patients suffering from heart diseases, kidney diseases, etc. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Interaction with Medicine

Amlodipine

Diclofenac

Estradiol

Gatifloxacin

Atazanavir

Cyclosporine

Azole antifungal agents

Rifampicin

Colesevelam

Iodinated Contrast Media

Aloe Vera

Macrolide antibiotics

Disease interactions

Vitamin B12 deficiency

This medicine should be used with extreme caution in patients with vitamin B12 deficiency since it may worsen the patient's condition. Appropriate vitamin B12 supplementation and dose adjustments may be required based on the clinical condition.

Rhabdomyolysis

This medicine is not recommended for use in patients with a known history of Rhabdomyolysis due to the increased risk of renal failure and death. Any symptoms such as muscle pain, weakness, or joint pain and swelling should be reported to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Hypoglycemia

This medicine should be administered with caution in patients prone to having low blood glucose level episodes. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Heart disease

This medicine should be administered with extreme caution in patients suffering from heart diseases or diseases of the blood vessels due to the increased risk of severe adverse effects. Close monitoring of heart function and vital signs is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney disease

This medicine should be used with extreme caution in patients with an impaired kidney function due to an increase in the risk of kidney injuries. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver disease

This medicine should be used with extreme caution in patients with an impaired liver function due to an increase in the risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hemolytic Anemia/G6PD Deficiency

This medicine is not recommended for use in patients with a history of Hemolytic Anemia or patients with G6PD deficiency due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of adverse effects such as dizziness, muscle pain, fever and chills, headache, swelling of hands and feet, vomiting, skin rash, etc.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. It is advised to take this medicine with meals. Your dose is likely to change over time based on therapeutic response and clinical condition. Regular monitoring of blood sugar levels is recommended during treatment with this medicine. You should always carry a sugar candy with you to counteract unexpected lowering of blood sugar levels. Do not change the dose or duration of use without consulting your doctor. This medicine will show better results if you maintain a strict exercise and diet regimen. Consult the doctor if you experience any undesirable side effects.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Metformin decreases absorption of glucose from the intestines and increases the action of insulin in the body. Glimepiride increases the secretion of insulin from the pancreas and also regulates the release of glucose from the liver. Atorvastatin reduces the level of cholesterol in the blood. This combination is thus effective in treating both diabetes mellitus and dyslipidemia.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antidiabetic combinations, Oral Biguanides, Sulfonylureas, Statins

Schedule

Schedule H

DailyMed - Metformin hcl tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 20 September 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d98aea3-35ba-447a-b88f-a5a20b612b2f

[Internet]. 2017 [cited 25 September 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.26348.latest.pdf

Metformin | C4H11N5 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 1 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/4091#section=Top

[Internet]. 2017 [cited 24 February 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf

[Internet]. 2017 [cited 23 February 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.2498.latest.pdf

Glimepiride - DrugBank [Internet]. Drugbank.ca. 2017 [cited 20 September 2017]. Available from:

https://www.drugbank.ca/drugs/DB00222
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Information on this page was last updated on 10 May 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.