Diatrizoic Acid

Description

Diatrizoic Acid is an injectable contrast medium or dye which contains iodine. It is used prior to x-rays to better visualize the areas of your body that doctors want to investigate. It is used alone or in a combination with other agents for a wide variety of diagnostic imaging methods, including angiography, urography, computed tomography, etc. It may also be used for imaging the gastrointestinal tract in patients allergic to barium.

Side effects

Major & minor side effects for Diatrizoic Acid

  • Nausea or vomiting
  • Diarrhea
  • Injection site pain and warmth
  • Severe skin rash and hives
  • Difficulty in breathing
  • Difficulty in swallowing
  • Swelling of the face, arms, hands, lower legs, or feet
  • Watery eyes
  • Headache and dizziness
  • Shaking and trembling of arms and feet
  • Agitation and anxiety
  • Bluish discoloration of lips, fingernails, palm, or hands
  • Fall in blood pressure
  • Fast/irregular heart beat
  • Convulsions (seizures)
  • Muscle weakness
  • Slurred speech
  • Vision disturbances
  • Hearing disturbances

Uses of Diatrizoic Acid

What is it prescribed for?

  • Diagnostic aid
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time taken by this medicine to show its effect is likely to vary based on the route of administration and the intended procedure for which the contrast media is being used.
  • Duration of effect
    The amount of time for which this medicine remains effective in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This dye is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of administration after evaluating the potential benefits and risks associated with the use of this contrast media.
  • Usage while breast-feeding?
    This dye is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of administration after evaluating the potential benefits and risks associated with the use of this contrast media.

Allergy

This dye or contrast media is not recommended for use if you have a known allergy to diatrizoic acid, salts of diatrizoic acid, iodine or iodine-containing contrast media, or any other ingredients present in the formulation.

Thyrotoxicosis

This medicine is not recommended for use in patients suffering from an uncontrolled thyrotoxicosis or excessive amounts of thyroid hormone in the body since it may worsen the patient's condition.

Heart insufficiency

This medicine is not recommended for use in patients suffering from a severe cardiac insufficiency marked by edema or swelling of different areas of the body and shortness of breath since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This dye is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of administration after evaluating the potential benefits and risks associated with the use of this contrast media.

Breast-feeding

This dye is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of administration after evaluating the potential benefits and risks associated with the use of this contrast media.
General warnings

Other medicines

Report the use of all other medicines including over the counter medicines, herbs, and supplements to the doctor prior to administration of this dye. This should be done to rule out the chances of a possible interaction.

Kidney disease

This dye should be used with caution in patients with an impairment of the normal kidney function. Appropriate clinical monitoring is advised for such patients. Replacement with a suitable alternative may be necessary in some cases based on the patient's clinical condition.

Liver disease

This dye should be used with caution in patients with an impairment of the normal liver function. Appropriate clinical monitoring is advised for such patients. Replacement with a suitable alternative may be necessary in some cases based on the patient's clinical condition.

Seizure disorder

This dye should be used with caution and monitoring in patients with an active or history of seizure disorders. Replacement with a suitable alternative may be necessary in some cases based on the patient's clinical condition.

Heart and blood vessel disorders

This dye should be used with extreme caution and monitoring in patients with a disease of the blood vessels or the heart. Replacement with a suitable alternative may be necessary in some cases based on the patient's clinical condition.

Thyroid gland disorder

This dye should be used with caution in patients with an active thyroid gland disorder or a swollen neck due to the enlargement of the thyroid gland. Close monitoring of the patient's condition or replacement with a suitable alternative may be necessary in some cases.

Multiple myeloma

This dye should be used with extreme caution in patients with a cancer of the blood called multiple myeloma. Replacement with a suitable alternative may be necessary in some cases based on the patient's clinical condition.

Dose and route of administration

The amount of dye to be administered and the appropriate route is to be determined by the doctor based on the intended diagnostic procedure and the patient's age, weight, and other parameters. You might be asked to prepare for the test by following certain specific procedures, communicated beforehand. Follow all the instructions given by your doctor.

Missed Dose

This dye is generally administered in a hospital or a diagnostic facility prior to or during a diagnostic procedure and hence, the likelihood of a missed dose is nill.

Overdose

This dye is generally administered in a hospital or a diagnostic facility prior to or during a diagnostic procedure and hence, the likelihood of a missed dose is very low. However, emergency medical treatment will be instituted by your doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Propranolol

Hydrochlorothiazide

Amlodipine

Digoxin

Methotrexate

Gentamicin

Dopamine

Lithium

Metformin

Diclofenac

Interleukins

Disease interactions

Pheochromocytoma

This dye should be used with extreme caution in patients with a tumor of the adrenal gland that caused excessive secretion of hormones (pheochromocytoma). Use is advised only in cases where the potential benefits outweigh the risks involved with use.

Congestive heart failure

This dye, particularly in the injectable form, should be used with caution and monitoring in patients with heart failure. It is advised to observe such patients for several hours following the administration of this dye.
Food interactions
Information not available.
Lab interactions
Information not available.
This dye is generally administered in a hospital or a diagnostic facility. You should follow all the instructions given by the doctor. The amount and route of administration are to be determined based on the intended diagnostic procedure. Report the use of all your current medicines as well as your medical conditions to the doctor before the administration of this dye.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by making the target area opaque to the X-rays. This, in turn, helps in producing high-quality contrast images on the film.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Ionic iodinated contrast media

Schedule

Schedule H

DailyMed - Diatrizoate sodium injection, solution [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 25 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=02ff6501-cccc-4f7d-9988-856d4e169b0e

Diatrizoate - DrugBank [Internet]. Drugbank.ca. 2018 [cited 25 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00271

Diatrizoic acid [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 25 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Diatrizoic_acid#section=Top

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Information on this page was last updated on 28 Sep 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.