Dexmedetomidine

Description

Dexmedetomidine is used for inducing sedation in patients who are under intensive medical care and mechanically ventilated. It is also be used for procedural sedation and should only be administered by a trained healthcare professional.

Side effects

Major & minor side effects for Dexmedetomidine

  • Headache
  • Dizziness
  • Dry mouth
  • Nausea and vomiting
  • Irregular heart beat
  • Slow breathing
  • Confusion
  • Low blood pressure
  • Constipation

Uses of Dexmedetomidine

What is it prescribed for?

  • Intensive care unit sedation (ICU sedation)
  • Procedural sedation
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 5 to 10 minutes after administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains effective in the body is subject to vary based on the administered dose and individuals.
  • Safe with alcohol?
    Alcohol should not be consumed prior to or after receiving this medicine since it may increase the risk of severe side effects such as impairment in thinking, dizziness, drowsiness, and difficulty concentrating.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Dexmedetomidine or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
General warnings

Liver impairment

This medicine should be used with extreme caution in patients with liver function impairment or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hypotension and bradycardia

This medicine should be used with caution due to the increased risk of hypotension (low blood pressure) and bradycardia (slow heart rate). Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Drowsiness

This medicine may cause drowsiness, dizziness, and difficulty concentrating. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery after treatment with this medicine.

Kidney impairment

This medicine should be used with extreme caution in patients with kidney function impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in children

The safety and efficacy of this medicine have not been clinically established in children below 18 years of age. However, your doctor may prescribe this medicine to children below 18 years of age when the potential benefits outweigh the risks. The risks and benefits should be discussed with the doctor before administering this medicine to children.

Tolerance and tachyphylaxis

Use of this medicine beyond 24 hours may increase the risk of tolerance and tachyphylaxis (a weakened response to the medicine) in some patients.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Alcohol should not be consumed prior to or after receiving this medicine since it may increase the risk of severe side effects such as impairment in thinking, dizziness, drowsiness, and difficulty concentrating.
Interaction with Medicine

Buprenorphine

Propoxyphene

Tizanidine

Amlodipine

Disease interactions

Glaucoma

This medicine should be used with caution in patients with glaucoma due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patients with liver function impairment or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Cardiovascular disorders

This medicine should be used with extreme caution in patients with cardiovascular disorders due to the increased risk of severe hypotension and/or cardiovascular depression. Close monitoring of heart function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Depression

This medicine should be used with caution in patients with glaucoma due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known allergy to this medicine. Report to the doctor all your current medicines including herbs and supplements as well as all your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Causes sleepiness

How it works
This medicine works by altering the action of certain natural substances, which in turn induces sedation.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Miscellaneous anxiolytics, sedatives and hypnotics

Schedule

Schedule H

Dexmedetomidine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 24 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00633

[Internet]. Medicines.org.uk. 2018 [cited 24 December 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.4783.pdf

[Internet]. 2018 [cited 24 December 2018]. Available from:

https://medsafe.govt.nz/profs/Datasheet/p/Precedexinf.pdf

DailyMed - Dexmedetomidine HCL- dexmedetomidine hcl injection [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 5 April 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de6f01a2-9f2d-4c68-9c02-06643704acb1

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Information on this page was last updated on 5 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.