Desmopressin

Description

Desmopressin is the synthetic form of the hormone vasopressin (ADH), which helps in the conservation of water in the body. This medicine is used to treat diabetes insipidus, a condition characterized by intense thirst and heavy urination. The oral form of this medicine is also used to treat bedwetting. The injectable and nasal forms of this medicine are also used to maintain hemostasis (stop/reduce bleeding) in patients suffering from conditions such as Von Willebrand disease and hemophilia A.

Side effects

Major & minor side effects for Desmopressin

  • Nasal congestion
  • Headache
  • Nosebleed
  • Sore throat
  • Nausea
  • Abdominal pain and cramps
  • Flushing
  • Injection site pain

Uses of Desmopressin

What is it prescribed for?

  • Diabetes insipidus
  • Hemophilia A
  • Von Willebrand Disease
  • Bedwetting
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 30 minutes of intravenous administration and within 60 minutes of intranasal or oral administration.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 6 to 14 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to desmopressin or any other inactive ingredients present along with it.

Renal impairment

This medicine is not recommended for use in patients suffering from a moderate-to-severe renal impairment (CrCl less than 50 ml/min) due to the increased risk of worsening of the patient's condition.

Hyponatremia

This medicine is not recommended for use in patients suffering from hyponatremia (decreased sodium levels) or patients with a history of hyponatremia due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.
General warnings

Fluid restriction

This medicine may lead to water intoxication and/or very low blood sodium levels which may be fatal in some patients. Hence, fluid restriction is recommended during treatment with this medicine, especially when the medicine is not used to control increased urination. Report any symptoms such as a headache, nausea, vomiting, weight gain, restlessness, fatigue, lethargy, disorientation, depressed reflexes, loss of appetite, irritability, muscle weakness, muscle spasms or cramps, hallucinations, decreased levels of consciousness, confusion, etc. to the doctor immediately. Close monitoring of blood sodium levels, appropriate patient/caregiver counseling, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Type IIB von Willebrand’s disease

This medicine is not recommended for use in patients suffering from type IIB Von Willebrand disease due to the increased risk of worsening of the patient's condition. Appropriate diagnostic tests should be done to determine the type of Von Willebrand disease prior to beginning therapy with this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Habitual polydipsia (increased thirst)

This medicine should be used with caution in patients with habitual or psychogenic polydipsia who may be more likely to drink excessive amounts of water, due to the increased risk of water intoxication and decreased blood sodium levels. Close monitoring of blood sodium levels, appropriate patient/caregiver counseling, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Nasal and oral forms: If a dose is missed, take/administer it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take/administer the next dose. Do not double the dose to make up for the missed one. Injectable forms: Since this medicine is usually administered in the hospital/clinical setting by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Nasal and oral forms: Seek emergency medical treatment or contact the doctor in case of an overdose. Injectable forms: Since this medicine is usually administered in the hospital/clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by your doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

NSAIDs

Tricyclic Antidepressants

SSRIs

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Nasal/Oral forms: Use this medicine exactly as advised by your doctor. Do not use in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor. Injectable forms: This medicine is generally used prior to a surgical procedure to reduce bleeding in patients suffering from hemophilia A and/or von Willebrand disease. Inform the doctor if you have a known history of an allergy to this medicine. Report to the doctor all your current medications including any herbs and supplements as well as your medical history before undergoing treatment with this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine acts on the kidneys and reduces urine production. When used for the treatment of hemophilia A and Von Willebrand disease, this medicine helps in maintaining hemostasis (stopping/reducing bleeding).
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antidiuretics

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2018 [cited 1 August 2018]. Available from:

https://www.medicines.org.uk/emc/product/1285/smpc#STORAGE

[Internet]. Medicines.org.uk. 2018 [cited 1 August 2018]. Available from:

https://www.medicines.org.uk/emc/product/5447/smpc#PRODUCTINFO

[Internet]. Medicines.org.uk. 2018 [cited 1 August 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.8020.pdf

[Internet]. Tga.gov.au. 2018 [cited 1 August 2018]. Available from:

https://www.tga.gov.au/sites/default/files/auspar-desmopressin-181127-pi.pdf

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Information on this page was last updated on 24 Aug 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.