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Deriphyllin Injection
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Deriphyllin Injection

Manufactured byZydus Cadila
ContainsEtofylline (84.7 mg) + Theophylline (25.3 mg)
Description
Deriphyllin Injection is a combination of etophylline and theophylline that acts as a bronchodilator (increases airflow in your lungs). It is used to treat symptoms of asthma and chronic obstructive pulmonary disorder (a lung disorder in which the flow of air in your lungs is obstructed). It works by relaxing the muscles in your airways, thus helping you to breathe more easily. Deriphyllin Injection has some common side effects like headache, nausea, vomiting, restlessness, stomach pain, etc. These symptoms will go away with time, but if they become severe or persist for a long time, consult your doctor immediately. Deriphyllin Injection is given by a qualified medical practitioner, therefore do not self administer. Your doctor will determine the appropriate dose and duration of the therapy based on your clinical condition. Abrupt discontinuation of this medicine may worsen your condition. Before receiving Deriphyllin Injection, inform your doctor if you have any heart, liver, or kidney troubles. Also, inform your doctor if you are pregnant, planning a pregnancy or are breastfeeding.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Deriphyllin Injection

  • Irregular heart rate
  • Convulsions
  • Stomach discomfort and pain
  • Diarrhoea
  • Headache
  • Sleeplessness
  • Increased urination frequency
  • Twitching and unusual movement of muscles
  • Anxiety
  • Mental Confusion
  • Irritability
  • Allergic Skin Reaction
  • Swelling of ankles or feet
  • Yellowing of skin and eyes
  • Nausea and Vomiting

Uses of Deriphyllin Injection

What is it prescribed for?

  • Asthma
  • Chronic obstructive pulmonary disease (COPD)
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Deriphyllin Injection starts to show its effects in 15 to 20 minutes of its administration.
  • How long do the effects of this medicine last?
    Deriphyllin Injection remains active in your body for around 12- 14 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Avoid consumption of alcohol while receiving Deriphyllin Injection as alcohol reacts with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Deriphyllin Injection.
  • Can this medicine be taken during pregnancy?
    Deriphyllin Injection should be avoided in pregnancy as its effect on pregnant women is unknown.
  • Can this medicine be taken while breast-feeding?
    Deriphyllin Injection is safe to be used during breastfeeding. Human research studies state that this medicine does not enter into the breastmilk in significant amounts and therefore will not cause any harm to your baby.

Allergy

Do not take Deriphyllin Injection if you are allergic to it. Inform your doctor, if you notice any symptoms of allergic reactions such as a skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness or breathing difficulty, etc.

Infants less than 6 months of age

Deriphyllin Injection should not be used in infants below 6 months of age as it can lead to heart problems like tachycardia (increased heart rate).
Warnings for special population

Pregnancy

Deriphyllin Injection should be avoided in pregnancy as its effect on pregnant women is unknown.

Breast-feeding

Deriphyllin Injection is safe to be used during breastfeeding. Human research studies state that this medicine does not enter into the breastmilk in significant amounts and therefore will not cause any harm to your baby.
General warnings

Other diseases

Deriphyllin Injection should be used with caution in certain cases. If you have any problems with your heart, blood vessels, brain, thyroid glands etc. inform your doctor beforehand. If your condition worsens after receiving the injection, inform your doctor immediately.

Theophylline toxicity

Deriphyllin Injection contains theophylline as one of its major ingredients. High doses of this medicine can be dangerous, especially when used for a long time. You will be advised by your doctor to periodically undergo tests to assess the effects of this medicine on your body.

Use in elderly

Deriphyllin Injection should be used with extreme caution in people aged 65 years and above due to the higher risk of side effects.

Driving or operating machinery

Deriphyllin Injection may cause blurred vision or dizziness. If you experience any of these symptoms while taking this medication, it is recommended that you avoid doing any activities such as driving or operating a machinery.

Liver diseases

The effect of Deriphyllin Injection may be delayed if you have liver troubles. Inform your doctor in such cases so that he may prescribe the accurate dose.

Hypertension

Hypertension is an increase in blood pressure. Deriphyllin Injection should be used with caution if you have hypertension as it may further increase your blood pressure leading to a heart attack.

Missed Dose

Deriphyllin Injection is administered in the hospital setting by a qualified healthcare professional, thus the chances of missing a dose are very less. If you miss an appointment for a dose of this medicine, contact your doctor immediately and schedule the dose as soon as possible.

Overdose

Since Deriphyllin Injection is administered in a hospital setting by a qualified healthcare professional, the possibility of an overdose is quite low. If an overdose is suspected, the doctor will initiate emergency medical treatment.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid consumption of alcohol while receiving Deriphyllin Injection as alcohol reacts with this medicine.
Interaction with Medicine

Carbamazepine

Fluvoxamine

Lithium

Phenytoin

Propranolol

Ethinyl Estradiol

Cimetidine

Ciprofloxacin

Azithromycin

Riociguat

Disease interactions

Peptic ulcer

A peptic ulcer is a condition in which sores develop in your stomach and intestinal lining. These sores occur due to stomach acid produced by bacteria and some medicines like aspirin. Deriphyllin Injection should be used with caution if you have peptic ulcers as it can increase the acid secretion and worsen your condition.

Kidney diseases

Deriphyllin Injection is excreted through urine and impaired kidney function can lead to its accumulation in your kidney. This medicine should be used with caution as it can increase the risk of kidney damage in such conditions.

Seizure disorders

A seizure (fits) is an electrical disturbance in the brain that occurs spontaneously. It can alter your behaviour, actions, or emotions, as well as your level of consciousness. Deriphyllin Injection may aggravate seizures (fits) and other central nervous system disorders. This medicine should be used with caution if you have any history of such conditions.

Heart rhythm disorder

Heart rhythm disorder is a condition in which you have improper heartbeats. Deriphyllin Injection should be used with caution as it has been associated with an increased heart rate, which can lead to supraventricular tachycardia (rapid heartbeats) or ventricular arrhythmia (abnormal heartbeats).

Liver diseases

The effect of Deriphyllin Injection may be delayed if you suffer from any liver problems. Inform your doctor so that he may prescribe the accurate dose.
Food interactions
Avoid or limit the intake of caffeine while on treatment with Deriphyllin Injection as caffeine can alter the level of this medicine in your blood. It can also increase the side effects such as headache, sleeplessness, and an increase in blood pressure and heart rate.
Avoid the consumption of tobacco and marijuana while receiving Deriphyllin Injection. Cigarette smoking can decrease the effectiveness of this medicine. It can also increase the side effects of this medicine such as headache, sleeplessness, and an increase in blood pressure and heart rate. The risk of side effects is high even with secondhand smoking (a combination of smoke from the burning end of a cigarette and smoke exhaled by smokers).
Lab interactions

Serum uric acid test

A serum uric acid test is used to determine the level of uric acid in your blood. Use of Deriphyllin Injection may give a false-positive result for this test. It is advised that you inform your doctor and lab technician about the usage of this medicine before the test is performed.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Deriphyllin Injection should be administered by a qualified healthcare professional only. Inform your doctor if you have a known allergy to this medicine. Before getting this medicine, inform your doctor about all of your current medications as well as your medical problems. Deriphyllin Injection does not act immediately and should not be used to treat acute breathing problems.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Deriphyllin Injection works by relaxing the airway muscles and widens the airways of your lungs. It also reduces the sensitivity of the lungs to allergens that irritate and narrow your airways.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Methylxanthines, Antiasthmatic combinations

Schedule

Schedule H

Pubchem.ncbi.nlm.nih.gov. 2021. Theophylline. [online] Available at: < [Accessed 12 July 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/2153>

Pubchem.ncbi.nlm.nih.gov. 2021. Etofylline. [online] Available at: < [Accessed 12 July 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/1892>

Drugs, H., 2021. Theophylline: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 12 July 2021].

https://medlineplus.gov/druginfo/meds/a681006.html>

Asthma UK. (2019). Theophylline | Asthma UK. [online] Available at: ‌

https://www.asthma.org.uk/advice/inhalers-medicines-treatments/add-on-treatments/theophylline/.
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Information on this page was last updated on 27 Aug 2021

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