Decitabine

Description

Decitabine is used for the treatment of myelodysplastic syndrome (MDS). It is a group of conditions where the bone marrow is not able to produce enough healthy blood cells. This medicine may also be used for the treatment of adult patients (age >= 65) with newly diagnosed or secondary acute myeloid leukemia (AML).

Side effects

Major & minor side effects for Decitabine

  • Excessive tiredness and weakness
  • Pale and clammy skin
  • Headache and dizziness
  • Mental confusion
  • Fast/irregular heart beat
  • Difficulty in falling or staying asleep
  • Shortness of breath
  • Nausea or vomiting
  • Diarrhea
  • Constipation
  • Stomach pain
  • Heartburn and indigestion
  • Painful sores in mouth, or on tongue or lips
  • Pinpoint red spots on skin
  • Change in skin color
  • Hair loss
  • Joint or muscle pain
  • Chest discomfort
  • Swelling of the hands, ankles, feet, or lower legs
  • Pain,swelling, and itching at the injection site
  • Unusual bleeding or bruising
  • Skin rash, hives, or itching
  • Difficulty in swallowing
  • Sore throat and fever
  • Increased thirst
  • Increased urination frequency
  • Blurred vision
  • Excessive hunger

Uses of Decitabine

What is it prescribed for?

  • Myelodysplastic syndrome
  • Acute Myeloid Leukemia
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time taken by this medicine to show its effects is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to decitabine or any other inactive ingredients present in the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you report all your current medicines, including any herbs and supplements, to the doctor before beginning treatment with this medicine.

Immunization or vaccination

Report the administration of any vaccine in the recent times to the doctor before receiving therapy with this medicine. Your doctor may postpone treatment with Decitabine based on your clinical condition.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Kidney diseases

This medicine should be used with caution in patients with an impairment of the normal renal function due to the increased risk of adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases.

Liver diseases

This medicine should be used with caution in patients with an impairment of the normal liver function due to the increased risk of adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases.

Active infection

This medicine should not be administered if the patient has an active or uncontrolled infection. Appropriate corrective measures should be taken and the therapy should be delayed until the infection is resolved or controlled.

Abnormal blood count

This medicine should be used with extreme caution in patients with low white blood cell counts due to the increased risk of worsening of the patient's condition, including the development of life-threatening infections. Close monitoring of complete blood counts is recommended during treatment with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's clinical condition.

Prevention of pregnancy

It is advised to prevent pregnancies during therapy with this medicine. Your doctor may advise effective means of contraception to avoid a pregnancy during treatment with this medicine.

Missed Dose

Since this medicine is usually administered in a hospital by a qualified healthcare professional, the likelihood of a missed dose is very low. However, if you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions.

Overdose

Since this medicine is usually administered in a hospital by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be instituted by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Imatinib Mesylate

Vitamin E

Leflunomide

Live attenuated vaccines and related products

Infliximab

Adalimumab

Clozapine

Bendamustine

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered in a hospital by a trained healthcare professional. This medicine is given for at least 4 cycles and may be continued further based on the therapeutic response and clinical condition. Do not miss a scheduled administration of this medicine. This medicine has very specific handling requirements and hence self-administration or unsupervised administration at home should be avoided. Report all your current medicines, including any herbs and supplements, as well as your medical conditions to the doctor before receiving this medicine. Report any unusual symptoms or severe undesired side effects to the doctor immediately.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine helps the bone marrow to produce normal blood cells. It also kills the abnormal cells in the bone marrow.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Antimetabolites

Schedule

Schedule H

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https://astx.com/wp-content/uploads/2016/11/SUPG_News_2011_6_6_General_Releases2.pdf

[Internet]. Medicines.org.uk. 2018 [cited 20 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.2838.pdf

[Internet]. Otsuka-us.com. 2018 [cited 20 September 2018]. Available from:

https://www.otsuka-us.com/media/static/DACOGEN-PI.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 20 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021790lbl.pdf

DailyMed - Decitabine injection [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 20 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bc5e093a-e841-42f0-b42a-cb6ba73a8679

Decitabine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 20 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB01262

Home | Dacogen (decitabine) [Internet]. Dacogen.com. 2018 [cited 20 September 2018]. Available from:

https://www.dacogen.com/

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Information on this page was last updated on 20 Sep 2018

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.