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Decarb-500 Injection

Manufactured byCIPLA LTD
ContainsDacarbazine
Description

Decarb-500 Injection is an anticancer agent which is used in the treatment of malignant melanoma, a type of skin cancer and Hodgkin's Disease, a type of cancer that originates from the blood cells (lymphocytes) and affects the lymphatic system. It is also used to treat soft tissue sarcomas (cancers that start in tissues like bone or muscle) in adult patients.

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Side effects

Major & minor side effects for Decarb-500 Injection

  • Redness, pain or swelling at the injection site
  • Blood in urine or stools
  • Fever or chills
  • Shortness of breath
  • Stomach pain
  • Yellow eyes or skin
  • Black or tarry stools
  • Loss of appetite
  • Nausea and vomiting

Uses of Decarb-500 Injection

What is it prescribed for?

  • Malignant Melanoma
  • Hodgkin’s disease
  • Soft tissue sarcomas
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Dacarbazine or any other inactive ingredients present along with this medicine.

Blood disorders

This medicine is not recommended for use in patients with blood disorders such as leukopenia, thrombocytopenia, or severe anemia.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Kidney impairment

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause dizziness, drowsiness, weakness or tiredness. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you experience any of these symptoms.

Risk of infections

Use of this medicine may weaken the immune system and may make you more vulnerable to infections. It is advised that you avoid coming in contact with people suffering from an infection while taking this medicine.

Oral intake restriction

Restriction of oral intake for about 4 to 6 hours is advised prior to the treatment with this medicine to avoid gastrointestinal disturbances such as nausea, vomiting, etc.

Missed Dose

It is advised that you do not miss any dose. If you miss any dose, you should contact your doctor immediately.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

BCG vaccine

Etanercept

Infliximab

Clozapine

Disease interactions

Infections

This medicine should be used with extreme caution in patients suffering from infections due to the increased risk of bone marrow suppression which may further worsen the patient's existing condition. Report any signs or symptoms suggesting infection such as fever, sore throat, weight loss, red or inflamed skin, pain or burning during urination, etc. to the doctor immediately. Close monitoring of hematopoietic function is recommended. An alternative treatment option should be considered in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine blocks the cancer cells from multiplying and stops their growth.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Alkylating agents, Antineoplastics

Schedule

Schedule H

Dacarbazine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 6 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00851

DailyMed - Dacarbazine - dacarbazine injection, powder, for solution [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 6 December 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b6b97e41-5f15-498c-abfb-d8443ea4d216

Dacarbazine 100 mg powder for solution for injection/infusion - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 6 December 2018]. Available from:

https://www.medicines.org.uk/emc/product/999/smpc

[Internet]. Edkb.fda.gov. 2018 [cited 6 December 2018]. Available from:

https://edkb.fda.gov/webstart/arraytrack/PDFfile/LTKB_BD/dacarbazine.pdf

Dacarbazine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 22 February 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a682750.html

Decarb Injection [Internet]. CiplaMed. 2019 [cited 22 February 2019]. Available from:

https://ciplamed.com/content/decarb-injection
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Information on this page was last updated on 22 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.