Daratumumab

Description

Daratumumab is an anticancer medicine which can be used alone or in combination with other medications to treat a type of blood cancer known as multiple myeloma in patients who have not adequately responded to other anticancer medications.

Side effects

Major & minor side effects for Daratumumab

  • Blurred or double vision
  • Chills
  • Dizziness
  • Fever
  • Headache
  • Nervousness
  • Skin rash and hives
  • Sweating
  • Confusion
  • Nausea
  • Unsual tiredness or weakness
  • Bleeding gums
  • Cough

Uses of Daratumumab

What is it prescribed for?

  • Multiple Myeloma
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to daratumumab or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
General warnings

Neutropenia

This medicine may cause neutropenia (decrease in white blood cells) in some patients and may increase the risk of serious infections. Report any unusual symptoms such as a fever, chills, sore throat, etc. to the doctor immediately. Close monitoring of blood cell counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Thrombocytopenia

This medicine may cause thrombocytopenia (decrease in platelet count) in some patients. Close monitoring of platelet counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Driving or operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Liver impairment

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Kidney impairment

This medicine should be used with extreme caution in patients suffering from kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. If you miss any scheduled session, contact your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Etanercept

Infliximab

Adalimumab

Clozapine

Certolizumab

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by stopping the growth of cancer cells by interrupting the function of a certain protein in the body.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

CD38 monoclonal antibodies

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2019 [cited 27 March 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/761036s004lbl.pdf

DailyMed - Darzalex - daratumumab injection, solution, concentrate [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 29 May 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4d0efe9-5e54-467e-9eb4-56fa7d53b60b

Daratumumab - DrugBank [Internet]. Drugbank.ca. 2019 [cited 27 March 2019]. Available from:

https://www.drugbank.ca/drugs/DB09331

Daratumumab Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 27 March 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a616002.html

[Internet]. Medicines.org.uk. 2019 [cited 27 March 2019]. Available from:

https://www.medicines.org.uk/emc/files/pil.7250.pdf

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Information on this page was last updated on 29 May 2019

Disclaimer

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