Daptomycin

Description

Daptomycin is an antibiotic that is used alone or in combination with other medicines to treat severe bacterial infections of the blood, heart, and skin. This medicine is not recommended for use in case of a common cold, flu, or other viral infections since it is active against infections caused by bacteria only.

Side effects

Major & minor side effects for Daptomycin

  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Fever
  • Irregular heartbeat
  • Unusual weight gain or loss
  • Tingling of hands or feet
  • Excessive air or gas in stomach
  • Black or tarry stools
  • Dizziness and fainting
  • Dry mouth

Uses of Daptomycin

What is it prescribed for?

  • Skin and Skin Structure Infection
  • Bacteremia
  • Endocarditis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use if you have a known allergy to Daptomycin or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Kidney diseases

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Drug-resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing benefits and may even cause toxicity. It may also increase the risk of development of bacteria that are drug-resistant.

Anaphylaxis

Use of this medicine may cause anaphylactic reactions such as shock, skin rashes, nausea, vomiting, diarrhea, abdominal cramps, increased heart rate, low blood pressure, itching, fever, chills, bronchospasm, and angioedema in some patients. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Clostridium difficile-associated diarrhea

Antibiotic therapy will cause an imbalance in the normal microbial flora of the large intestine, which may promote the growth of a bacteria called Clostridium difficile and you may experience severe diarrhea as a result. Report any such incidence to the doctor on priority and avoid usage of this medicine in such cases.

Use in children

This medicine is not recommended for use in patients less than 12 months of age since the safety and efficacy of use are not clinically established.

Muscle degradation and Rhabdomyolysis

This medicine may cause muscle breakdown and rhabdomyolysis in some patients, a condition which can be fatal. This may cause symptoms such as muscle pain, severe tiredness, and weakness. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Cholera Vaccine

Ethinyl Estradiol

Atorvastatin

Diclofenac

Disease interactions

Kidney Disease

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by interfering with certain processes that result in the eventual death of the bacteria.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Miscellaneous antibiotics

Schedule

Schedule H

Daptomycin Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 21 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a608045.html

Daptomycin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 21 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00080

[Internet]. Accessdata.fda.gov. 2018 [cited 21 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021572s038lbl.pdf

Daptomycin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 21 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/daptomycin

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Information on this page was last updated on 22 Aug 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.