Dapagliflozin

Description

Dapagliflozin is an antidiabetic medicine used alone or in a combination with other medicines to treat type 2 diabetes in adult patients. Patients are advised to follow a strict diet and exercise regimen along with this medicine for the best possible effect. This medicine is not recommended for use in patients suffering from type 1 diabetes or diabetic ketoacidosis.

Side effects

Major & minor side effects for Dapagliflozin

  • Increased hunger
  • Increased thirst
  • Blurred vision
  • Bloody or cloudy urine
  • Cold sweats
  • Difficult or painful urination
  • Headache
  • Nausea and vomiting
  • Unusual tiredness or weakness

Uses of Dapagliflozin

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Avoid or limit the uptake of alcohol while receiving this medicine due to the increased risk of altered blood glucose levels. Special precaution is advised if your diabetes is not well controlled or if you are suffering from high triglycerides levels, neuropathy (nerve damage), or pancreatitis.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with known allergy to dapagliflozin or any other inactive ingredients present along with it.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal function impairment due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Kidney diseases

This medicine should be used with caution in patients with kidney disease due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Use in children

This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.

Ketoacidosis

This medicine should be used with extreme caution since it may increase the risk of ketoacidosis. Report any symptoms such as difficulty breathing, abdominal pain, unusual tiredness, etc. to the doctor immediately. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Hypotension

This medicine should be used with caution in patients with hypotension due to the increased risk of adverse effects. Correct the volume status before initiating treatment with this medicine. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Liver diseases

This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hypoglycemia

This medicine may cause hypoglycemia on concomitant use with insulin and insulin secretagogues in some patients. This risk is especially higher in patients suffering from kidney diseases, malnourishment, pituitary gland diseases, etc. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments may be required based on the clinical condition. Your doctor may advise you to carry sugar candy to counteract the effects of low blood sugar levels (hypoglycemia).

Urosepsis

This medicine should be used with caution in patients with urinary tract infections due to the risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Genital mycotic infections

This medicine should be used with caution in patients with genital mycotic infections due to the risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid or limit the uptake of alcohol while receiving this medicine due to the increased risk of altered blood glucose levels. Special precaution is advised if your diabetes is not well controlled or if you are suffering from high triglycerides levels, neuropathy (nerve damage), or pancreatitis.
Interaction with Medicine

Dexamethasone

Acetazolamide

Candesartan

Benazepril

Amlodipine

Carvedilol

Gatifloxacin

Disease interactions

Renal Dysfunction

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with severe renal function impairment.

Bladder cancer

This medicine is not recommended for use in patients with bladder cancer due to the increased risk of worsening of the patient's condition. All the risks and benefits should be discussed with the doctor before taking this medicine. An alternative treatment option should be considered based on the clinical condition of the patient.

Hyperlipidemia

This medicine should be used with caution in patients with hyperlipidemia since it may increase the blood levels of LDL cholesterol. Regular monitoring of the lipid levels is required while using this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hypotension

This medicine should be used with caution in patients with hypotension due to the increased risk of adverse effects. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Your dose is likely to change over time based on therapeutic response and clinical condition. Regular monitoring of blood sugar levels is recommended during treatment with this medicine. You should always carry a sugar candy with you to counteract the unexpected lowering of blood sugar levels. Do not change the dose or duration of use without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It reduces glucose reabsorption from the kidneys and lowers the blood glucose levels.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

SGLT-2 inhibitors

Schedule

Schedule H

Dapagliflozin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 6 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB06292

[Internet]. Accessdata.fda.gov. 2018 [cited 6 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/202293s003lbl.pdf

Dapagliflozin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 6 September 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a614015.html

Forxiga 10 mg film coated tablets - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 6 September 2018]. Available from:

https://www.medicines.org.uk/emc/product/7607/smpc#

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Information on this page was last updated on 11 Mar 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.