Dandel 2% Lotion

Manufactured bySol Derma Pharmaceuticals Pvt. Ltd.
ContainsKetoconazole
Description

Dandel 2% Lotion is an anti-fungal which is used to treat a variety of infections caused by fungi. It is recommended when no other safer alternatives are available due to the risk of the liver injury. Do not take this medicine if you have a known allergy to it.

Side effects

Major & minor side effects for Dandel 2% Lotion

  • Blurred vision
  • Chest pain
  • Dizziness
  • Fast heartbeat
  • Headache
  • Increased sensitivity of the eyes to sunlight
  • Pale skin
  • Yellow colored eyes or skin
  • Joint pain
  • Skin rash
  • Diarrhea
  • Hair loss or thinning of the hair
  • Skin irritation

Uses of Dandel 2% Lotion

What is it prescribed for?

  • Blastomycosis
  • Chromomycosis
  • Coccidioidomycosis
  • Histoplasmosis
  • Paracoccidioidomycosis
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine is observed in 1 to 2 hours.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 8 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended if you are taking this medicine. It may increase the risk of dizziness and fainting. Avoid performing activities that need mental alertness like operating machinery or driving a vehicle.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use during breastfeeding women unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine. Do not breastfeed for at least 5 hours after the dose to reduce the risk of exposure.

Allergy

Dandel 2% Lotion is not recommended for use if you have a known allergy to this medicine.

QT Interval prolonging drugs

Dandel 2% Lotion is not recommended for co-administration with drugs that are known to cause specific changes in heart rhythm.
Warnings for special population

Pregnancy

This medicine is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine.

Breast-feeding

This medicine is not recommended for use during breastfeeding women unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine. Do not breastfeed for at least 5 hours after the dose to reduce the risk of exposure.
General warnings

Liver injury

Dandel 2% Lotion can cause severe liver injury when high doses are used. Any known incidence of liver disease should be reported to the doctor. Dosage adjustments and safety monitoring might be required in such cases.

QT prolongation

Dandel 2% Lotion may increase the QT prolongation. This risk is more if coadministered with other medicines that can cause QT prolongation. Close monitoring of heart function is necessary.

Kidney disease

Dandel 2% Lotion may decrease the adrenal corticosteroid secretion when high doses are used. The recommended dose should not exceed 400 mg. Close monitoring of adrenal function is necessary.

Missed Dose

The missed dose can be taken as soon as you remember. If it is time for the next dosage then the missed dose can be skipped.

Overdose

Inform your doctor immediately if you are experiencing symptoms of overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Concurrent use of ketoconazole and ethanol may result in a disulfiram-like reaction (sweating, nausea, flushing, headache).

Instructions

Consumption of alcohol is not recommended if you are taking this medicine. It may increase the risk of dizziness and fainting. Avoid performing activities that need mental alertness like operating machinery or driving a vehicle.
Interaction with Medicine

Alprazolam

Cisapride

Clopidogrel

Erythromycin

Warfarin

Atorvastatin

Disease interactions

Liver Disease

Dandel 2% Lotion should be administered with caution if you are suffering from impaired liver functioning. Suitable dosage adjustments and safety monitoring become necessary in such cases.

QT Prolongation

Dandel 2% Lotion should be very carefully administered if you have any pre-existing heart conditions. Suitable dosage adjustments and safety monitoring is recommended in such cases.

Kidney disease

Suitable adjustment is dosage is required based on the extent of kidney impairment. An adjustment in dosage is recommended. If the patient is on hemodialysis then the blood level of Dandel 2% Lotion should be monitored after each session and then the adjusted dose should be administered.
Food interactions
Information not available.
Lab interactions
Information not available.
Dandel 2% Lotion should be taken following all the instructions that are given by your doctor. To ensure complete recovery and no relapse, the full course of treatment should be followed. It is more effective if taken at the same time on all days. Any instance of side effect should be reported to the doctor immediately.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Dandel 2% Lotion acts by stopping the production of a certain vital component for the fungi. This results in disruption of cell membrane formation process and inhibits the growth of the organism.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Azole antifungals

Schedule

Schedule H

[Internet]. 2017 [cited 23 March 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/30077

DailyMed - Ketoconazole cream [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 23 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cad7c647-34a9-4e4e-83b3-8d78e58f588f

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 23 March 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 23 March 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2
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