Danazol

Description

Danazol is used to treat endometriosis, fibrocystic breast disease, and heriditery angioedema. It is not recommended for use in the elderly population and children.

Side effects

Major & minor side effects for Danazol

  • Hypersensitivity
  • Acne
  • Weight gain
  • Changes in menstrual cycle
  • Decrease in breast size
  • Vaginal dryness and irritation
  • Sweating and flushing
  • Oily skin or hair
  • Hirsutism
  • Peeling and blistering of skin
  • Deepening of the voice

Uses of Danazol

What is it prescribed for?

  • Endometriosis
  • Fibrocystic breast disease
  • Hereditary angioedema
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with Danazol due to the increased risk of severe side effects such as shortness of breath, vomiting, restlessness, etc.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women.

Allergy

This medicine is not recommended for use in patients with a known allergy to danazol or any other components present along with it.

Androgen dependent tumor

This medicine is not recommended for use in patients with an androgen-dependent tumor due to the increased risk of worsening of the patient's condition.

Undiagnosed vaginal bleeding

This medicine is not recommended for use in patients with an undiagnosed vaginal bleeding due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women.

Breast-feeding

This medicine is not recommended for use in breastfeeding women.
General warnings

Use in pediatrics

This medicine is not recommended for use in children and adolescents.

Geriatric use

This medicine is not recommended for use in elderly patients.

Liver function

Danazol may cause elevations in the levels of liver enzymes. It is not recommended for use in patients with severe liver dysfunction. Caution is advised while using this medicine in patients with mild to moderate liver impairment. Appropriate dose adjustments may be required based on the clinical condition.

Blood sugar levels

Danazol may cause changes in blood sugar levels. This risk is especially higher in patients with diabetes mellitus. Regular monitoring of blood sugar levels is recommended while using this medicine. Appropriate dose adjustments may be required based on the clinical condition.

Porphyria

This medicine is not recommended for use in patients with porphyria due to the increased risk of worsening of the patient's condition.

Migraine

Danazol is not recommended for use in patients with migraines since it may cause a migraine-like headache and may interfere with the anti-migraine treatment.

Sports

Use of this medicine is prohibited under the World Anti-Dopping Agency S1 classification in all sports events.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Danazol due to the increased risk of severe side effects such as shortness of breath, vomiting, restlessness, etc.
Interaction with Medicine

Pimozide

Warfarin

Leflunomide

Atorvastatin

Naloxegol

Dicumarol

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions

CPK

Danazol may interfere with the laboratory tests for CPK and this may result in inaccurate test results. It is advised that you inform the doctor about treatment with Danazol before undergoing any laboratory test.

Glucose

Danazol may interfere with the laboratory tests for glucose and this may result in inaccurate test results. It is advised that you inform the doctor about treatment with Danazol before undergoing any laboratory test.

Lipids

Danazol may interfere with the laboratory tests for lipids and this may result in inaccurate test results. It is advised that you inform the doctor about treatment with Danazol before undergoing any laboratory test.

Testosterone

Danazol may interfere with the laboratory tests for testosterone and this may result in inaccurate test results. It is advised that you inform the doctor about treatment with Danazol before undergoing any laboratory test.

Thyroid function tests

Danazol may interfere with thyroid function tests and this may result in inaccurate test results. It is advised that you inform the doctor about treatment with Danazol before undergoing any laboratory test.
Take Danazol as instructed by the doctor. Do not take in larger or smaller amounts than advised/prescribed or share this medicine with other people. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Danazol acts on the ovaries and the pituitary gland to reduce the abnormal growth and spread of cells in the conditions of endometriosis and fibrocystic breast disease. For the condition of hereditary angioedema, Danazol increases certain natural substances in the body. This helps in reducing the episodes of abnormal swelling of the face, hands, and feet.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antigonadotropic agents

Schedule

Schedule H

DailyMed - DANAZOL- danazol capsule [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 23 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f2c9b713-aafc-49ca-866e-334d9b5c2e2d&audience=consumer

Danazol: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 23 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682599.html

[Internet]. 2017 [cited 23 August 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.32532.latest.pdf

Danazol - DrugBank [Internet]. Drugbank.ca. 2017 [cited 23 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB01406

[Internet]. 2017 [cited 23 August 2017]. Available from:

http://products.sanofi.ca/en/cyclomen.pdf

Danazol [Internet]. Snomedbrowser.com. 2017 [cited 23 August 2017]. Available from:

http://www.snomedbrowser.com/Codes/Details/126124009

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Information on this page was last updated on 13 Sep 2017

Disclaimer

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