Dalteparin

Description

Dalteparin is an anticoagulant used to prevent the formation and growth of blood clots in patients with certain specific medical conditions. It is also used to prevent blood clots that may potentially form during certain medical procedures. It is used in combination with aspirin to prevent serious complications associated with angina and heart attacks.

Side effects

Major & minor side effects for Dalteparin

  • Injection site redness, bruising, or sores
  • Unusual bleeding or bruising
  • Dark red spots in the mouth
  • Bloody or coffee colored vomit
  • Black or tarry stools
  • Excessive menstrual bleeding
  • Dizziness and lightheadedness
  • Swelling of eyelids, face, lips, tongue
  • Difficulty in swallowing
  • Difficulty in breathing
  • Back pain
  • Muscle weakness
  • Fever
  • Burning or tingling sensation of skin

Uses of Dalteparin

What is it prescribed for?

  • Prophylaxis of ischemic complications in unstable angina
  • Prophylaxis for Deep Vein Thrombosis
  • Deep Vein Thrombosis Prophylaxis after surgery
  • Venous thromboembolic events
  • Prophylaxis of ischemic complications in myocardial infarction
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1-2 hours of administration.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 12 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is recommended for use in pregnant women only when absolutely necessary and the potential benefits outweigh the risks involved.
  • Usage while breast-feeding?
    This medicine is recommended for use in breastfeeding women only when absolutely necessary and the potential benefits outweigh the risks involved.

Allergy

This medicine is not recommended for use in patients with a known allergy to dalteparin or any other inactive ingredient present along with it. Use of this medicine is also not recommended in patients having a known allergy to heparin or pork products.

Active major bleeding

This medicine is not recommended for use in patients with a known heavy active bleeding due to the increased risk of worsening of the patient's condition.

Thrombocytopenia

This medicine is not recommended for use in patients with an abnormally low platelet count due to the increased risk of excessive bleeding.

Regional anesthesia

This medicine is not recommended for use in patients with unstable angina, non-Q-wave myocardial infarction, or cancer who are undergoing regional anesthesia due to the increased risk of excessive bleeding.

Epidural/spinal anesthesia

This medicine is not recommended for use for the prevention of venous thromboembolic events in patients receiving epidural/spinal anesthesia.
Warnings for special population

Pregnancy

This medicine is recommended for use in pregnant women only when absolutely necessary and the potential benefits outweigh the risks involved.

Breast-feeding

This medicine is recommended for use in breastfeeding women only when absolutely necessary and the potential benefits outweigh the risks involved.
General warnings

Hemorrhage and risk factors

Use of this medicine should be initiated only after internal bleeding or hemorrhage and associated risk factors are ruled out. All the underlying causes of bleeding such as peptic ulcer disease, hemophilia, impaired hemostasis, etc. should also be ruled out before the administration of this medicine.

Thrombocytopenia

Use of this medicine may cause low levels of platelets (thrombocytopenia). It is advised to monitor the blood platelet levels at regular intervals while this medicine is administered. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Benzyl alcohol as preservative

Dosage forms containing benzyl alcohol as a preservative should not be administered to neonates, infants, pregnant or breastfeeding women. Benzyl alcohol may cause a fatal adverse event known as Gasping syndrome in neonates and infants.

Liver/kidney disease

This medicine should be used with caution in patients having an impairment of normal liver/kidney function. Appropriate dose adjustments and frequent clinical monitoring are recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition.

Other medicines

This medicine may interact with many other medicines and may cause severe side effects. Hence, you are advised to report the use of all medicines including herbs and supplements to the doctor before beginning treatment with this medicine.

Epidural/spinal/regional anesthesia

This medicine should not be used in patients receiving regional, epidural, or spinal anesthesia due to the increased risk of excessive bleeding and formation of hematoma.

Route of administration

This medicine should be administered subcutaneously. The intramuscular route of administration should be avoided.

Interchangeability with other heparins

This medicine should not be used interchangeably with other low molecular weight heparins.

Missed Dose

This medicine is usually administered in a clinical or hospital setup. However, if you are administering it at home and miss a scheduled dose, then call your doctor immediately for further instructions.

Overdose

Seek emergency medical attention in case of an overdose or suspected overdose. Symptoms may include nosebleed, unusual bruising and bleeding, and the presence of blood in stool or urine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clopidogrel

Escitalopram

Fluoxetine

Mifepristone

Warfarin

Aspirin

Heparin

Diclofenac

Alteplase

Streptokinase

Ubiquinone/Vitamin E

Ginseng

Dextran

Choline salicylate

Disease interactions

Hemophilia

This medicine should be administered with extreme caution in patients suffering from hemophilia or other bleeding disorders due to the increased risk of excessive bleeding.

Liver Disease

This medicine should be administered with extreme caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function may be necessary based on the clinical condition.

Peptic ulcer disease

This medicine should be administered with extreme caution in patients with peptic ulcer disease due to the increased risk of excessive bleeding.

Retinopathy

This medicine should be administered with extreme caution in patients with retinopathy associated with high blood pressure and diabetes due to the increased risk of worsening of the patient's condition.

Bacterial endocarditis

This medicine should be used with extreme caution in patients with subacute bacterial endocarditis, characterized by swelling of the heart walls or valves due to a bacterial infection, due to the risk of worsening of the patient's condition.

Kidney Disease

This medicine should be administered with extreme caution in patients suffering from kidney diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments should be done based on the clinical condition.
Food interactions
This medicine should be used with caution with fish oil or other food products containing omega-3 polyunsaturated fatty acids due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.
This medicine should be used with caution with ginger/garlic due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and the presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.
Lab interactions
Information not available.
Administer Dalteparin exactly as instructed by the doctor. It should not be injected into the muscles. It is advised to administer this medicine under the supervision of a doctor in a clinical setup with regular monitoring of blood clotting time and other related parameters. Your doctor may ask you to undergo certain tests to determine the safety of use of this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by interfering with the normal clotting process and decreasing the clot forming ability of the blood.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Heparins

Schedule

Schedule H

DailyMed - FRAGMIN- dalteparin sodium injection, solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 28 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=529711c6-6029-4e50-8ece-c0e59b06ff38

Dalteparin Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 28 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a696006.html

[Internet]. 2017 [cited 28 August 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.14279.latest.pdf

Dalteparin - DrugBank [Internet]. Drugbank.ca. 2017 [cited 28 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB06779

Dalteparin sodium [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 28 August 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/59350241

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Information on this page was last updated on 4 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.