Daclatasvir
Description
Daclatasvir is an antiviral medicine composed of Daclatasvir. It is used in the treatment of chronic hepatitis C infection. It is an infection caused by a virus that attacks your liver and leads to pain and swelling.
Daclatasvir works by stopping the growth of viruses in your body, thus reducing the infection. This medicine is not recommended for use if you have a known history of hepatitis B infection (serious liver infection caused by the hepatitis B virus).
Daclatasvir may cause side effects like chills, headache, irritability, diarrhoea, etc. Most of them are temporary and resolved on their own. Consult your doctor if these side effects are persistent or bothering you. Do not take this medicine if you are allergic to it.
Daclatasvir can be taken with or without food, as prescribed by your doctor. Your dose will be dependent on the severity of your condition. Try to take this medicine same time every day to maintain a constant level of medicine in your body. Do not stop taking this medicine without consulting with your doctor as your symptoms could come back.
Daclatasvir is not recommended to be used in children below 18 years of age. Inform your doctor about all your current medications and medical conditions. This can help your doctor to adjust your dose to avoid any side effects. If you are pregnant or breastfeeding, consult your doctor before taking this medicine.
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Side effects
Major & minor side effects for Daclatasvir
- Headache
- Unusual tiredness
- Nausea and vomiting
- Diarrhoea
- Severe skin rash and hives
- Dizziness
- Sleep disturbances
- Shortness of breath
- Chest pain or discomfort
- Mental confusion
- Memory problems
Uses of Daclatasvir
What is it prescribed for?
- Chronic Hepatitis C
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Concerns
Commonly asked questions
- Onset of actionThe time required for Daclatasvir to show its effect is not clinically established.
- Duration of effectDaclatasvir can remain in your body for 3-4 days.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit-forming tendencies were reported for Daclatasvir.
- Usage in pregnancy?There is no clinically established data available on the use of Daclatasvir in pregnant women. Therefore, consult your doctor to discuss all risks and benefits before taking this medicine.
- Usage while breast-feeding?Daclatasvir has not been studied in breastfeeding mothers being treated for Hepatitis C infection. Therefore, consult your doctor before taking this medicine to understand the risks and benefits associated with this medicine.
Allergy
Daclatasvir is not recommended if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Strong CYP3A inducers
Daclatasvir is not recommended for use in people receiving strong CYP3A inducers such as phenytoin, carbamazepine, rifampin, etc. This can complicate your treatment. Hence, combining these medicines with Daclatasvir is not recommended.
Warnings for special population
Pregnancy
There is no clinically established data available on the use of Daclatasvir in pregnant women. Therefore, consult your doctor to discuss all risks and benefits before taking this medicine.
Breast-feeding
Daclatasvir has not been studied in breastfeeding mothers being treated for Hepatitis C infection. Therefore, consult your doctor before taking this medicine to understand the risks and benefits associated with this medicine.
General warnings
Other medicines
Daclatasvir may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.
Change in heart rate
Daclatasvir may increase the risk of decreased heart rate. This risk is especially higher in people having heart problems. An alternative treatment option may be necessary in some cases based on the clinical condition.
Tests prior to initiation of therapy
You may require to undergo certain tests like NS5A resistance testing if you have hepatitis C with liver cirrhosis (a condition of the liver in which it becomes fibrous) before initiation of Daclatasvir.
Kidney impairment
Daclatasvir should be used with caution if you have kidney problems as a diseased kidney will not be able to filter the medicine properly. This can increase the risk of toxicity. Your doctor will monitor your kidney functions closely and/or adjust your dose if required.
Liver impairment
Daclatasvir should be used with caution if you have liver problems as a diseased liver will not be able to break down and absorb the medicine properly. This can increase the risk of toxicity. Your doctor will monitor your liver functions closely and/or adjust your dose if required.
Use in children
Daclatasvir is not recommended for use in children less than 18 years of age since the safety and efficacy of use are not clinically established.
Driving or operating machinery
Daclatasvir may cause symptoms such as dizziness, confusion, etc. Hence, do not perform activities such as driving vehicles or operating machines if you experience any of these symptoms during treatment with this medicine.
Missed Dose
Take the missed dose of Daclatasvir as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose of Daclatasvir.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Dexamethasone
Atazanavir
Bosentan
Modafinil
Dabigatran
Efavirenz
Nevirapine
Digoxin
Clarithromycin
Ketoconazole
Atorvastatin
Disease interactions
Hepatitis B
Daclatasvir should be used with caution if you have a known history of hepatitis B due to the increased risk of worsening your condition. Your doctor may replace this medicine with another suitable alternative in such cases. Your doctor may also prescribe tests for Hepatitis B infection before starting the treatment,
Food interactions
Information not available.
Lab interactions
Information not available.
Take Daclatasvir as prescribed by your doctor. Drink plenty of water with it to avoid stomach irritation. Do not break, crush or chew the tablet.
Do not take this medication for a longer duration than suggested by your doctor. Consult your doctor before you stop taking this medication.
Keep Daclatasvir away from children and pets. Do not use this medicine after the expiry date. Throw away the unused medicine safely after the expiry date.
Your doctor may closely monitor your liver functions while you are on this therapy. If you develop any undesired effects, or if your condition is worsening, inform your doctor immediately.
Miscelleneous
How it works
Daclatasvir is an antiviral medication. It works by lowering the load of the hepatitis C virus in the body and removing the virus from the blood over a period of time. This helps in stopping the spread of the infection.
Legal Status
Classification
Category
NS5A inhibitors
Schedule
Schedule H
Packageinserts.bms.com. 2022. [online] Available at: < [Accessed 23 March 2022].
Dailymed.nlm.nih.gov. 2022. These highlights do not include all the information needed to use DAKLINZA safely and effectively. See full prescribing information for DAKLINZA. DAKLINZA® (daclatasvir) tablets, for oral useInitial U.S. Approval: 2015. [online] Available at: < [Accessed 23 March 2022].
Rad-ar.or.jp. 2022. Search results detail| Kusurino-Shiori(Drug information Sheet). [online] Available at: < [Accessed 23 March 2022].
Information on this page was last updated on 6 Jan 2023
Disclaimer
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