Cyproheptadine

Description

Cyproheptadine is an antihistaminic medicine (class of medicine used to treat allergy). It is used to treat conditions like allergic rhinitis (irritation of nose), migraine, cluster headache, allergy of skin, etc. It works by blocking the release of histamine, a chemical messenger in the body that causes the symptoms of allergy. Cyproheptadine may cause side effects like dry mouth, nose, throat, drowsiness, dizziness, nausea, chest congestion, headaches, and muscle weakness. Consult your doctor if these side effects become worse or do not go away. Cyproheptadine can be taken with or without food at the same time regularly, in a dosage prescribed by your doctor. If you miss a dose, take it as soon as you remember. If your next scheduled dose time is approaching, skip the missing dose. Seek immediate medical attention if you have taken an overdose of this medicine as it can lead to symptoms like extreme drowsiness, hallucinations, very dry mouth, breathing difficulty, etc. Cyproheptadine may be safe to use during pregnancy. However, inform your doctor, if you are pregnant or intend to get pregnant while taking this medication. Avoid this medicine if you are breastfeeding as it is not known if it can pass into breast milk. Cyproheptadine is not recommended for use in children less than 2 years of age. Cyproheptadine can be very unsafe for newborn or premature babies. Cyproheptadine is not suitable for use if you have any kidney, liver issues, or have glaucoma. Avoid any activity that requires concentration such as driving or operating heavy machines if you are taking Cyproheptadine as it causes drowsiness.

Side effects

Major & minor side effects for Cyproheptadine

  • Vomiting
  • Nausea
  • Fatigue
  • Dizziness
  • Headache

Uses of Cyproheptadine

What is it prescribed for?

  • Allergic Rhinitis
  • Urticaria
  • Pruritus
  • Anorexia Nervosa
  • Migraine
  • Cluster headache
  • Cushing's syndrome
  • Allergic conjunctivitis
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Concerns

Commonly asked questions

  • Onset of action
    The effects of Cyproheptadine can be observed within 15 to 60 minutes of administration.
  • Duration of effect
    Cyproheptadine acts for an average duration of 8 to 12 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    Use of Cyproheptadine may be safe during pregnancy. However, it is recommended that you consult your doctor before taking this medicine. All the risks and benefits should be discussed before taking Cyproheptadine.
  • Usage while breast-feeding?
    Cyproheptadine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may suggest an alternative medicine based on your clinical condition.

Allergy

Cyproheptadine is not recommended for use in people with a known allergy to cyproheptadine or any other ingredients present in its formulations. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Narrow-angle glaucoma

Narrow-angle glaucoma is a condition that develops when the structure inside the eye that permits fluid to flow regularly from the eye (called the drainage angle) gets blocked. This leads to an increase in eye pressure and the risk of vision loss. Cyproheptadine is not recommended for use in people having narrow-angle glaucoma due to the increased risk of worsening of the patient's condition.

Monoamine oxidase inhibitors (MAO)

Monoamine oxidase inhibitors (MAO) is a group of medications used to treat a range of mental health conditions. Cyproheptadine is not recommended for use in people receiving therapy with MAO inhibitors due to the increased risk of serious side effects.

Symptomatic prostatic hypertrophy

Cyproheptadine is not recommended for use in people having symptomatic prostatic hypertrophy (prostate enlargement) due to the increased risk of worsening of the condition.

Elderly patients

Cyproheptadine is not recommended for use in elderly and debilitated (very weak) people due to the increased risk of serious side effects.
Warnings for special population

Pregnancy

Use of Cyproheptadine may be safe during pregnancy. However, it is recommended that you consult your doctor before taking this medicine. All the risks and benefits should be discussed before taking Cyproheptadine.

Breast-feeding

Cyproheptadine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may suggest an alternative medicine based on your clinical condition.
General warnings

Thyroid Disorder

Cyproheptadine should be used with caution in people who have thyroid dysfunction due to the increased risk of severe side effects. Regular monitoring of thyroid function tests is recommended for such people. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Renal impairment

Cyproheptadine is cleared from the body by the liver and kidneys, hence, it should be used with caution in people having kidney problems due to the increased risk of severe side effects. The kidney functions need to be closely monitored while on treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machines

Cyproheptadine may cause symptoms such as blurred vision, dizziness, drowsiness, tiredness, etc., in some people. It is advised that you do not perform activities such as driving vehicles or operating machines if you experience any of these symptoms during treatment with this medicine.

Use in Paediatrics

Cyproheptadine is not recommended for use in children less than 2 years of age since the safety and efficacy of use are not clinically established.

Liver impairment

Cyproheptadine is eliminated from the body by the liver and kidneys, hence the medicine should be used with caution in people having liver problems as it can increase the risk of severe side effects. The liver functions need to be closely monitored while receiving this medicine. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Propoxyphene

Sodium oxybate

Amoxapine

Aripiprazole

Topiramate

Zonisamide

Disease interactions

Asthma/ COPD

Cyproheptadine should be used with caution if you have a history of asthma/chronic obstructive pulmonary disease due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on your clinical condition.

Cardiovascular disorders

Cyproheptadine should be used with caution if you have a history of cardiovascular disorders due to the increased risk of worsening of your condition. Report any unusual symptoms to the doctor immediately. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on your clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Cyproheptadine can be taken with or without food. Do not consume Cyproheptadine in larger or smaller amounts than prescribed. Consult your doctor if you experience any undesirable side effects. Ensure that the Cyproheptadine treatment course is completed. Do not stop the use of Cyproheptadine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Cyproheptadine works by blocking the action of certain substances produced by the body which are responsible for causing allergic reactions and symptoms. It also blocks the actions of certain substances in the body which are responsible for a reduction in appetite.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antihistamines

Schedule

Schedule H

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 17 August 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/087056s045lbl.pdf>

CiplaMed. 2021. CIPLACTIN Tablets. [online] Available at: < [Accessed 17 August 2021].

https://ciplamed.com/content/ciplactin-tablets>

Drugs, H., 2021. Cyproheptadine: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 17 August 2021].

https://medlineplus.gov/druginfo/meds/a682541.html>

Pubchem.ncbi.nlm.nih.gov. 2021. Cyproheptadine. [online] Available at: < [Accessed 17 August 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/2913>

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Information on this page was last updated on 7 Oct 2021

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.