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Cycram 500 mg Injection

Manufactured by: Vhb Life Sciences Inc
Composition: Cyclophosphamide
Prescription Required: Yes
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Description

Cycram 500 mg Injection is an anticancer agent which is used in the treatment of various cancers of the blood and the female reproductive system. It should be used under the supervision of a qualified physician. Close monitoring of kidney function and blood cell count is necessary while receiving this medication.

Side effects

Major & minor side effects for Cycram 500 mg Injection

  • Infectionssevere
  • Decrease in blood cell countsevere
  • Hair losssevere
  • Feversevere
  • Weaknesssevere
  • Loss of appetite
  • Nausea and Vomiting
  • Diarrhea
  • Headache
  • Increased sweating
  • Skin rash
SEVERE
Contact your doctor immediately if any of these symptoms are experienced on a regular basis.
RARE
Observed in a small fraction of population.
This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Highlights

Commonly asked questions for Cycram 500 mg Injection

Onset of action

The effect of this medicine can be observed in 2 to 3 hours after an oral dose.

Duration of effect

The effect of this medicine lasts for an average duration of 12 to 24 hours.

Safe with alcohol?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is it habit forming?

No habit forming tendency has been reported.

Usage in pregnancy?

This medicine is not recommended for use in pregnant women.

Usage while breast-feeding?

This medicine is not recommended for use in breastfeeding women.

Substitutes

List of substitutes for Cycram 500 mg Injection

Below is the list of medicines, which have the same composition, strength and form as Cycram 500 mg Injection, and hence can be used as its substitute.
Cycloxan 500 mg Injection
Zydus Cadila
Cyphos 500 mg Injection
Intas Pharmaceuticals Ltd.
Endoxan 500 mg Injection
Zydus Cadila
Endoxan N 500 mg Injection
Zydus Cadila
Oncophos 500 mg Injection
Cadila Pharmaceuticals Ltd.

What is it prescribed for?

Uses of Cycram 500 mg Injection

  • Malignant Disease

    Cycram 500 mg Injection is used in the treatment of cancers like Hodgkin’s disease, lymphocytic lymphoma, etc.

  • Ovarian Cancer

    Cycram 500 mg Injection is used in the treatment of the cancer that affects the female reproductive system.

  • Breast cancer

    Cycram 500 mg Injection is used in the treatment of breast cancer.

  • Nephrotic Syndrome

    In pediatrics, if the nephrotic syndrome does not respond adequately to steroid treatments or if the steroids produce intolerable side effects, Cycram 500 mg Injection is used to treat the condition.

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When not to use?

Contraindications of Cycram 500 mg Injection

  • Allergy

    Not recommended in patients with known allergy to Cycram 500 mg Injection or other alkylating agents.

  • Urinary outflow obstruction

    Not recommended in patients with conditions that obstruct the urine outflow.

  • Bone marrow suppression

    Not recommended in patients with low blood cell counts.

Dosage

  • Missed Dose

    It is advised not to miss any dose. If you miss any dose, you should contact your doctor immediately.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

  • Description

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Instructions

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Disease interactions

  • Disease

    Information not available.

Food interactions

  • Information not available.

Lab interactions

  • Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

General Instructions

Take this medicine as advised by the doctor. It should be given in multiple cycles along with other chemotherapy agents. It is important to receive every scheduled dose. The blood cells count and kidney function should be assessed before starting the treatment. Any signs and symptoms of heart and lung dysfunction should be reported to the doctor on priority.

Warnings

Warnings for special population

  • Pregnancy

    - This medicine is not recommended for use in pregnant women.

  • Breast-feeding

    - This medicine is not recommended for use in breastfeeding women.

General warnings

  • Secondary Malignancies

    - Cycram 500 mg Injection is known to increase the risk of secondary tumors. Most frequently, the urinary tract, thyroid gland, and blood are affected. Close monitoring of signs and symptoms is necessary. The treatment should be discontinued if malignancy develops.

  • Blood cell count

    - Cycram 500 mg Injection is known to lower the white blood cell count (neutrophils) and platelets. Close monitoring of blood cell counts is necessary. Do not start the treatment if the neutrophils count is less than 1500 cells/mm3 and platelets count is less than 50,000 cells/mm3.

  • Effect on heart

    - Cycram 500 mg Injection may increase the risk of toxic effects on the heart and could lead to congestive heart failure. The treatment should be monitored in patients with a history of heart disease.

  • Effect on lungs

    - Cycram 500 mg Injection may increase the risk of toxic effects on lungs and could lead to respiratory failure. Any symptoms of lung toxicity should be informed to the doctor on priority. The treatment should be discontinued if such symptoms appear.

  • Infections

    - The chances of infections are more in patients receiving this medicine. Hold the chemotherapy and start with broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

  • Impaired kidney function

    - Cycram 500 mg Injection is known to increase kidney injury and increases the risk of secondary cancers. It should be used with caution in patients with urinary tract infections. The treatment should be discontinued if the signs and symptoms of kidney injury appear.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken as instructed by doctor
  • Does not cause sleepiness

How it works

It works by interfering with the DNA synthesis and inhibiting the tumor growth.

Legal Status

Approved
Approved
Approved
Approved

Classification

Category
Alkylating agents
Schedule
Schedule G

References

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Information on this page was last updated on 8 Jan 2018

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Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.