Cycloserine

Description

Cycloserine is an antibiotic used to treat active pulmonary and extra-pulmonary tuberculosis (including renal disease) caused by the susceptible organisms in patients who failed to respond with the conventional therapy. This medicine is usually given in combination with other effective therapeutic agents. This medicine may also be used for the treatment of urinary tract infections in adult patients who are not responding to the primary treatment.

Side effects

Major & minor side effects for Cycloserine

  • Anxiety
  • Dizziness and Drowsiness
  • Mental depression
  • Nervousness
  • Irritability
  • Muscle tremor
  • Change in mood
  • Nightmares
  • Headache

Uses of Cycloserine

What is it prescribed for?

  • Tuberculosis
  • Urinary Tract Infection
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed within 4-8 hours of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to cycloserine or any other inactive ingredients present along with this medicine.

Epilepsy

This medicine is not recommended for use in patients who have a history of epilepsy or seizures due to the increased risk of worsening of the patient's condition.

Psychiatric problems

This medicine is not recommended for use in patients who have depression, severe anxiety, or psychosis due to the increased risk of worsening of the patient's condition.

Renal dysfunction

This medicine is not recommended for use in patients who have severe renal dysfunction due to the increased risk of worsening of the patient's condition.

Alcohol abuse

This medicine is not recommended for use in patients who have severe alcoholism due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Alcohol use

Excessive concurrent use of alcohol is contraindicated while on treatment with this medicine. The risk of seizures is high in patients with the history of alcoholism.

CNS toxicity

This medicine should be discontinued or dose should be reduced if the patient experiences any central nervous system toxicity such as convulsions, psychosis, sleepiness, depression, confusion, headache, tremor, vertigo, etc.

Culture and sensitivity

Before initiating treatment with this medicine, cultures should be taken and the susceptibility of the organism to the medicine should be established. In tuberculous infections, sensitivity to the other anti-tuberculous agents in the regimen should also be demonstrated.

Driving and Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Laboratory tests

Close monitoring of blood levels of this medicine is necessary, especially in patients with an impaired kidney function. Blood levels of greater than 30 mg/L are associated with toxicity. The dosage adjustments should be done to keep the blood levels of this medicine below 30 mg/L to avoid the undesired outcomes.

Vitamin B12 and/or folic acid deficiency

Cycloserine and other antituberculous drugs have been associated with vitamin B12 and/or folic acid deficiency, megaloblastic anemia, and sideroblastic anemia. If evidence of anemia develops during treatment, appropriate investigations and corrective treatment should be initiated.

Kidney disease

This medicine should be used with caution in patients with kidney disease due to the increased risk of adverse effects. Regular monitoring of the kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Tramadol

Live cholera vaccine

Bupropion

Fluphenazine

Sodium biphosphate

Disease interactions

Colitis

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
This medicine works by inhibiting bacterial cell wall synthesis; this stops the growth of the bacteria and ultimately leads to their death.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antituberculosis agents, Streptomyces derivatives

Schedule

Schedule H1

[Internet]. Dailymed.nlm.nih.gov. 2018 [cited 14 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e1e08327-4b90-463e-bb2a-22438cabcef2

[Internet]. Medicines.org.uk. 2018 [cited 14 September 2018]. Available from:

https://www.medicines.org.uk/emc/product/2252

[Internet]. Drugbank.ca. 2018 [cited 14 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00260

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Information on this page was last updated on 7 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.