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CTD M 12.5/50MG TABLET
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CTD M 12.5/50MG TABLET

Manufactured byIpca Laboratories Pvt. Ltd.
ContainsMetoprolol (50 mg) + Chlorthalidone (12.5 mg)
Description
CTD M 12.5/50MG TABLET is a combination medicine used for the treatment of a mild to moderate increase in the blood pressure. Frequent monitoring of blood pressure and electrolytes levels is necessary during treatment with this medicine. Patients are advised to follow a strict exercise and diet regimen along with this medicine to get the best possible effect.
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Side effectsConcernsUsage

Substitutes

List of substitutes for CTD M 12.5/50MG TABLET

Starcad CT 50 Tablet
Lupin Ltd.
SUSTAMETO CH 50 TABLET
Zydus Cadila

Side effects

Major & minor side effects for CTD M 12.5/50MG TABLET

  • Very low blood pressure
  • Photosensitivity
  • Constipation
  • Diarrhea
  • Loss of appetite
  • Headache
  • Blurred vision
  • Restlessness
  • Chest pain and discomfort
  • Dizziness
  • Slow heart beat
  • Shortness of breath
  • Nausea or vomiting
  • Skin rash

Uses of CTD M 12.5/50MG TABLET

What is it prescribed for?

  • Mild to moderate essential hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 to 72 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to chlorthalidone, other sulfonamides, metoprolol, other beta-blockers, or any other inactive ingredients present along with these medicines.

Anuria

This medicine is not recommended for use in patients with anuria, a condition where the kidney is unable to produce urine.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (CrCl < 30 ml/min) due to the increased risk of serious adverse effects.

Severe liver impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of serious adverse effects.

Heart diseases

This medicine is not recommended for use in patients with serious heart problems such as a heart block, heart failure, sick sinus syndrome, etc. due to the increased risk of worsening of the patient's condition.

Circulatory disorders

This medicine is not recommended for use in patients suffering from blood circulation disorders since it may worsen the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Volume and electrolyte disturbances

This medicine may alter the blood volume and electrolytes levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolytes levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Renal impairment

This medicine should be used with caution in patients with a known history of renal diseases due to the increased risk of worsening of the patient's condition. Close monitoring of renal function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Driving or operating machines

This medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating heavy machinery during treatment with this medicine if you experience any of these symptoms.

Ischemic Heart Disease

This medicine should not be discontinued abruptly in patients suffering from ischemic heart disease since abrupt discontinuation may worsen the patient's condition. The dosage should be reduced gradually over a period of 1 to 2 weeks along with close monitoring of heart function before discontinuation of therapy.

Major surgery

This medicine should be used with extreme caution in patients undergoing a major surgery due to the increased risk of severe adverse effects. Close monitoring of heart function is recommended for such patients.

Pheochromocytoma

This medicine should be administered with extreme caution in patients suffering from pheochromocytoma, a condition which results in an excess of a substance that controls heartbeat and blood pressure. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Bronchospastic Disease

This medicine should be administered with caution in patients with a disease of the lung or the airways leading to the lungs such as pneumonia, asthma, or chronic obstructive pulmonary disease. Close monitoring of lung function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperthyroidism

This medicine should be administered with caution in patients suffering from hyperthyroidism since it may mask some of the patient's symptoms. Close monitoring of thyroid hormone levels is recommended for such patients. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Heart Failure

This medicine may cause heart failure and reduced flow of blood in some patients. This risk is especially higher in patients with a history of heart diseases. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Peripheral Vascular Diseases

This medicine should be used with caution in patients suffering from peripheral vascular diseases since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Sports

Athletes are advised not to indulge in certain sports while using this medicine. Archery, racing, shooting and other high-risk sports should be avoided. Sportspersons should refer to the list of medicines published by World Anti-Doping Agency (WADA) which are not to be taken while participating in certain specific sports events.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Amlodipine

Cisapride

Diltiazem

Lithium

Amiodarone

Insulin

Aminophylline

Ergotamine

Ziprasidone

Disease interactions

Diabetes

This medicine should be used with caution in patients with a known history of diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Hyperuricemia

This medicine should be used with caution in patients with hyperuricemia since this medicine decreases the uric acid excretion. This may cause serious side effects. Appropriate dose adjustments or replacement with a suitable alternative should be considered under your doctor's supervision.

Hyperlipidemia

This medicine should be used with caution in patients with hyperlipidemia since it may increase the cholesterol and triglyceride levels. Close monitoring of cholesterol and triglyceride levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Asthma

This medicine is not recommended for use in patients with bronchial asthma or chronic obstructive pulmonary disease since it may worsen the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Heart Block

This medicine is not recommended for use in patients with a heart block greater than the first degree unless a permanent pacemaker is present. Replacement with a suitable alternative should be considered under your doctor's supervision.

Liver disease

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Glaucoma

This medicine should be administered with caution in patients suffering from glaucoma. A change in the dose of the current glaucoma medicine may be required in some cases. Replacement with a suitable alternative may be necessary based on the clinical condition.
Food interactions
Coadministration of multivitamin with minerals and this combination medicine may decrease the effects of this medicine. Close monitoring of blood pressure and appropriate dose adjustments may be necessary in some cases based on the clinical condition. Your doctor may advise you to maintain an appropriate time gap between the consumption of multivitamin with minerals and this medicine to minimize their interaction.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as advised by your doctor. Do not take in larger or smaller amounts than prescribed. It is advised to take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Metoprolol relaxes the blood vessels and reduces the heart rate, promoting a smooth flow of blood. Chlorthalidone increases the excretion of water and sodium from the kidneys. Their combination is thus effective in reducing the blood pressure.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Cardioselective beta blockers, Thiazide diuretics, Cardioselective beta blockers with thiazides, Antihypertensive combinations

Schedule

Schedule H

[Internet]. 2017 [cited 6 March 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/152

DailyMed - Metoprolol - metoprolol tartrate injection, solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 6 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be1c686e-37a5-4a53-945b-68a6ead35134

Chlorthalidone - DrugBank [Internet]. Drugbank.ca. 2017 [cited 19 October 2017]. Available from:

https://www.drugbank.ca/drugs/DB00310

DailyMed - Chlorthalidone tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 19 October 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=193c85ba-43c2-4be2-82cf-7b394a83390e

[Internet]. 2017 [cited 19 October 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.29309.latest.pdf
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Information on this page was last updated on 15 May 2018

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