Crizotinib

Description

Crizotinib is used for the treatment of Non-small cell lung cancer (NSCLC), which is a type of cancer that affects the lungs. This medicine is not recommended for use in patients below 18 years of age.

Side effects

Major & minor side effects for Crizotinib

  • Black or tarry stools
  • Body aches or Pain
  • Cough
  • Chest pain or discomfort
  • Fever or chills
  • Headache
  • Rapid weight gain
  • Difficulty or painful urination
  • Blood in urine and stools
  • Pale skin
  • Change in taste
  • Decreased appetite

Uses of Crizotinib

What is it prescribed for?

  • Non-Small Cell Lung Cancer
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to Crizotinib or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Hepatic impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Renal Impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Gastrointestinal Diseases

This medicine should be used with extreme caution in patients suffering from stomach or intestine problems due to the increased risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Bradycardia

This medicine may cause bradycardia (decreased heart rate) and therefore it is recommended to monitor heart rate and blood pressure regularly. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Visual loss

This medicine may cause visual loss and should be used with extreme caution in patients with visual defects or disturbances due to the risk of worsening of the patient's condition. It is recommended to perform ophthalmic tests in such patients while receiving this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Driving or Operating machinery

Use of this medicine may cause dizziness, visual disturbances, and tiredness. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery during treatment with this medicine.

QT interval prolongation

This medicine should be used with extreme caution in patients who have or may develop prolongation of QT interval due to the increased risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. But do not take a missed dose within 6 hours of the next dose. Contact your doctor for further instructions if you miss more than one scheduled dose of this medicine.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Escitalopram

Atazanavir

Amoxapine

Ofloxacin

Fluconazole

Cisapride

Disease interactions

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Hepatic impairment

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Lung impairment

This medicine should be used with caution in patients with a history of interstitial lung disease presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation due to the increased risk of the lung toxicity. Close monitoring of lung function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Avoid consumption of grapefruit or grapefruit juice while taking this medicine since it may cause severe adverse effects. Report to your doctor, if you experience any adverse effects such as irregular heart rhythm, diarrhea, nausea, vomiting, abdominal pain, and high blood sugar, etc.
Lab interactions
Information not available.
Take this medicine with or without food, as advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Effect on sleep is not established

How it works
This medicine works by inhibiting the actions of certain abnormal proteins that cause the cancer cells to multiply. This helps in stopping the growth and spread of cancer.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Multikinase inhibitors, Antineoplastics

Schedule

Schedule H

Crizotinib: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 4 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a612018.html

[Internet]. Accessdata.fda.gov. 2018 [cited 4 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202570s002lbl.pdf

[Internet]. Medicines.org.uk. 2018 [cited 4 December 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.2857.pdf

Crizotinib - DrugBank [Internet]. Drugbank.ca. 2018 [cited 4 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB08865

[Internet]. Xalkori.com. 2018 [cited 4 December 2018]. Available from:

https://www.xalkori.com/sites/default/files/pdf/Welcome%20Brochure.pdf

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Information on this page was last updated on 6 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.