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Coversyl Plus HD Tablet
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Coversyl Plus HD Tablet

Manufactured bySERDIA PHARMACEUTICALS (INDIA) PVT LTD
ContainsPerindopril (8 mg) + Indapamide (2.5 mg)
Description
Coversyl Plus HD Tablet is a combination of Perindopril and Indapamide. This medicine is used for the treatment of hypertension (high blood pressure). It works by relaxing your blood vessels, which makes the blood flow easily, thus reduces your blood pressure. This will also reduce the risk of heart attack or a stroke (brain damage due to interrupted blood flow) by making it easier for your heart to pump blood around your body. Coversyl Plus HD Tablet shows some common side effects like decreased blood pressure, dizziness, back pain, cough, weakness, etc. These side effects are temporary and will go away gradually. However, if you have persistent vomiting and/or diarrhoea, as well as excessive sweating, you should inform your doctor. Coversyl Plus HD Tablet contains Indapamide (water pill) which causes frequent urination. Take this medicine on an empty stomach in the morning to avoid frequent urination at night. To avoid any missed dose, take this medicine at the same time every day. Even if you feel better or your blood pressure appears to be under control, do not stop taking it. Abrupt discontinuation may lead to side effects or a sudden increase in your blood pressure. This medicine is safe for long term use. Coversyl Plus HD Tablet is only recommended if you are 18 years old or above. Inform your doctor if you have any history of kidney, liver and heart problems or any other condition. You should also tell your doctor about any other medications you are taking, particularly those used to treat high blood pressure or heart problems. Pregnant women should not use this medication since it might harm the foetus, especially if taken during the second and third trimesters.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Coversyl Plus HD Tablet

  • Dizziness
  • Headache
  • Weakness
  • Cough
  • Back pain
  • Very low blood pressure
  • Indigestion
  • Ringing in ears

Uses of Coversyl Plus HD Tablet

What is it prescribed for?

  • Hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Coversyl Plus HD Tablet starts to work in your body within two hours of taking it orally and reduces high blood pressure. However, to see its full effect, you need to take this medicine for at least a month.
  • How long do the effects of this medicine last?
    The amount of time for which Coversyl Plus HD Tablet remains active in the body is about 6 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Coversyl Plus HD Tablet due to the increased risk of adverse effects such as dizziness, fainting, very low blood pressure, etc.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Coversyl Plus HD Tablet.
  • Can this medicine be taken during pregnancy?
    Avoid Coversyl Plus HD Tablet during pregnancy since it causes harm to the foetus, especially if taken during the second and third trimesters.
  • Can this medicine be taken while breast-feeding?
    Do not take Coversyl Plus HD Tablet as it is unknown if the medicine passes into breastmilk. You should consult your doctor before using this medicine to understand all risks and benefits.

Allergy

Avoid taking Coversyl Plus HD Tablet if you are allergic to Indapamide, Perindopril, any other ACE inhibitors (medicines used for reducing high blood pressure) or any other ingredients present along with these medicines. This could lead to symptoms like redness, swelling, breathing difficulty, hives (itchy, painful eruptions that sting), etc. You should ask your doctor for another alternative if you have a known history of allergy to this medicine.

Angioedema

Angioedema is an allergic condition in which there is painless swelling under the skin, mostly seen around the face and lips. Coversyl Plus HD Tablet is not recommended for use if you have a known history of angioedema as it may worsen your condition.

Aliskiren

Aliskiren is a medicine used to reduce high blood pressure. Do not use Coversyl Plus HD Tablet if you are taking Aliskiren. Concomitant use of these medicines may lead to serious side effects such as low blood pressure, and high potassium levels in your blood. The risk is higher if you have a kidney problem or diabetes (high blood sugar level).

Anuria

Anuria is a condition where the kidney is unable to produce urine. Coversyl Plus HD Tablet is not recommended for use if you have such a condition as it may worsen your condition.

Sacubitril

Sacubitril is a medicine used in the treatment of heart failure. It is recommended that you should not take Coversyl Plus HD Tablet within 36 hours before or after taking a medicine that contains Sacubitril.
Warnings for special population

Pregnancy

Avoid Coversyl Plus HD Tablet during pregnancy since it causes harm to the foetus, especially if taken during the second and third trimesters.

Breast-feeding

Do not take Coversyl Plus HD Tablet as it is unknown if the medicine passes into breastmilk. You should consult your doctor before using this medicine to understand all risks and benefits.
General warnings

Hypotension

Coversyl Plus HD Tablet may cause hypotension (decrease in blood pressure), especially when used in combination with other high blood pressure medicines and also if you are having low sodium levels in your blood. During therapy with this medication, you should check your blood pressure regularly. Depending on your clinical condition, your doctor may make appropriate dose changes.

Volume and electrolyte depletion

Coversyl Plus HD Tablet may alter the blood volume and electrolytes levels which may lead to dizziness, dry mouth, and acid-base imbalance (balance between acidity and alkalinity in your body). Your blood pressure and electrolytes levels need to be closely monitored during the treatment with this medicine. If you experience any symptoms like weakness, muscle pain, lethargy, drowsiness, dizziness, etc., inform your doctor immediately.

Driving and operating machines

Coversyl Plus HD Tablet may affect your driving ability as it can lead to dizziness or weakness due to low blood pressure. After taking this medication, it is advised that you do not perform activities that require high mental alertness such as driving vehicles or operating machines.

Liver diseases

Coversyl Plus HD Tablet should be used with caution if you have a history of liver problems due to the increased risk of liver failure. Get your liver function tests regularly done while you are on this medication. Inform your doctor if you develop any symptoms of jaundice (increased level of bilirubin, a blood pigment that leads to yellow skin discolouration].

Lupus Erythematosus

Lupus erythematosus is an autoimmune disorder (a condition in which the immune system mistakenly attacks its own body). Take Coversyl Plus HD Tablet with caution as it may activate the symptoms of lupus erythematosus like joint pain, rash, fever and fatigue.

Surgery and anesthesia

Coversyl Plus HD Tablet should be used with caution if you are about to undergo surgery as it may increase the risk of very low blood pressure. Before undergoing any surgery or anaesthesia, you should inform the doctor/surgeon about all of your current medicines. Based on your clinical condition, your doctor will recommend dose adjustments or replacements with a suitable alternative.

Kidney disease

Coversyl Plus HD Tablet should be used with caution if you have a history of kidney problems. This medicine is excreted via the kidney and it may get accumulated in your body if there is a pre-existing kidney problem.

Missed Dose

If you forgot to take the dose of Coversyl Plus HD Tablet at a given time, then take it as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Never take more than the prescribed dose of Coversyl Plus HD Tablet. If you suspect that you might have taken an overdose of this medicine, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Coversyl Plus HD Tablet due to the increased risk of adverse effects such as dizziness, fainting, very low blood pressure, etc.
Interaction with Medicine

Insulin

Amiodarone

Cisapride

Allopurinol

Lithium

Diclofenac

Disease interactions

Asthma

Coversyl Plus HD Tablet should be used with caution if you have bronchial asthma (a condition in which air passage is swollen in your lungs that causes breathing difficulty) as it may increase the risk of sensitivity reactions. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on your clinical condition.

Diabetes

Coversyl Plus HD Tablet should be used with caution if you have Diabetes mellitus (increased blood sugar level) as it may alter your blood sugar levels. Close monitoring of blood sugar levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on your clinical condition.

Bone marrow suppression

Bone marrow suppression is a condition in which your bone marrow (a substance found in the bone that produces blood cells) activity is reduced which further leads to a decrease in blood cell count. If you are diagnosed with such a condition, take Coversyl Plus HD Tablet with caution. This medicine cause bone marrow suppression and the risk is high if you have kidney impairment.

Congestive heart failure

Congestive heart failure (CHF) is a condition in which the heart is unable to pump blood efficiently. If Coversyl Plus HD Tablet is taken in such conditions it can lead to serious effects on your kidney which may lead to oliguria (low urine output) and kidney failure.

Hemodialysis

Hemodialysis is a treatment in which a machine is used to filter the waste from the blood when the kidney fails to do so. If you are undergoing hemodialysis, take Coversyl Plus HD Tablet with caution. This medicine may lead to anaphylactoid reactions (allergic reactions) in such conditions.

Hyperkalemia

Coversyl Plus HD Tablet may significantly increase the potassium levels in your blood (hyperkalemia). This may cause side effects such as irregular heartbeats. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on your clinical condition.
Food interactions
It is recommended to avoid a high potassium diet during treatment with Coversyl Plus HD Tablet due to the increased risk of side effects. Unless recommended by your doctor, do not take salt substitutes or potassium supplements while taking this medicine. Your doctor/dietitian will suggest an appropriate diet for you to avoid a high intake of potassium.
Lab interactions

Thyroid function tests

Coversyl Plus HD Tablet may decrease the serum protein-bound iodine levels. This factor should be taken into account when interpreting thyroid function test results. Inform your doctor about all your current medications before undergoing thyroid function tests.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Coversyl Plus HD Tablet exactly as instructed by your doctor. You are advised to take this medicine before food. Do not take in larger or smaller amounts than the prescribed dose. Consult your doctor if there are any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor. This medicine may make you feel dizzy. If you have been sitting or lying down, stand up carefully to reduce the risk of dizziness. Inform your doctor if you have a persistent cough or throat irritation. Coversyl Plus HD Tablet may also cause dehydration. Drink a lot of fluids and inform your doctor if you feel extremely thirsty and have a dry mouth. While you are taking this medication, your doctor may check your blood pressure, kidney function, and the levels of salts such as potassium in your blood on a regular basis.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
Coversyl Plus HD Tablet contains Perindopril and Indapamide in it. Perindopril relaxes your blood vessels and promotes a smooth flow of blood. Indapamide works by increasing the excretion of water and sodium from your kidneys. Both these actions help in reducing blood pressure.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

ACE inhibitors with thiazides

Schedule

Schedule H

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https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fcaefca9-e6ca-4c97-9eb8-7f1c619ce4d0>

Drugs, H., 2021. Perindopril: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 4 August 2021].

https://medlineplus.gov/druginfo/meds/a602017.html>

Medicines.org.uk. 2021. Perindopril Erbumine 4 mg tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 4 August 2021].

https://www.medicines.org.uk/emc/product/4390/smpc#gref>

Dailymed.nlm.nih.gov. 2021. DailyMed - INDAPAMIDE tablet. [online] Available at: < [Accessed 5 August 2021].

https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=788ebfde-39a2-42a4-9bd6-34ad87f66a97>
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Information on this page was last updated on 7 Oct 2021

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