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Coversyl Plus
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Coversyl Plus

Manufactured bySerdia Pharmaceuticals (India) Pvt. Ltd.
ContainsPerindopril (4 mg) + Indapamide (1.25 mg)
Description
Coversyl Plus is a combination of Perindopril and Indapamide. This medicine is used in the treatment of high blood pressure. It works by relaxing your blood vessels and increasing the water and sodium excretion from your body. Thus, it controls your blood pressure. Coversyl Plus also reduces the risk of heart attack or stroke (brain damage due to interrupted blood flow) by making it easier for your heart to pump blood throughout your body. Coversyl Plus shows common side effects like dizziness, back pain, cough, tiredness, weakness, decreased blood pressure, etc. These side effects are temporary and will go away with time. However, if you have persistent vomiting and/or diarrhoea, as well as excessive sweating, you should see a doctor. Coversyl Plus is recommended to be taken before a meal or as advised by your doctor. This medicine contains Indapamide (water pill) which causes frequent urination. Take this medicine in the morning or four hours before bedtime to avoid frequent urination at night. Coversyl Plus should be taken at the same time every day to avoid any missed dose. Even if you feel better or your blood pressure appears to be under control, do not stop taking it. Abrupt discontinuation may lead to side effects or a sudden increase in your blood pressure. This medicine is safe for long-term use. Coversyl Plus is only recommended if you are 18 years or above. Inform your doctor if you have a history of kidney, liver, and heart problems. Inform your doctor about any other medications you are taking, particularly those used to treat high blood pressure or heart problems. This medicine is not recommended if you are pregnant as it may cause harm to your unborn foetus, especially if taken during the second and third trimesters. To ensure that this medicine is working effectively, you should have your blood pressure, kidney function, and salt levels such as potassium tested on a regular basis.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Coversyl Plus

  • Headache
  • Dizziness
  • Weakness
  • Cough
  • Diarrhoea
  • Back pain
  • Very low blood pressure

Uses of Coversyl Plus

What is it prescribed for?

  • Hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Coversyl Plus starts to work in your body within a few hours and reduces high blood pressure. However, to see its full effect, you need to take this medicine for at least a month.
  • How long do the effects of this medicine last?
    Coversyl Plus remains active in your body for approximately 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Coversyl Plus. Alcohol may increase the risk of adverse effects such as dizziness, fainting, very low blood pressure, etc.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported for Coversyl Plus.
  • Can this medicine be taken during pregnancy?
    Coversyl Plus should not be used during pregnancy since it may cause harm to your foetus, especially if taken during the second and third trimesters.
  • Can this medicine be taken while breast-feeding?
    Do not take Coversyl Plus as it is unknown if the medicine passes into breastmilk. You should consult your doctor before using this medicine to understand all risks and benefits.

Allergy

Avoid taking Coversyl Plus if you are allergic to Indapamide, Perindopril, any other ACE inhibitors, diuretics, or any other ingredients present in this medicines. This could lead to symptoms like redness, swelling, breathing difficulties, hives (itchy, painful eruptions that sting), etc. You should ask your doctor for another alternative if you have a known history of allergy to this medicine.

Angioedema

Angioedema is an allergic condition in which there is painless swelling under the skin, mostly seen around the face and lips. Coversyl Plus is not recommended for use if you have a history of angioedema as it may worsen your condition.

Aliskiren

Aliskiren is a medicine used to reduce high blood pressure. Do not use Coversyl Plus if you are taking Aliskiren. Concomitant use of these medicines may lead to serious side effects such as low blood pressure, and high potassium levels in your blood. The risk is higher if you have a kidney problem or diabetes (high blood sugar level).

Sacubitril

Sacubitril is a medicine used in the treatment of chronic heart failure (a condition in which the heart is not able to pump a sufficient amount of blood). It is recommended that you should not take Coversyl Plus within 36 hours before or after taking a medicine that contains sacubitril as it may lead to angioedema (swelling of the face, eye, lips, etc.).

Anuria

Anuria is a condition where the kidney is unable to produce urine. Coversyl Plus is not recommended for use if you have such a condition as it may worsen your condition.
Warnings for special population

Pregnancy

Coversyl Plus should not be used during pregnancy since it may cause harm to your foetus, especially if taken during the second and third trimesters.

Breast-feeding

Do not take Coversyl Plus as it is unknown if the medicine passes into breastmilk. You should consult your doctor before using this medicine to understand all risks and benefits.
General warnings

Hypotension

Hypotension refers to a decrease in blood pressure. Coversyl Plus may cause hypotension, especially when used in combination with other high blood pressure medicines and/or if you have low sodium levels in your blood. During treatment with this medication, you should check your blood pressure regularly. Depending on your clinical condition, the doctor may make appropriate dose changes.

Volume and electrolyte depletion

Coversyl Plus may alter the blood volume and electrolytes levels. Your blood pressure and electrolytes levels need to be closely monitored during the treatment with this medicine. If you experience any symptoms like weakness, muscle pain, lethargy, drowsiness, dizziness, etc., inform your doctor immediately.

Driving and operating machines

Coversyl Plus may affect your driving ability as it can lead to dizziness or weakness due to low blood pressure. After taking this medication, avoid performing activities that require high mental alertness such as driving vehicles or operating machines.

Liver diseases

Coversyl Plus should be used with caution if you have a history of liver problems due to the increased risk of liver failure. Get your liver function tests regularly done while you are on this medication. Inform your doctor if you develop any symptoms of jaundice (increased level of bilirubin, a blood pigment that leads to yellow skin discolouration).

Lupus Erythematosus

Lupus erythematosus is an autoimmune disease (immune system attacks its own tissues) that causes inflammation and tissue damage in the affected organs. Take Coversyl Plus with caution as it may worsen the condition and activate the symptoms of lupus erythematosus such as joint pain, rash, fever, and fatigue.

Surgery and anesthesia

Coversyl Plus should be used with caution if you are about to undergo surgery as it may increase the risk of very low blood pressure when used with certain anaesthesia. Before undergoing any surgery or anaesthesia, you should inform your doctor/surgeon about all of your current medicines. Based on your clinical condition, your doctor may recommend discontinuation of the medicine before surgery or use a suitable alternative.

Kidney disease

Coversyl Plus should be used with caution if you have a history of severe kidney problems. This medicine is excreted via the kidney and its metabolites may get accumulated in your body if there is kidney impairment.

Missed Dose

If you forgot to take the dose of Coversyl Plus at a given time, then take it as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Never take more than the prescribed dose of Coversyl Plus. If you suspect that you might have taken an overdose of this medicine, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Coversyl Plus. Alcohol may increase the risk of adverse effects such as dizziness, fainting, very low blood pressure, etc.
Interaction with Medicine

Allopurinol

Cisapride

Lithium

Amiodarone

Insulin

Diclofenac

Disease interactions

Asthma

Coversyl Plus should be used with caution if you have bronchial asthma (a condition in which air passage is swollen and narrowed that causes breathing difficulty) as it may increase the risk of sensitivity reactions such as breathing difficulty, tightening of the chest, etc. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on your clinical condition.

Diabetes

Coversyl Plus should be used with caution if you have Diabetes mellitus (increased blood sugar level) as it may alter your blood sugar levels. Close monitoring of blood sugar levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on your clinical condition.

Bone marrow suppression

Bone marrow suppression is a condition in which your bone marrow (a substance found in the bone that produces blood cells) activity is reduced which further leads to a decrease in blood cell count. If you are diagnosed with such a condition, take Coversyl Plus with caution. This medicine causes bone marrow suppression and the risk is high if you have kidney impairment.

Congestive heart failure

Congestive heart failure (CHF) is a condition in which the heart is unable to pump blood efficiently. If Coversyl Plus is taken in such conditions it can lead to serious effects on your kidney, which may lead to oliguria (low urine output) and kidney failure. Your doctor may suggest tests to monitor the functioning of your heart and kidneys while you are taking this medicine.

Haemodaialysis

Haemodialysis is a treatment in which a machine is used to filter the waste from the blood when the kidney fails to do so. If you are undergoing hemodialysis, take Coversyl Plus with caution. This medicine may lead to anaphylactoid reactions (life-threatening allergic reactions) in such conditions.

Hyperkalaemia

Coversyl Plus may significantly increase the potassium levels in your blood (hyperkalaemia). This may cause serious adverse effects such as irregular heartbeats. Report any unusual symptoms to your doctor immediately. Avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (potassium-sparing diuretics and potassium supplements) during treatment with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on your clinical condition.
Food interactions
It is recommended to avoid a high potassium diet during treatment with Coversyl Plus due to the increased risk of serious side effects. Unless recommended by your doctor, do not take salt substitutes or potassium supplements while taking this medicine. Your doctor/dietitian will suggest an appropriate diet for you to avoid a high intake of potassium.
Lab interactions

Thyroid function tests

Coversyl Plus may decrease the serum protein-bound iodine levels. This factor should be taken into account when interpreting thyroid function tests' results. Inform your doctor about all your current medicines before undergoing thyroid function tests.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Coversyl Plus medicine before food or as instructed by your doctor. You should not take the medicine in larger or smaller amounts than prescribed. Ensure that you complete the entire course of treatment. It is not recommended to discontinue this medicine without consulting your doctor. Consult your doctor if you experience any undesirable side effects that bother you. This medicine may make you feel dizzy. If you have been sitting or lying down, stand up slowly to reduce the risk of dizziness. Inform your doctor if you have a persistent cough or throat irritation. Coversyl Plus may also cause dehydration. Drink lots of fluids and inform your doctor if you feel extremely thirsty and have a dry mouth. While you are taking this medication, your doctor may check your blood pressure, kidney function, and the levels of salts such as potassium in your blood regularly.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
Coversyl Plus consists of Perindopril and Indapamide which work together in reducing blood pressure. Perindopril relaxes your blood vessels and promotes a smooth flow of blood. Indapamide works by increasing the excretion of water and sodium from your kidneys.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

ACE inhibitors with thiazides

Schedule

Schedule H

Medicines.org.uk. 2021. Coversyl arginine plus 5 mg/1.25 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 5 August 2021].

https://www.medicines.org.uk/emc/product/6223/smpc>

Dailymed.nlm.nih.gov. 2021. DailyMed - PERINDOPRIL ERBUMINE tablet. [online] Available at: < [Accessed 4 August 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fcaefca9-e6ca-4c97-9eb8-7f1c619ce4d0>

Drugs, H., 2021. Perindopril: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 4 August 2021].

https://medlineplus.gov/druginfo/meds/a602017.html>

Medicines.org.uk. 2021. Perindopril Erbumine 4 mg tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 4 August 2021].

https://www.medicines.org.uk/emc/product/4390/smpc#gref>

Dailymed.nlm.nih.gov. 2021. DailyMed - INDAPAMIDE tablet. [online] Available at: < [Accessed 5 August 2021].

https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=788ebfde-39a2-42a4-9bd6-34ad87f66a97>
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Information on this page was last updated on 2 Nov 2021

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