Conivaptan

Description

Conivaptan is used for the treatment of decreased sodium levels in hospitalized patients with euvolemic and hypervolemic hyponatremia. This medicine is not recommended for use in patients aged less than 18 years.

Side effects

Major & minor side effects for Conivaptan

  • Blurred vision
  • Discoloration of the skin
  • Decreased urine output
  • Dizziness
  • Dry mouth
  • Headache
  • Irregular heart beat
  • Muscle pain
  • Nausea or Vomiting
  • Rapid weight gain
  • Unusual tiredness or weakness
  • Stomach pain
  • Increased thirst
  • Cough
  • Drowsiness
  • Tingling of hands or feet

Uses of Conivaptan

What is it prescribed for?

  • Hyponatremia
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were not reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue the medicine or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to conivaptan or any other inactive ingredients present along with it.

Hypovolemic Hyponatremia

This medicine is not recommended for use in patients suffering from hypovolemic hyponatremia due to the increased risk of worsening of the patient's condition.

Anuria

This medicine is not recommended for use in patients suffering from anuria (inability to produce urine) due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment due to the risk of severe adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue the medicine or to discontinue breastfeeding based on your clinical condition.
General warnings

Osmotic demyelination syndrome

This medicine may lead to a condition called Osmotic demyelination syndrome (severe damage of the layer covering the nerve cells) on overly rapid correction of serum sodium levels. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypovolemia or Hypotension

This medicine should be used with caution due to the increased risk of hypovolemia (reduced blood volume) or hypotension (low blood pressure). Close monitoring of clinical condition and electrolyte status, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

Use in Children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Atazanavir

Alfuzosin

Cisapride

Ketoconazole

Disease interactions

Liver impairment

This medicine should be used with caution in patients suffering from liver impairment due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Impaired kidney function

This medicine should be used with caution in patients suffering from kidney impairment due to the increased risk of adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients suffering from severe renal impairment.

Congestive heart failure

This medicine should be used with extreme caution in patients with hypervolemic hyponatremia associated with heart failure due to the increased risk of adverse effects. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine blocks the passage of excess sodium through the urine, thus increasing the sodium level in the body.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Vasopressin antagonists, Electrolyte Modifiers

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 20 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021697lbl.pdf

Conivaptan [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 20 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Conivaptan

DailyMed - Vaprisol Dextrose in Plastic Container- conivaptan hydrochloride injection, solution [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 20 December 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5150d9d9-01dc-4a52-9858-214c66d8caea

Conivaptan - DrugBank [Internet]. Drugbank.ca. 2018 [cited 21 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00872

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Information on this page was last updated on 8 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.