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Concor Plus Tablet
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Concor Plus Tablet

Manufactured byMERCK INDIA LTD
ContainsBisoprolol (5 mg) + Hydrochlorothiazide (12.5 mg)
Description
Concor Plus Tablet is a combination medicine used for the treatment of a mild to moderate hypertension. Frequent monitoring of blood pressure and electrolytes levels is necessary during treatment with this medicine. Patients are advised to follow a strict exercise and diet regimen along with this medicine to get the best possible effect.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Concor Plus Tablet

  • Diarrhea
  • Joint pain
  • Heartburn
  • Sleepiness
  • Stomach discomfort
  • Runny Nose
  • Chest pain
  • Shortness of breath
  • Unusual tiredness or weakness
  • Decreased sexual urge
  • Rapid weight gain

Uses of Concor Plus Tablet

What is it prescribed for?

  • Mild to moderate hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed in 2 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 12 to 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to Bisoprolol, other beta-blockers, hydrochlorothiazide, other sulfonamides, or any other inactive ingredients present in the formulation.

Cardiogenic shock

This medicine is not recommended for use in the patients suffering from cardiogenic shock due to the increased risk of worsening the patient's condition.

Heart block greater than first degree

This medicine is not recommended for use in patients having a heart block greater than first degree due to the increased risk of worsening the patient's condition.

Sinus Bradycardia

This medicine is not recommended for use in patients suffering from sinus bradycardia due to the increased risk of worsening the patient's condition.

Anuria

This medicine is not recommended for use in patients with a condition called anuria (a condition where the kidney is unable to produce urine) due to the increased risk of worsening the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Major surgery

This medicine should be used with extreme caution in patients undergoing a major surgery due to the increased risk of severe adverse effects. Close monitoring of heart function is recommended for such patients.

Lung Disease

This medicine should be used with caution in the patients with lung disease who do not respond to other antihypertensives. Start with the lowest possible dose and increase the dose based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with diabetes. It may mask the hypoglycemic symptoms. Regular monitoring of blood glucose levels is necessary. An alternate medicine should be considered based on the clinical condition.

Sports

Athletes are advised not to indulge in certain sports while using this medicine. Archery, racing, shooting and other high-risk sports should be avoided. Sportspersons should refer to the list of medicines published by World Anti-Doping Agency (WADA) which are not to be taken while participating in specific sports events.

Hyperthyroidism

This medicine should be administered with caution in patients with increased thyroid levels. Abrupt withdrawal of this medicine may lead to a life-threatening condition called thyroid-storm. Frequent monitoring of thyroid levels is necessary. An alternative treatment option should be considered in some cases based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patients suffering from liver diseases due to an increase in the risk of serious adverse effects including coma. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Volume and electrolyte depletion

Use of this medicine may alter the blood volume levels and electrolyte levels. This may cause dizziness, dry mouth, and acid-base imbalance. Close monitoring of blood pressure and electrolyte levels is necessary while taking this medicine. Report any symptoms such as weakness, lethargy, muscle pain, drowsiness, dizziness, irregular heartbeat, etc. to the doctor immediately.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Regular monitoring of kidney function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Alprazolam

Insulin

Theophylline

Antidepressants

Nonsteroidal anti-inflammatory medicines

Diltiazem

Disease interactions

Asthma

This medicine is not recommended for use in patients with bronchial asthma or chronic obstructive pulmonary disease since it may worsen the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Glaucoma

This medicine should be administered with caution in patients suffering from glaucoma. A change in the dose of the current glaucoma medicine may be required in some cases. Replacement with a suitable alternative may be necessary based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with a known history of diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with hyperuricemia since this medicine decreases the uric acid excretion and results in serious side effects. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.
Food interactions
Coadministration of multivitamin with minerals and this combination medicine should be avoided since it may decrease the effects of the medicine. A time gap of at least 2 hours should be maintained between the administration of multivitamin with minerals and this combination medicine to avoid their interaction.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Bisoprolol relaxes the blood vessels and reduces the heart rate, promoting a smooth flow of blood. Hydrochlorothiazide increases the excretion of water and sodium through the urine. Their combination is thus effective in reducing the blood pressure.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Beta blockers with thiazides, Antihypertensive combinations

Schedule

Schedule H

DailyMed - BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE - bisoprolol fumarate and hydrochlorothiazide tablet, coated [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 11 January 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ec524b62-3b42-4c36-bca6-7ef442fcd477

[Internet]. Accessdata.fda.gov. 2019 [cited 11 January 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020186s027s028lbl.pdf

[Internet]. Mri.cts-mrp.eu. 2019 [cited 11 January 2019]. Available from:

https://mri.cts-mrp.eu/Human/Downloads/BE_H_0126_002_FinalPL.pdf

[Internet]. Pharmadynamics.co.za. 2019 [cited 11 January 2019]. Available from:

https://pharmadynamics.co.za/wp-content/uploads/2018/07/Bilocor-Co-PIL-English.pdf
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Information on this page was last updated on 31 May 2019

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