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Combinase AQ Nasal Spray

Manufactured byZydus Cadila
ContainsFluticasone propionate (50 mcg) + Azelastine (140 mcg)
Description
Combinase AQ Nasal Spray is a combination of Fluticasone Propionate and Azelastine. It is used to relieve symptoms associated with allergic rhinitis (an allergic reaction causing sneezing, runny nose, and itchy or watery eyes). Combinase AQ Nasal Spray works by blocking the release of chemical substances that is responsible for allergic reactions. Combinase AQ Nasal Spray shows side effects like dryness and irritation of the nose and throat, headache, fever, nose bleeding, etc. Inform your doctor if these side effects remain for a long time or become severe. Avoid using this medicine if you are allergic to it. Combinase AQ Nasal Spray is a prescription medicine. The dose of medicine and the duration of treatment will be determined by your doctor based on your health condition. Follow all the instructions mentioned on the label or packaging insert for usage. Avoid using more than the prescribed dose or for a longer duration. Combinase AQ Nasal Spray can increase the risk of getting an infection or worsening of the pre-existing infection, as it may weaken your immune system. Hence, maintain proper hygiene and keep a distance from people who are sick or have infections. Inform your doctor if you have liver or eye problems or infections like tuberculosis before using Combinase AQ Nasal Spray. Combinase AQ Nasal Spray is not recommended for use in children below six years of age. Also, inform your doctor if you are pregnant or are breastfeeding before using this medicine.

Side effects

Major & minor side effects for Combinase AQ Nasal Spray

  • Blurred vision
  • Unusual taste
  • Dryness and irritation of the nose and throat
  • Drowsiness or sleepiness
  • Headache
  • Cough
  • Nose bleed

Uses of Combinase AQ Nasal Spray

What is it prescribed for?

  • Allergic Rhinitis
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time taken by Combinase AQ Nasal Spray to show its action is not known.
  • How long do the effects of this medicine last?
    The amount of time for which Combinase AQ Nasal Spray remains active in your body is not known.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported for Combinase AQ Nasal Spray.
  • Can this medicine be taken during pregnancy?
    Combinase AQ Nasal Spray is not recommended for use during pregnancy as it may cause harm to your foetus. Consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Combinase AQ Nasal Spray is not recommended for use while breastfeeding, as it is unknown whether this medicine passes into the breastmilk. If you are breastfeeding, consult your doctor before using this medicine.

Allergy

Avoid using Combinase AQ Nasal Spray if you are allergic to it. Seek immediate medical attention if you experience any symptoms such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Warnings for special population

Pregnancy

Combinase AQ Nasal Spray is not recommended for use during pregnancy as it may cause harm to your foetus. Consult your doctor if you are pregnant.

Breast-feeding

Combinase AQ Nasal Spray is not recommended for use while breastfeeding, as it is unknown whether this medicine passes into the breastmilk. If you are breastfeeding, consult your doctor before using this medicine.
General warnings

Driving or Operating machines

Combinase AQ Nasal Spray may cause symptoms such as blurred vision, drowsiness, sleepiness, etc., in some cases. Hence, avoid driving vehicles or operating machines if you experience such symptoms.

Use in Children

Combinase AQ Nasal Spray is not recommended for use in children less than six years of age as the safety and efficacy data are not clinically established.

Growth retardation

Combinase AQ Nasal Spray may cause growth retardation in some cases when used for a long duration. Your child's doctor may prescribe the minimum effective dose to reduce the chances of such side effects. Monitor the growth of your child during treatment with this medicine.

Nosebleed and nasal ulceration

Combinase AQ Nasal Spray may cause nosebleeds and nasal ulcerations (sores in the nose). Consult your doctor if these symptoms persist or worsen.

Impaired wound healing

Combinase AQ Nasal Spray is not recommended for use if you have recently undergone nasal surgery or have a nasal injury that is not completely healed. This medicine may delay healing and worsen your condition.

Candida infection

Combinase AQ Nasal Spray should be used with caution as it may cause fungal infection of the nose and pharynx if it is used for a prolonged period. Consult your doctor if you experience any symptoms of infection.

Missed Dose

Try not to skip any dose of Combinase AQ Nasal Spray. Use the missed dose as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Never use more doses than prescribed. If you suspect an overdose of Combinase AQ Nasal Spray, consult your doctor for further guidance.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Carbamazepine

Clarithromycin

Ketoconazole

Disease interactions

Hyperadrenocorticism

Hyperadrenocorticism is a condition that occurs due to high levels of cortisol (a chemical substance that helps your body respond to stress, regulate blood sugar, and fight infections) in the body. High doses of Combinase AQ Nasal Spray should be used with caution as it may cause or worsen hyperadrenocorticism, in rare cases.

Infections

Combinase AQ Nasal Spray should be used with extreme caution if you have tuberculosis (a lung infection) or other active infections. This medicine can suppress your immune activity and worsen your condition, especially if you are using high doses of this medicine.

Ocular herpes infection

Ocular herpes simplex is an eye infection caused by the herpes simplex virus. Combinase AQ Nasal Spray should be used with caution if you have an ocular herpes infection. This medicine can damage the cornea (transparent front part of the eye) and may worsen your condition.

Eye problems

Prolonged use of high doses of Combinase AQ Nasal Spray may cause cataracts (a hazy layer that forms in the lens of the eye) or increased fluid pressure inside the eye. Hence it should be used with caution if you have a history of cataracts or glaucoma (an eye condition with abnormally high pressure inside the eye that may lead to vision loss).

Osteoporosis

Osteoporosis is a condition in which your bones become weak and brittle.Combinase AQ Nasal Spray should be used with caution if you have osteoporosis. Prolonged use of this medicine may cause loss of bone density and may further worsen your existing condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Combinase AQ Nasal Spray is used in the treatment of allergic rhinitis. Use this medicine as advised by your doctor. Do not use more or less than the prescribed dose. Avoid the discontinuation of this medicine without consulting your doctor, as it may worsen your symptoms. Consult the doctor if you experience any undesirable effects that persist or worsen. Avoid driving vehicles or operating machines after using this medicine as it may cause blurred vision, dizziness, etc. Inform your doctor about all your current medications and other health conditions before starting the treatment with Combinase AQ Nasal Spray. Keep away from the reach of children and pets. Ensure that the unused medicine is disposed of properly.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Combinase AQ Nasal Spray works by blocking the release of chemical substances that causes allergic reactions. Thus it helps in relieving allergic symptoms such as sneezing, runny nose, itchy or watery eyes, etc.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Nasal antihistamines and decongestants, Nasal steroids

Schedule

Schedule H

CiplaMed. 2021. DUONASE Nasal Spray. [online] Available at: < [Accessed 25 October 2021].

https://ciplamed.com/content/duonase-nasal-spray>

Dailymed.nlm.nih.gov. 2021. Ticalast Nasal Spray Kit(azelastine hydrochloride and fluticasone propionate, saline nasal wash) These highlights do not include all the information needed to use DYMISTA safely and effectively. See full prescribing information for DYMISTA. DYMISTA (azelastine hydrochloride and fluticasone propionate) nasal spray, for intranasal use Initial U.S. Approval: 2012. [online] Available at: < [Accessed 25 October 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=45d828ce-b1a3-4252-93d8-a150b67b9e99>

Pubchem.ncbi.nlm.nih.gov. 2021. Fluticasone propionate. [online] Available at: < [Accessed 25 October 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Fluticasone-propionate>

Pubchem.ncbi.nlm.nih.gov. 2021. Azelastine. [online] Available at: < [Accessed 25 October 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/2267>

Zuventus.co.in. 2021. Zuventus Healthcare. [online] Available at: < [Accessed 25 October 2021].

http://www.zuventus.co.in/patient_wise_products_selected.aspx?Medi_Id=147>
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Information on this page was last updated on 4 Feb 2022

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