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Coliwin-R Capsule

Manufactured byMANKIND PHARMACEUTICALS LTD
ContainsChlordiazepoxide (5 mg) + Clidinium (2.5 mg) + Dicyclomine (10 mg) + Rabeprazole (10 mg)
Description

Coliwin-R Capsule is a combination medicine which may be used to relieve cramps and abdominal pain associated with the gastrointestinal (the stomach and intestines) disorders such as irritable bowel syndrome, diverticulitis, enterocolitis, etc. when these digestive function disorders are associated with excessive tension and anxiety. It is also used to treat peptic ulcer disease characterized by abdominal pain, burning stomach pain, nausea, feeling fullness, bloating, etc.

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Side effects

Major & minor side effects for Coliwin-R Capsule

  • Blurred vision
  • Constipation
  • Dry mouth
  • Urinary hesitancy
  • Dry mouth
  • Nervousness
  • Skin rash
  • Loss of appetite
  • Shakiness in the legs, arms, hands, or feet
  • Restlessness

Uses of Coliwin-R Capsule

What is it prescribed for?

  • Irritable bowel syndrome
  • Muscle spasm of gastrointestinal tract
  • Peptic Ulcer
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as confusion, dizziness, nausea, vomiting, weakness, fainting, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on the clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to clidinium, dicyclomine, chlordiazepoxide, rabeprazole, or any other inactive ingredients present along with the formulation.

Glaucoma

This medicine is not recommended for use in patients suffering from glaucoma since it may worsen the patient's condition.

Bengin prostatic hyperplasia

This medicine is not recommended for use in patients suffering from enlargement of the prostate gland condition, since it may worsen the patient's condition.

Severe respiratory insufficiency

This medicine is not recommended for use in patients suffering from severe respiratory insufficiency since it may worsen the patient's condition.

Obstructive conditions

This medicine is not recommended for use in patients suffering from conditions like obstructive uropathy and obstructive gastrointestinal diseases due to the increased risk of worsening the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on the clinical condition.
General warnings

Impaired kidney function

This medicine should be used with extreme caution in patients with kidney diseases due to the increased risk of serious adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Liver Disease

This medicine should be used with extreme caution in patients with liver function impairment or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Report any symptoms such as nausea, fever, rashes, dark urine, etc. to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in children

This medicine is not recommended for use in patients below 18 years of age unless directed by the doctor.

Seizures

This medicine should be used with extreme caution in patients suffering from seizure disorder due to the increased risk of recurrent seizures. Report any unusual symptoms to the doctor immediately. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Driving or operating machinery

Use of this medicine may cause symptoms such as dizziness, blurred vision, confusion, drowsiness, etc. in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Withdrawal symptoms

Abrupt discontinuation of this medicine may increase the risk of adverse effects, especially if you have been using a high dose for a long duration. A gradual dose reduction is recommended to avoid these reactions. Do not stop the use of this medicine without consulting your doctor.

Other medicines

Since this medicine may interact with other medicines and cause severe adverse effects, you are advised to report all your current medicines, including any herbs and supplements, to the doctor before beginning treatment with this medicine.

Lupus erythematosus

This medicine should be used with caution due to the increased risk of systemic and cutaneous lupus erythematosus. Report any symptoms such as extreme tiredness, painful joints, rashes and lesions on the skin, etc. to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Clostridium Difficile-associated diarrhea

This medicine may increase the risk of Clostridium difficile-associated diarrhea. This diagnosis should be considered if the patient's diarrhea does not improve. Appropriate corrective measures or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as confusion, dizziness, nausea, vomiting, weakness, fainting, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
Interaction with Medicine

Opioids

Antihypertensives

Ipratropium

Amitriptyline

Topiramate

Zonisamide

Potassium Citrate

Disease interactions

Gastrointestinal obstruction

This medicine is not recommended for use in patients with gastrointestinal obstruction diseases such as paralytic ileus, stenosing peptic ulcer, pyloric obstruction, esophageal stricture or stenosis, etc. due to the risk of worsening of the patient's condition. An alternative treatment option should be considered based on the clinical condition.

Glaucoma

This medicine is not recommended for use in patients with glaucoma due to the risk of worsening of the patient's condition. An alternative treatment option should be considered based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patients with liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Arrhythmias

This medicine should be used with extreme caution in patients suffering from irregular heartbeats due to the increased risk of worsening of the patient's condition. Close monitoring of heart function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Tardive Dyskinesia

This medicine should be used with extreme caution in patients with a history of Tardive Dyskinesia due to the increased risk of recurrent symptoms. Report any symptoms such as uncontrolled movements of the tongue, mouth, lips, jaw, hands, feet, etc. to your doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Infectious Diarrhea

This medicine is not recommended for use in patients with infectious diarrhea due to the risk of worsening of the patient's condition. An alternative treatment option should be considered based on the clinical condition.

Hypertension

This medicine should be used with caution in patients with high blood pressure due to the risk of worsening of the patient's condition. Close monitoring of blood pressure is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Seizure disorders

This medicine should be used with extreme caution in patients suffering from seizure disorder due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Depression

This medicine should be used with extreme caution in patients with a history of depression or other psychiatric disorders due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Renal Dysfunction

This medicine should be used with extreme caution in patients with kidney diseases due to the increased risk of serious adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Osteoporosis

This medicine should be used with extreme caution in patients with osteoporosis due to the increased risk of osteoporosis-related fractures. Established treatment guidelines should be followed strictly in such patients. Replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

Causes sleepiness

How it works
Chlordiazepoxide works by stabilizing the brain cells and thus reduces the excitability of the brain cells. Clidinium relaxes the smooth muscles of the stomach and intestines and relieves muscle spasms and cramps. Dicyclomine works by blocking the action of a chemical substance in the body and relieves the symptoms like the stomach and intestinal cramping. Rabeprazole reduces the production of acid in the stomach.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Anxiolytic and Anticholinergic agents, Anticholinergics/antispasmodics, Proton pump inhibitors

Schedule

Schedule H

Dicyclomine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 10 July 2017]. Available from:

https://www.drugbank.ca/drugs/DB00804

DailyMed - Dicyclomine hydrochloride capsule - dicyclomine hydrochloride tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 10 July 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ac145b81-5f26-4914-b47f-6c4958e94146

DailyMed - Chlordiazepoxide hydrochloride capsule [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 1 June 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=68c7d8a7-08b3-4a1a-acbd-09bbe67b8d4a

Clidinium - DrugBank [Internet]. Drugbank.ca. 2018 [cited 20 November 2018]. Available from:

https://www.drugbank.ca/drugs/DB00771

Rabeprazole - DrugBank [Internet]. Drugbank.ca. 2019 [cited 17 September 2019]. Available from:

https://www.drugbank.ca/drugs/DB01129
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Information on this page was last updated on 17 Sep 2019

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