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Cobate-GM Skin Cream
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Cobate-GM Skin Cream

Manufactured bySUPER FORMULATIONS PVT LTD
ContainsClobetasol (0.05 %w/w) + Gentamicin (0.1 %w/w) + Miconazole (2 %w/w) + Clotrimazole (1 %w/w)
Description
Cobate-GM Skin Cream is a combination medicine which is used for the treatment of mixed secondary infections in dermatoses. It helps in the treatment of steroid responsive dermatoses associated with superficial bacterial and fungal infections of the skin.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Cobate-GM Skin Cream

  • Skin rash
  • Redness of skin
  • Blisters under the skin
  • Burning or tingling sensation of skin
  • Itchy and dry skin
  • Easy bruising of skin
  • Unusually warm skin
  • Lightening of skin at the area of application

Uses of Cobate-GM Skin Cream

What is it prescribed for?

  • Mixed secondary infections in dermatoses
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to clobetasol, miconazole, gentamicin, clotrimazole or any other inactive ingredients present along with the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
General warnings

Resistance

This medicine should be used for the complete prescribed course even when the symptoms get better. The infection may recur and the fungi may get less sensitive to the medicine, resulting in drug resistance, if it is not used for the complete prescribed course.

Cushing's syndrome

This medicine may cause hypothalamic-pituitary-adrenal (HPA) axis suppression and Cushing's syndrome in patients receiving high doses for a prolonged period. Any symptoms of swelling of the face, increase in the blood glucose levels, etc. should be informed to the doctor on priority. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

External use

This medicine is only recommended for external use. Avoid contact with the mouth, eyes, mucous membranes, cuts, grazes, or wounds.

Use only in confirmed infection

This medicine should not be used until the infection is diagnosed by a doctor. Other diseases may also show similar symptoms.

Other medicines

This medicine may interact with a large number of medications and may cause severe adverse effects. Hence, it is advised that you report the use of all your medicines including any herbs and supplements to the doctor before beginning therapy with this medicine.

Allergic reactions

This medicine has the potential of causing moderate to severe allergic reactions in the body. Any instance indicative of allergic reactions should be reported to the doctor in the first instance.

Missed Dose

Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not apply a double dose to make up for the missed dose.

Overdose

An overdose of this medicine is not likely to cause severe symptoms. However, ingestion of this medicine may cause harm and immediate medical intervention may be required.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Antidiabetic medicines

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Apply a thin layer of the cream to the affected area as instructed by the doctor. Follow all the usage instructions mentioned on the label or the package insert. Do not apply in larger or smaller quantities than recommended. Do not cover the application area with bandages or other coverings unless specifically instructed by the doctor. Contact your doctor if symptoms do not improve or resolve after one week of use.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Clobetasol works by inhibiting the release of certain substances in the body that cause inflammation (swelling, redness, pain, etc). Gentamicin works by inhibiting the protein synthesis which is essential for the bacteria to grow. Miconazole acts by stopping the production of a certain vital component for the fungi. This results in disruption of the cell membrane formation process and inhibits the growth of the organism. Clotrimazole stops the growth of fungi by disrupting certain vital processes in the cell.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Topical steroids with anti-infectives, Topical antifungals

Schedule

Schedule H

Clobetasol - DrugBank [Internet]. Drugbank.ca. 2019 [cited 9 May 2019]. Available from:

https://www.drugbank.ca/drugs/DB11750

Gentamicin - DrugBank [Internet]. Drugbank.ca. 2019 [cited 9 May 2019]. Available from:

https://www.drugbank.ca/drugs/DB00798

Miconazole - DrugBank [Internet]. Drugbank.ca. 2019 [cited 9 May 2019]. Available from:

https://www.drugbank.ca/drugs/DB01110

Clotrimazole | C22H17ClN2 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 10 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/2812

Clobetasol: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 10 May 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a686008.html
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Information on this page was last updated on 15 Jul 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.