CLIVARINE 1432 IU INJECTION

Manufactured byAbbott India Ltd.
ContainsReviparin
Description

CLIVARINE 1432 IU INJECTION is an anticoagulant used to prevent the formation and growth of blood clots in patients with certain specific medical conditions. It is also used to prevent blood clots that may potentially form during certain complex medical procedures.

Substitutes

List of substitutes for CLIVARINE 1432 IU INJECTION

Side effects

Major & minor side effects for CLIVARINE 1432 IU INJECTION

  • Injection site redness, bruising, or sores
  • Unusual bleeding or bruising
  • Dark red spots in the mouth
  • Nausea or Vomiting
  • Fever with body pain
  • Temporary hair loss
  • Dizziness and lightheadedness
  • Bloody or coffee colored vomit
  • Excessive menstrual bleeding
  • Black or tarry stools
  • Sleep disturbances
  • Increase in the potassium levels
  • Fall in blood pressure
  • Fall in blood platelet levels
  • Internal bleeding and hemorrhage
  • Burning or tingling sensation of skin

Uses of CLIVARINE 1432 IU INJECTION

What is it prescribed for?

  • Venous thromboembolic events
  • Prevention of venous thromboembolic events during surgery
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time taken for this medicine to show its effect is not clinically established.
  • Duration of effect
    The duration of time for which this medicine remains effective in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women since the safety and efficacy of use are not clinically established.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women since the safety and efficacy of use are not clinically established.

Allergy

This medicine is not recommended for use in patients with a known allergy to reviparin or any other inactive ingredient present along with it. Use of this medicine is also not recommended in patients having a known allergy to heparin or pork products.

Active major bleeding

This medicine is not recommended for use in patients with a known heavy active bleeding due to the increased risk of worsening of the patient's condition.

Thrombocytopenia

This medicine is not recommended for use in patients with an abnormally low platelet count due to the increased risk of excessive bleeding.

Patients with prosthetic heart valves

This medicine is not recommended for use in patients having a prosthetic heart valve (both mechanical and tissue valve types).
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women since the safety and efficacy of use are not clinically established.

Breast-feeding

This medicine is not recommended for use in breastfeeding women since the safety and efficacy of use are not clinically established.
General warnings

Hemorrhage and risk factors

Use of this medicine should be initiated only after internal bleeding or hemorrhage and associated risk factors are ruled out. All the underlying causes of bleeding such as peptic ulcer disease, hemophilia, impaired hemostasis, etc. should also be ruled out before the administration of this medicine.

Thrombocytopenia

Use of this medicine may cause low levels of platelets (thrombocytopenia). It is advised to monitor the blood platelet levels at regular intervals while this medicine is administered. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Liver/kidney disease

This medicine should be used with caution in patients having an impairment of normal liver/kidney function. Appropriate dose adjustments and frequent clinical monitoring are recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition.

Other medicines

This medicine may interact with many other medicines and may cause severe side effects. Hence, you are advised to report the use of all medicines including herbs and supplements to the doctor before beginning treatment with this medicine.

Route of administration

This medicine should be administered subcutaneously. Intramuscular route of administration should be avoided.

Use in elderly

This medicine should be used with extreme caution in the elderly patients since the risk of adverse effects is significantly high.

Use in children

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Benzyl alcohol as preservative

Dosage forms containing benzyl alcohol as a preservative should not be administered to neonates, infants, pregnant or breastfeeding women. Benzyl alcohol may cause a fatal adverse event known as Gasping syndrome in neonates and infants.

Missed Dose

This medicine is usually administered in a clinical or hospital setup. However, if you are administering it at home and miss a scheduled dose, then call your doctor immediately for further instructions.

Overdose

Seek emergency medical attention in case of an overdose or suspected overdose. Symptoms may include nosebleed, unusual bruising and bleeding, and the presence of blood in stool or urine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Lisinopril

Propranolol

Telmisartan

Warfarin

Aspirin

Ketorolac

Nitroglycerin

Benazepril

Disease interactions

Hemophilia

This medicine should be administered with extreme caution in patients suffering from hemophilia or other bleeding disorders due to the increased risk of excessive bleeding.

Liver/kidney impairment

This medicine should be used with caution in patients having an impairment of normal liver/kidney function. Appropriate dose adjustments and frequent clinical monitoring are recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition.

Peptic ulcer disease

This medicine should be administered with extreme caution in patients with peptic ulcer disease due to the increased risk of excessive bleeding.

Bacterial endocarditis

This medicine should be used with extreme caution in patients with subacute bacterial endocarditis, characterized by swelling of the heart walls or valves due to a bacterial infection, due to the risk of worsening of the patient's condition.
Food interactions
This medicine should be used with caution with fish oil or other food products containing omega-3 polyunsaturated fatty acids due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.
This medicine should be used with caution with ginger/garlic due to the increased risk of bleeding. Contact your doctor immediately if you experience any unusual bleeding or bruising, dizziness, weakness, and the presence of blood in sputum/urine/stool. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.
Lab interactions
Information not available.
Administer CLIVARINE 1432 IU INJECTION exactly as instructed by the doctor. It should not be injected into the muscles. It is advised to administer this medicine under the supervision of a doctor in a clinical setup with regular monitoring of blood clotting time and other related parameters. Your doctor may ask you to undergo certain tests to determine the safety of use of this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by interfering with the normal clotting process and decreasing the clot forming ability of the blood.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Heparins

Schedule

Schedule H

Gore M e. Reviparin sodium clivarine: a review of its therapeutic use. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 29 August 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/15887830

HK B. Reviparin sodium - a new low molecular weight heparin. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 29 August 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/11829731

Reviparin - DrugBank [Internet]. Drugbank.ca. 2017 [cited 29 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB09259

RG H. Low-molecular-weight heparin (LMWH) in the treatment of thrombosis. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 29 August 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/15210403

Wellington K e. Reviparin: a review of its efficacy in the prevention and treatment of venous thromboembolism. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 29 August 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/11465877

[Internet]. 2017 [cited 4 September 2017]. Available from:

http://www.europeanreview.org/wp/wp-content/uploads/1018.pdf

[Internet]. 2017 [cited 4 September 2017]. Available from:

https://www.sgna.org/Portals/0/Home/JBICSR1213-0002-Reading02.pdf
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