Clarithromycin

Description

Clarithromycin is a bactericidal antibiotic which is used in the treatment of infections caused by the bacteria. It is used with other medications in the treatment of helicobacter pylori infections. It is not recommended in the patients who are allergic to macrolides.

Side effects

Major & minor side effects for Clarithromycin

  • Fever or chills
  • Lower back pain
  • Abdominal pain
  • Nausea or Vomiting
  • Diarrhea
  • Skin Rash
  • Acid or sour stomach
  • Excessive air or gas in stomach
  • Headache
  • Heartburn

Uses of Clarithromycin

What is it prescribed for?

  • Tonsilitis/Pharyngitis
  • Bronchitis
  • Pneumonia
  • Helicobacter pylori Infection
  • Skin and Structure Infection
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed in 2 to 3 hours for an immediate release tablet and 5 to 8 hours for an extended release tablet.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 9 to 21 hours for an Immediate release.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for breastfeeding women unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine. Monitoring of undesired effects like diarrhea, candidiasis (thrush, diaper rash) is necessary.

Allergy

Avoid taking this medicine if you have a known allergy to it or any other macrolides.

Impaired Liver function

Clarithromycin is not recommended in the patients with the history of any liver injury.
Warnings for special population

Pregnancy

This medicine is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine.

Breast-feeding

This medicine is not recommended for breastfeeding women unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine. Monitoring of undesired effects like diarrhea, candidiasis (thrush, diaper rash) is necessary.
General warnings

Impaired liver function

Clarithromycin is not recommended in the patients with the history of liver injury. Any signs and symptoms of liver injury like elevated liver enzymes and yellow colored eyes and skin should be reported to the doctor. Discontinue the medicine if the symptoms persist.

QT prolongation

Clarithromycin should be used with caution in the patients receiving QT prolongation medications as it can increase the risk of arrhythmia. Frequent monitoring of heart function is necessary and an alternate medicine should be considered.

Drug-resistance

Usage of Clarithromycin without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that is drug resistant.

Allergy

Avoid taking this medicine if you have a known allergy to Clarithromycin or other macrolides. Seek immediate medical attention if the patient experiences any allergic symptoms like rashes, itching, nausea, vomiting, swelling of lips, hands, and feet.

Impaired kidney function

Clarithromycin should be used with caution in the patients with kidney injury. Half of the recommended dose should be administered if the CrCl is less than 30 ml/min.

Missed Dose

The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for your next dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clonazepam

Amiodarone

Ethinyl Estradiol

Atorvastatin

Disease interactions

QT Prolongation

Inform your doctor if you have arrhythmia, any heart disease or drugs that prolong QT interval such as psychiatric drugs and anti-arrhythmic drugs.

Colitis

Avoid taking Clarithromycin if you experience severe diarrhea, abdominal pain, and blood in stools after taking the medicine. Inform the doctor if you have any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Clarithromycin with or without food. The long-acting tablet should be taken with food. Do not take in larger amounts than advised. Consult the doctor if you experience any undesirable effects. Do not stop taking Clarithromycin before completion of course.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Clarithromycin works by stopping the growth of the bacteria by interfering with the bacterial protein synthesis.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Macrolides

Schedule

Schedule H

[Internet]. 2017 [cited 9 April 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/30852

Clarithromycin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 9 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a692005.html

[Internet]. Dailymed.nlm.nih.gov. 2017 [cited 9 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8a56f36f-4e45-43f6-842b-5c2d319aaaec#section-8.1

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 9 April 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 9 April 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~50E9qW:1

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Information on this page was last updated on 16 Nov 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.