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Clamp (875/125 mg) Tablet

Manufactured byDr. Reddys Laboratories Ltd.
ContainsAmoxycillin (875 mg) + Clavulanic Acid (125 mg)
Description
Clamp (875/125 mg) Tablet is a combination medicine consists of Amoxycillin and Clavulanic acid. Clamp (875/125 mg) Tablet is used to treat bacterial infections of the lungs and airways, middle ear, sinuses, skin, and urinary tract. Amoxycillin interferes with the growth and division process of the bacterial cell wall while clavulanic acid enhances the activity of Amoxycillin in treating infections caused by susceptible bacteria. The common side effects of Clamp (875/125 mg) Tablet are nausea, vomiting, stomach pain, and skin rash. Usually, these side effects are self-limiting. Consult your doctor at the earliest if any of these effects persist for a long time or worsen. Inform your doctor if you are allergic to this medicine or any other antibiotics. You can take Clamp (875/125 mg) Tablet with food as it improves absorption and decreases the risks of stomach upset. Your doctor will decide the dose and frequency based on the severity of the infection. Stick to the dose, time, and way prescribed. Also, ensure to complete the course of treatment even if you feel better after taking few doses of this medicine. Stopping the use of this medicine early may make the infection come back and harder to treat. Avoid taking Clamp (875/125 mg) Tablet if you are having conditions like cholestasis (normal flow of bile from the liver is interrupted) and other liver diseases. This medicine may cause dizziness and sleepiness. Avoid driving or operating a machine if you feel dizzy or sleepy. Clamp (875/125 mg) Tablet can make birth control pills less effective. You may be advised to follow different way of birth control methods to prevent unintended pregnancy. To make sure Clamp (875/125 mg) Tablet is safe for you, share your entire medical history with the doctor, including any previous episode of allergy, heart problem, a blood disorder, lung problem, stomach or intestinal problem, skin disorder, liver or kidney disease. This information is critical as it can help your doctor in planning an overall treatment for you. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding.

Side effects

Major & minor side effects for Clamp (875/125 mg) Tablet

  • Allergic Skin Reaction
  • Diarrhoea
  • Joint pain
  • Skin yellowing
  • Easy bruising and bleeding
  • Heavy menstrual bleeding
  • Tooth discoloration
  • Nausea or vomiting
  • Altered sense of taste
  • Dizziness
  • Painful intercourse
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Black or tarry stools
  • Muscle or joint pain
  • Sleeplessness
  • Irregular heartbeat

Uses of Clamp (875/125 mg) Tablet

What is it prescribed for?

  • Ear infection
  • Sinusitis
  • Pharyngitis/Tonsilitis
  • Lower respiratory tract infection
  • Skin infections
  • Urinary tract infection
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of Clamp (875/125 mg) Tablet can be observed within 1-2 hours after taking it.
  • How long do the effects of this medicine last?
    The effect of Clamp (875/125 mg) Tablet lasts for an average duration of 6-8 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    Clamp (875/125 mg) Tablet has no habit forming tendency.
  • Can this medicine be taken during pregnancy?
    Clamp (875/125 mg) Tablet should be used in pregnant women only if clearly needed. Your doctor may prescribe this medicine if the benefits outweigh the risks.
  • Can this medicine be taken while breast-feeding?
    Clamp (875/125 mg) Tablet pass into the breastmilk in low levels that are not expected to cause any harmful effects in infants. However, consult your doctor before taking this medicine.

Allergy

Avoid taking Clamp (875/125 mg) Tablet if you are previously allergic to it. Seek immediate medical attention if you notice any symptoms like skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.

Cholestasis

Avoid taking Clamp (875/125 mg) Tablet if you are having a condition where the normal flow of bile from the liver is interrupted (cholestasis).

Liver dysfunction

Avoid taking Clamp (875/125 mg) Tablet if you have a history of liver disease associated with the use of this medicine or any other antibiotics.
Warnings for special population

Pregnancy

Clamp (875/125 mg) Tablet should be used in pregnant women only if clearly needed. Your doctor may prescribe this medicine if the benefits outweigh the risks.

Breast-feeding

Clamp (875/125 mg) Tablet pass into the breastmilk in low levels that are not expected to cause any harmful effects in infants. However, consult your doctor before taking this medicine.
General warnings

Allergic reaction

Clamp (875/125 mg) Tablet is likely to cause moderate to a severe allergic reaction and the likelihood is very high in patients who are known to have an antibiotic allergy. Report to the doctor on priority if you notice any allergic reactions.

Diarrhoea

Clamp (875/125 mg) Tablet can cause diarrhoea because it may also kill the helpful bacteria in your stomach or intestine. Get emergency medical help if you experience severe diarrhoea that is watery or bloody.

Antibiotic-resistance

Usage of Clamp (875/125 mg) Tablet without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of the development of bacteria that are antibiotic-resistant.

Liver disease

Regular monitoring of the liver enzyme levels is necessary while taking Clamp (875/125 mg) Tablet and even after completing treatment with this medicine.

Dosing consideration

Clamp (875/125 mg) Tablet is normally given when the infection is very severe and lower dose strengths are proving to be ineffective.

Use in children

Clamp (875/125 mg) Tablet should not be used in children. In children elder than 12 weeks of age or weighing more than 40 kg, suspension forms of this combination are used.

Driving and operating machine

Clamp (875/125 mg) Tablet may cause dizziness and sleepiness in some patients. Avoid driving or operate a machine if you feel dizzy or sleepy.

Missed Dose

If you forget Clamp (875/125 mg) Tablet dose, make sure that you remember to take your next dose on time. Do not take two doses together to make up for a forgotten dose.

Overdose

Never take Clamp (875/125 mg) Tablet more than the prescribed dose. If you suspect that you might have taken an overdose of this medicine, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Doxycycline

Methotrexate

Warfarin

Ethinyl Estradiol

Live vaccines

Disease interactions

Mononucleosis

People with mononucleosis (kissing disease- transmitted by saliva) may develop a maculopapular skin rash after 5-10 days of treatment with this medicine and resolves within days of discontinuing the use. Clamp (875/125 mg) Tablet may not be appropriate medicine in patients with mononucleosis.

Colitis

Clamp (875/125 mg) Tablet can kill the helpful bacteria in your stomach or intestine and leads to diarrhoea. Therefore, use this medicine with extreme caution if you have colitis (swelling of the colon's inner lining).

Kidney diseases

Patients with kidney diseases need special consideration while taking Clamp (875/125 mg) Tablet due to the risk of kidney damage. Dose adjustment should be done based on the clinical condition.
Food interactions
Information not available.
Lab interactions

Urine Sugar Test (Benedict's of Fehling's reagent)

Report the use of Clamp (875/125 mg) Tablet prior to the test. This medicine may give a false-positive result for the presence of glucose/sugar in the urine. The urine sugar test should be performed with a different reagent in case you are receiving this medicine.
Take Clamp (875/125 mg) Tablet with food to avoid stomach upset. Finish the prescribed course of Clamp (875/125 mg) Tablet even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Diarrhoea may occur as a side effect. Taking probiotics along with Clamp (875/125 mg) Tablet may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps. Stop taking Clamp (875/125 mg) Tablet and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it. Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic. Do not crush, break or chew the tablet in the mouth. Consume the tablet immediately after peeling it from the strip. Keep the medicine away from the reach of children and pets.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Clamp (875/125 mg) Tablet is a combination of Amoxycillin and Clavulanic acid. Amoxycillin binds to certain specific receptors and prevents the formation of a necessary component for the cell wall building process. Clavulanic acid is effective against a specific species of bacteria that are resistant to other antibiotic medicines. Thus, the combination becomes effective against an extended range of bacteria.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Beta-lactamase inhibitors, Aminopenicillins

Schedule

Schedule H

Drugs, H., 2021. Amoxicillin and Clavulanic Acid: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 20 May 2021].

https://medlineplus.gov/druginfo/meds/a685024.html>

Dailymed.nlm.nih.gov. 2021. DailyMed - AMOXICILLAN AND CLAVULANATE POTASSIUM tablet, film coated. [online] Available at: < [Accessed 20 May 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=909c85de-c076-4444-b63c-cd8bdc556f36>

Pubchem.ncbi.nlm.nih.gov. 2021. Clavulanic acid. [online] Available at: < [Accessed 20 May 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Clavulanic-acid>

Pubchem.ncbi.nlm.nih.gov. 2021. Amoxicillin. [online] Available at: < [Accessed 22 January 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Amoxicillin>
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Information on this page was last updated on 13 Aug 2021

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