Cincofen (325/400 mg) Tablet

Manufactured byKaptab Pharmaceuticals
ContainsParacetamol (325 mg) + Ibuprofen (400 mg)
Description

Cincofen (325/400 mg) Tablet is a combination medicine used to relieve pain associated with menstrual cycles and arthritis. It is used to relieve mild to moderate pain associated with a headache, toothache, muscle pain, or back pain. It is also used to temporarily relieve fever. This medicine should be used with caution due to the increased risk of liver damage and bleeding complications.

Substitutes

List of substitutes for Cincofen (325/400 mg) Tablet

Side effects

Major & minor side effects for Cincofen (325/400 mg) Tablet

  • Nausea or Vomiting
  • Rash
  • Gastric / Mouth Ulcer
  • Bloody and cloudy urine
  • Abnormal blood counts
  • Fatigue
  • Heartburn
  • Abdominal discomfort
  • Constipation
  • Decreased urine output
  • Yellow colored eyes or skin
  • Ringing or buzzing in the ears
  • Loss of appetite
  • Drowsiness
  • Vomiting of blood

Uses of Cincofen (325/400 mg) Tablet

What is it prescribed for?

  • Fever and Pain
  • Mild to Moderate pain
  • Menstrual Cramps
  • Osteoarthritis
  • Rheumatoid Arthritis
  • Gout
Read More
Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 30 minutes of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 6 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, nausea, joint pain, fever, etc.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to paracetamol, ibuprofen, or any other NSAIDs.

Analgesic Nephropathy (Kidney Disease)

This medicine is not recommended for use in patients suffering from an impaired kidney function associated with excessive use of painkillers.

Severe liver impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of serious adverse effects.

Asthma

This medicine is not recommended for use in patients with a known history of NSAID-induced asthma due to the increased risk of worsening of the patient's condition.

Coronary Artery Bypass Surgery (CABG)

This medicine is not recommended for use in patients with a recent heart surgery due to the increased risk of severe adverse reactions.

Peptic Ulcer

This medicine is not recommended for use in patients with peptic ulcer disease or any gastrointestinal bleeding disorders due to the increased risk of worsening of the patient's condition.

Pediatric patients

This medicine is not recommended for use in children.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Chronic Malnutrition

This medicine should be used with extreme caution in patients suffering from malnourishment due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Gastro-intestinal bleeding

This medicine may cause severe gastrointestinal bleeding and perforation after prolonged usage. These adverse events may occur with or without warning symptoms. This risk is especially higher in the elderly population and in patients with a history of gastrointestinal diseases. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Chronic alcoholics

This medicine is not recommended for use in chronic alcoholic patients due to the increased risk of severe liver damage.

Anemia

This medicine should be used with caution in patients with anemia due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Liver impairment

This medicine should be used with extreme caution in patients suffering from liver function impairment or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

If a dose of this medicine is missed, take the dose as soon as you remember it. If it is almost time for the next dose, skip the missed dose and take the next dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, nausea, joint pain, fever, etc.
Interaction with Medicine

Carbamazepine

Methotrexate

Phenytoin

Sodium Nitrite

Leflunomide

Prilocaine

Corticosteroids

Aspirin

Antihypertensives

Anticoagulants

Disease interactions

Fluid Retention and edema

This medicine may cause fluid retention and edema in some patients. Close monitoring of blood pressure, electrolyte levels, and heart function may be required based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases.

Skin rash

This medicine may cause fatal skin allergies without any warnings in some patients. Signs and symptoms such as rashes, hives, fever, or other allergic symptoms should be reported to the doctor without any delay. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions

5-HIAA Urine Test

You may get a false-positive result for this test while taking this medicine. It is advised that you inform the doctor and lab technician about all your current medicines including herbs and supplements before undergoing any lab tests.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. This medicine should be taken with food or immediately after food. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine acts on the brain centers responsible for regulating the body temperature to reduce elevated temperatures. It also inhibits the synthesis and release of certain natural substances responsible for causing pain and swelling.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Miscellaneous analgesics, Nonsteroidal anti-inflammatory agents, Analgesic antipyretic combinations

Schedule

Schedule H

[Internet]. 2017 [cited 14 September 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/18127

[Internet]. 2017 [cited 14 September 2017]. Available from:

https://davisplus.fadavis.com/3976/meddeck/pdf/acetaminophen.pdf

[Internet]. 2017 [cited 14 September 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/20509

Ibuprofen: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 14 September 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682159.html

[Internet]. 2017 [cited 22 September 2017]. Available from:

http://www.medipharlabs.com/attachments/article/110/MAXIFEN.pdf
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