Cilastatin

Description

Cilastatin is a dehydropeptidase inhibitor that is used in a combination with imipenem to increase its effectiveness. This combination is used in treating infections such as lower respiratory tract infections, urinary tract infections, intraabdominal infections, bacterial septicemia, etc. caused by various types of bacteria.

Side effects

Major & minor side effects for Cilastatin

  • Nausea
  • Vomiting
  • Rash
  • Hives
  • Itching of skin

Uses of Cilastatin

What is it prescribed for?

  • Lower Respiratory Tract Infection
  • Urinary Tract Infection
  • Intra-abdominal Infection
  • Bacterial Septicemia
  • Bone and Joint infections
  • Endocarditis
  • Skin and Skin Structure Infection
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to cilastatin or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinic or hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinic setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Doxepin

Abacavir

Diltiazem

Cyclosporine

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered only by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any undesired side effects to the doctor immediately.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine prevents the breakdown of imipenem in the kidneys and thus increases its effectiveness.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Dehydropeptidase inhibitor

Schedule

Schedule H

Cilastatin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 11 April 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/6435415#section=2D-Structure

Cilastatin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 11 April 2018]. Available from:

https://www.drugbank.ca/drugs/DB01597

[Internet]. Accessdata.fda.gov. 2018 [cited 11 April 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050587s074lbl.pdf

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Information on this page was last updated on 30 Apr 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.