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Cilacar C 6.25 Tablet

Manufactured byJB CHEMICALS AND PHARMACEUTICALS LTD
ContainsCilnidipine (10 mg) + Chlorthalidone (6.25 mg)
Description

Cilacar C 6.25 Tablet is a combination medicine used for the treatment of high blood pressure. Frequent monitoring of blood pressure and electrolytes level is necessary while taking this medicine. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect.

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Side effects

Major & minor side effects for Cilacar C 6.25 Tablet

  • Low blood pressure (hypotension)
  • Dizziness
  • Fast heartbeat
  • Muscle pain
  • Shaking of hands or feet
  • Skin rash
  • Decreased sexual urge
  • Increased urination frequency
  • Stomach pain
  • Photosensitivity
  • Constipation
  • Diarrhea
  • Loss of appetite
  • Nausea
  • Vomiting
  • Headache
  • Blurred vision
  • Restlessness

Uses of Cilacar C 6.25 Tablet

What is it prescribed for?

  • Hypertension (increased blood pressure)
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 2 to 6 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of dizziness, fainting, and very low blood pressure levels. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to cilnidipine, chlorthalidone or any other inactive ingredients present in the formulation.

Heart diseases

This medicine is not recommended for use in patients having heart conditions like heart attack, rhythm disorders, angina, narrowing of blood vessels etc. due to the increased risk of worsening of the patient's condition.

Anuria

This medicine is not recommended for use in patients with anuria (a condition where the kidney is unable to produce urine) due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (CrCl < 30 ml/min) due to the increased risk of serious adverse effects.

Severe liver impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Hypotension

This medicine should be used with caution in patients with severe aortic stenosis as it may lower the blood pressure because of the gradual onset of action. Inform the doctor if you experience any undesired effects.

Heart attack

This medicine should be used with caution while starting or increasing the dose in patients with coronary artery diseases as it may worsen the symptoms of heart attack.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Liver Disease

This medicine should be used with extreme caution in patient's suffering from liver diseases due to an increase in the risk of serious adverse effects. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Volume and electrolyte disturbances

This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Driving or operating machinery

Use of this medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating heavy machinery during treatment with this medicine if you experience any of these symptoms.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of dizziness, fainting, and very low blood pressure levels. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms.
Interaction with Medicine

Carbamazepine

Cisapride

Lithium

Amiodarone

Insulin

Cimetidine

Ziprasidone

Disease interactions

Hypotension or cardiogenic shock

This medicine is not recommended for use in patients suffering from a cardiogenic shock (a condition where the heart cannot pump enough blood) due to the increased risk of worsening of the patient’s condition. Replacement with a suitable alternative may be necessary based on the clinical condition.

Congestive heart failure

This medicine should be used with caution in patients who have suffered a heart attack recently due to the increased risk of worsening of the patient's condition. Suitable dose adjustment and safety monitoring may be required in such cases. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Diabetes

This medicine should be used with caution in patients with diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with hyperuricemia (increased uric acid levels in the blood) since this medicine decreases the uric acid excretion and increase the risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperlipidemia

This medicine should be used with caution in patients with hyperlipidemia since it may increase the cholesterol and triglyceride levels. Close monitoring of cholesterol and triglyceride levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as dizziness, headache, swelling of hands and feet, etc.
Lab interactions

Urinary vanillylmandelic acid

Report the use of this medicine if you have been asked to undergo this test for the presence of adrenal gland tumor. Use of this medicine is likely to give a false value that might be higher than normal.
Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Chlorthalidone works by increasing the excretion of water and sodium from the kidneys. This helps in bringing down the blood pressure as well as swelling (edema). Cilnidipine acts by blocking the influx of calcium (responsible for contraction of blood vessels) and causes relaxation, thereby promoting the smooth flow of blood. Thus, this combination medicine is better effective in treating high blood pressure.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Thiazide diuretics, Calcium channel blocking agents

Schedule

Schedule H

K. Sarat Chandra G. The fourth-generation Calcium channel blocker: Cilnidipine [Internet]. PubMed Central (PMC). 2017 [cited 23 March 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905258/

Cilnidipine | C27H28N2O7 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 23 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/cilnidipine#section=Top

Chlorthalidone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 19 October 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682342.html

Chlorthalidone - DrugBank [Internet]. Drugbank.ca. 2017 [cited 19 October 2017]. Available from:

https://www.drugbank.ca/drugs/DB00310
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Information on this page was last updated on 22 Apr 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.