Chlorthalidone

Description

Chlorthalidone is a diuretic used for the treatment of high blood pressure, edema, and heart failure. It should be used with caution in patients with kidney and liver diseases. Frequent monitoring of blood pressure and electrolytes level is necessary while taking this medicine. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect.

Side effects

Major & minor side effects for Chlorthalidone

  • Hypotension
  • Photosensitivity
  • Constipation
  • Diarrhea
  • Loss of appetite
  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Blurred vision
  • Restlessness

Uses of Chlorthalidone

What is it prescribed for?

  • Hypertension
  • Edema
  • Heart Failure
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 2 to 6 hours of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 24 to 72 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment this medicine due to the increased risk of dizziness, fainting, and a very low blood pressure. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to chlorthalidone or other sulfonamides.

Anuria

This medicine is not recommended for use in patients with anuria, a condition where the kidney is unable to produce urine.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (CrCl < 30 ml/min) due to the increased risk of serious adverse effects.

Severe liver impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Liver impairment

This medicine should be used with extreme caution in patient's suffering from liver diseases due to an increase in the risk of serious adverse effects. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Volume and electrolyte disturbances

This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Renal impairment

This medicine should be used with caution in patients with a known history of renal diseases due to the increased risk of worsening of the patient's condition. Close monitoring of renal function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Driving or operating machines

This medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating heavy machinery during treatment with this medicine if you experience any of these symptoms.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment this medicine due to the increased risk of dizziness, fainting, and a very low blood pressure. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Cisapride

Lithium

Amiodarone

Insulin

Ziprasidone

Disease interactions

Diabetes

This medicine may increase the blood glucose levels in patients with diabetes. Close monitoring of blood glucose levels is necessary for such patients. Suitable dose adjustments may be required based on the clinical condition of the patient.

Hyperuricemia

This medicine should be used with caution in patients with hyperuricemia since this medicine decreases the uric acid excretion. This may cause serious side effects. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Hyperlipidemia

This medicine should be used with caution in patients with hyperlipidemia since it may increase the cholesterol and triglyceride levels. Close monitoring of cholesterol and triglyceride levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as advised by your doctor. Do not take in larger amounts than prescribed. Take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by increasing the excretion of water and sodium from the kidneys. This helps in bringing down the blood pressure as well as swelling.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Thiazide diuretics

Schedule

N/A

Chlorthalidone - DrugBank [Internet]. Drugbank.ca. 2017 [cited 19 October 2017]. Available from:

https://www.drugbank.ca/drugs/DB00310

DailyMed - Chlorthalidone tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 19 October 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=193c85ba-43c2-4be2-82cf-7b394a83390e

Chlorthalidone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 19 October 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682342.html

[Internet]. 2017 [cited 19 October 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.29309.latest.pdf

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Information on this page was last updated on 30 Oct 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.