Chlorpropamide

Description

Chlorpropamide is an oral hypoglycemic agent used in the treatment of type 2 diabetes to control the blood sugar levels. It may be used in combination with other anti-diabetic medicines. Patients are advised to follow strict diet and exercise regimens along with this medicine to get the best possible effect.

Side effects

Major & minor side effects for Chlorpropamide

  • Hypoglycemia
  • Dizziness
  • Headache
  • Lethargy
  • Hemolytic anemia (G6PD deficiency)
  • Nausea and Vomiting
  • Dark colored urine
  • Decreased urine output
  • Muscle pain
  • Confusion
  • Swelling of face, ankles and hands
  • Indigestion
  • Weight loss
  • Scaly skin
  • Itching
  • Irregular heartbeat
  • Lightheadedness
  • Unusual sweating

Uses of Chlorpropamide

What is it prescribed for?

  • Type 2 diabetes
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is 1 hour.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is 24 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with Chlorpropamide due to the increased risk of both low as well as high blood sugar levels. If your diabetes is controlled, moderate consumption of alcohol does not affect sugar levels. However, it is advised that you consult your doctor about all the potential risks and benefits of consuming alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. If the medicine is used, close monitoring of the infant for any undesired side effects is necessary.

Allergy

This medicine is not recommended for use in patients with a known allergy to chlorpropamide.

Type I Diabetes mellitus

This medicine is not recommended for use in patients with type 1 diabetes mellitus.

Diabetic ketoacidosis

This medicine is not recommended for use in patients with diabetic ketoacidosis, a life-threatening complication of diabetes mellitus.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. If the medicine is used, close monitoring of the infant for any undesired side effects is necessary.
General warnings

Hemolytic anemia

This medicine should be used with extreme caution in patients with glucose 6-phosphate dehydrogenase deficiency due to the increased risk of hemolytic anemia. Replacement with a suitable alternative should be considered based on the clinical condition of the patient.

Hypoglycemia

This medicine may cause hypoglycemia. Seek immediate medical help if you experience a headache, dizziness, drowsiness, weakness, tremor, or nausea. Appropriate dose adjustments may be necessary based on your clinical condition.

Missed Dose

If a dose of Chlorpropamide is missed, take the dose as soon as you remember it. If it is almost time for the next dose, skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Chlorpropamide due to the increased risk of both low as well as high blood sugar levels. If your diabetes is controlled, moderate consumption of alcohol does not affect sugar levels. However, it is advised that you consult your doctor about all the potential risks and benefits of consuming alcohol during treatment with this medicine.
Interaction with Medicine

Chloramphenicol

Gatifloxacin

Miconazole

Beta blockers

Probenecid

Disease interactions

Cardiovascular disease

This medicine should be used with caution in patients with cardiovascular diseases since it may increase the risk of cardiovascular mortality. Close monitoring of heart function is recommended for such patients. An alternative treatment option should be considered based on the clinical condition.

Diabetic Ketoacidosis

This medicine is not recommended for use in patients with diabetic ketoacidosis. An alternative treatment option should be considered based on the clinical condition.

Renal and/or Liver diseases

This medicine should be used with caution in patients with renal and/or liver diseases. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Hypoglycemia

This medicine should be used with extreme caution in patients who are susceptible to hypoglycemia and patients on other anti-diabetic medications or beta-blockers. Close monitoring of blood glucose levels may be necessary based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Chlorpropamide exactly as instructed by the doctor. Do not take larger amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. You should always carry a sugar candy with you to overcome unexpected lowering of blood sugar levels.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
Chlorpropamide works by lowering the blood sugar levels in diabetic patients.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Sulfonylureas

Schedule

Schedule G

Chlorpropamide - DrugBank [Internet]. Drugbank.ca. 2017 [cited 7 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00672

Chlorpropamide: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 7 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682479.html

Diabinese (chlorpropamide) dosing, indications, interactions, adverse effects, and more [Internet]. Reference.medscape.com. 2017 [cited 7 August 2017]. Available from:

http://reference.medscape.com/drug/diabinese-chlorpropamide-342704

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 7 August 2017]. Available from:

http://www.tga.gov.au/prescribing-medicines-pregnancy-database

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Information on this page was last updated on 10 Aug 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.