Cefpodoxime

Description

Cefpodoxime is a cephalosporin antibiotic. It is used to treat bacterial infections in many different parts of the body. Cefpodoxime kills or stops the growth of bacteria causing the infection. It is not effective against infections caused by viruses. Common side effects of Cefpodoxime are diarrhoea, stomach pain, headache, weakness, nausea, and vomiting. Do not take this medicine if you are previously allergic to it. When Cefpodoxime is taken along with medications which reduce or prevent stomach acids like antacids, proton pump inhibitors or H2 blockers, it can delay Cefpodoxime actions on your body. Therefore, take this antibiotic at least 1 hour before or 2 hours after taking such medications. Cefpodoxime is available on prescription as a capsule, tablet, powder for suspension and syrup. Take the tablet form of this medication with food for good absorption and the suspension form with or without food. For the ease of remembering, take this medicine around the same time every day. Once an antibiotic is started, it is always recommended to finish the entire course of treatment. Cefpodoxime should only be used to treat or prevent infections that are caused by bacteria. Taking an antibiotic when it is not required can make it less effective for future infections.

Side effects

Major & minor side effects for Cefpodoxime

  • Diarrhoea
  • Stomach pain
  • Dark or clay coloured stools
  • Decreased appetite
  • Acid or sour stomach
  • Excessive gas in stomach
  • Nausea and vomiting
  • Skin rash
  • Headache
  • Dizziness

Uses of Cefpodoxime

What is it prescribed for?

  • Bronchitis
  • Cystitis
  • Gonorrhoea
  • Community-Acquired Pneumonia
  • Sinusitis
  • Pharyngitis/Tonsilitis
  • Skin and soft tissue infections
  • Acute bacterial otitis media
  • Pyelonephritis
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Concerns

Commonly asked questions

  • Onset of action
    The effect of cefpodoxime proxetil can be observed within 2 to 3 hours of administration. You will start to feel better in 3 to 5 days after taking cefpodoxime proxetil. But finish your entire course of treatment, even if your condition gets better.
  • Duration of effect
    The effect of cefpodoxime proxetil lasts for an average duration of 12 hours after the onset of action.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendency has been reported for Cefpodoxime.
  • Usage in pregnancy?
    Cefpodoxime is may be safe in pregnancy to treat bacterial infections. It is not known to cause birth defects when taken by pregnant women. Hence it is acceptable for use upon your doctor's recommendation.
  • Usage while breast-feeding?
    Cefpodoxime is may be safe to use during breastfeeding. It enters into breast milk in low levels. Hence it should only be used if the benefit is greater than the risk of harm to the baby. If used, the baby should be observed for symptoms such as diarrhoea and yeast infection.

Allergy

Avoid taking Cefpodoxime if you are previously allergic to it. Some patients may get allergic reactions to this medicine. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.
Warnings for special population

Pregnancy

Cefpodoxime is may be safe in pregnancy to treat bacterial infections. It is not known to cause birth defects when taken by pregnant women. Hence it is acceptable for use upon your doctor's recommendation.

Breast-feeding

Cefpodoxime is may be safe to use during breastfeeding. It enters into breast milk in low levels. Hence it should only be used if the benefit is greater than the risk of harm to the baby. If used, the baby should be observed for symptoms such as diarrhoea and yeast infection.
General warnings

Diarrhoea

Cefpodoxime can cause diarrhoea because it may also kill the helpful bacteria in your stomach or intestine. Get emergency medical help if you experience severe diarrhoea that is watery or bloody. Call your pharmacist/doctor before taking anti-diarrhoeal medication.

Seizures

Use Cefpodoxime with caution in patients with seizures or fits because it can trigger the condition. Seizure medicines should be continued in patients with a known seizure disorder. Dose adjustment for Cefpodoxime might be required in some patients.

Antibiotic resistance

Finish your entire course of treatment with Cefpodoxime, even if the condition gets better to avoid antibiotic resistance (the bacteria may become resistant to antibiotics). If you still feel unwell after completing your antibiotic course, make an appointment to consult your doctor.

Driving or operating machinery

Cefpodoxime may cause dizziness, confusion, or fits in some people. Do not drive a vehicle or operate machinery after taking this medicine.

Antacids

If you are taking an antacid containing aluminium and magnesium salts for indigestion, it can increase the time it takes for Cefpodoxime to act on your body. Because of this, it is recommended to take this antibiotic at least 1 hour before or 2 hours after taking antacids.

Missed Dose

Try not to skip a dose of Cefpodoxime. And if a dose is skipped, do not add it up to the next dose.

Overdose

Seek emergency medical attention in case of an overdose with Cefpodoxime.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Cholera Vaccine

Furosemide

Entecavir

Probenecid

Ethinyl Estradiol

Esomeprazole

Disease interactions

Colitis

Cefpodoxime can kill the helpful bacteria in your stomach or intestine and leads to diarrhoea. Therefore use Cefpodoxime with extreme caution in patients with gastrointestinal (mouth to anus) diseases, particularly colitis (swelling of the inner lining of the colon), since it may worsen the patient's condition.

Impaired kidney function

Cefpodoxime is filtered by the kidney and moved out of the body through urine. Patients with kidney diseases need special consideration while taking Cefpodoxime due to the risk of kidney damage. Dose adjustment should be done based on the clinical condition.

Impaired liver function

Cefpodoxime may increase liver enzyme levels and cause liver swelling. Patients with liver diseases need special consideration while taking Cefpodoxime due to the risk of liver damage. Dose adjustment should be done based on the clinical condition.
Food interactions
Taking Cefpodoxime before food may result in severe adverse effects. Therefore take this medicine with food to avoid any undesired side effects.
Lab interactions

Coombs test

A false-positive result may be obtained if this test is performed while taking Cefpodoxime.
What is cefpodoxime used to treat? Well, cefpodoxime is used to treat bacterial infections. Take the tablet form of cefpodoxime with food for good absorption and the suspension form with or without food. Never take more than the prescribed dose. Take this medicine at around the same time daily. Do not give your medicine to other people even if their condition appears to be the same as yours.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Cefpodoxime works by preventing the formation of bacterial cell walls. This helps in stopping the growth and multiplication of the microorganism, eventually killing it.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Third generation cephalosporins, Antibiotics

Schedule

Schedule H

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https://pubchem.ncbi.nlm.nih.gov/compound/Cefpodoxime>

Oraluxe.com. 2021. Oraluxe � Cefpodoxime � Antibiotics - Alpha Pharmaceuticals, Syria. [online] Available at: < [Accessed 5 January 2021].

http://www.oraluxe.com/cefpodoxime.htm>

Drugs, H., 2021. Cefpodoxime: Medlineplus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 5 January 2021].

https://medlineplus.gov/druginfo/meds/a698024.html>

Go.drugbank.com. 2021. Cefpodoxime | Drugbank Online. [online] Available at: < [Accessed 5 January 2021].

https://go.drugbank.com/drugs/DB01416>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 5 January 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/065462s005lbl.pdf>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 5 January 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/050674s015,050675s018lbl.pdf>

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Information on this page was last updated on 10 Feb 2021

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.