Cariprazine

Description

Cariprazine is an antipsychotic that is used for the treatment of schizophrenia (a brain disorder characterized by delusions, hallucinations, reduced speaking, etc.) and other mood disorders in adults. This medicine is not recommended for use in children.

Side effects

Major & minor side effects for Cariprazine

  • Blurred vision
  • Chills
  • Dizziness
  • Headache
  • Loss of balance
  • Muscle trembling, jerking, or stiffness
  • Restlessness
  • Bladder pain
  • Increased thirst
  • Weight gain
  • Sore throat
  • Double vision
  • Difficulty in speaking
  • Stomach upset
  • Skin rash, hives, or itching

Uses of Cariprazine

What is it prescribed for?

  • Schizophrenia
  • Bipolar I disorder
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, difficulty in concentration, impaired judgment, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit forming tendency has been reported
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Cariprazine or any other inactive ingredient present along with the formulation.

Severe liver impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of worsening of the patient's condition.

Severe kidney impairment

This medicine is not recommended for use in patients with severe kidney impairment due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Lipid alterations

This medicine may alter lipid levels in the body. Report any unusual symptoms to the doctor immediately. Close monitoring of lipid levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Weight gain

This medicine is likely to cause a gain in weight and hence periodic monitoring is required especially in patients who are obese.

Orthostatic hypotension

This medicine is likely to cause a position based decrease in blood pressure especially during the start of therapy. It should be given very carefully to patients who have an active disease of the heart and valves. Any condition leading to a decrease in blood pressure should be given consideration while deciding the dose.

Use in children

This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.

Use in elderly

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.

Driving or operating machinery

This medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms.

Hypersensitivity reactions

This medicine may cause hypersensitivity reactions such as skin rash, pruritus, urticaria, hives, angioedema (swelling of the tongue, lips, face, etc.) in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Suicidal thoughts

This medicine may increase the risk of suicidal thoughts in some patients. Patients should be monitored closely for any changes in behavior or mood. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, difficulty in concentration, impaired judgment, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Tramadol

Ciprofloxacin

Atenolol

Cimetidine

Zonisamide

Ketoconazole

Disease interactions

Tardive Dyskinesia

This medicine should be used with extreme caution in patients with tardive dyskinesia, a condition of involuntary repetitive body movements, since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate patient/caregiver education, close monitoring of the patient's condition, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Dementia

This medicine is not recommended for use in patients with dementia-related psychosis due to the increased risk of heart failure, pneumonia, death, etc. This risk is especially high in elderly patients. Replacement with a suitable alternative should be considered under your doctor's supervision.

Neuroleptic Malignant Syndrome (NMS)

This medicine should be used with extreme caution in patients with a known history of a neuroleptic malignant syndrome (NMS) due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Seizures

This medicine should be used with caution in patients with seizure disorders or central nervous system abnormalities due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Diabetes Mellitus

This medicine should be used with caution in patients with diabetes mellitus because it may alter the blood glucose levels in such patients. Close monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hypotension

This medicine should be used with caution in patients with hypotension (low blood pressure) due to the increased risk of worsening of the patient's condition. Close monitoring of blood pressure levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition. Patients should be advised to get up slowly from a sitting or a lying position to avoid fainting and falling.
Food interactions
Consumption of grapefruit and grapefruit juice during treatment with this medicine is not recommended due to the risk of severe side effects.
Lab interactions
Information not available.
Take this medicine exactly advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking this medicine before completion of the course/without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by binding to certain receptors and inhibits the release of the chemical substances that cause psychotic symptoms.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Atypical antipsychotics

Schedule

Schedule H

Cariprazine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 30 April 2020]. Available from:

https://medlineplus.gov/druginfo/meds/a615050.html

[Internet]. Medicines.org.uk. 2020 [cited 30 April 2020]. Available from:

https://www.medicines.org.uk/emc/files/pil.9487.pdf

[Internet]. Accessdata.fda.gov. 2020 [cited 30 April 2020]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/204370lbl.pdf

[Internet]. Ema.europa.eu. 2020 [cited 30 April 2020]. Available from:

https://www.ema.europa.eu/en/documents/product-information/reagila-epar-product-information_en.pdf

[Internet]. Vraylar.com. 2020 [cited 30 April 2020]. Available from:

https://www.vraylar.com/my-mood-matters

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Information on this page was last updated on 15 May 2020

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