Carbimazole

Description

Carbimazole is an anti-thyroid medicine used to treat hyperthyroidism. Hyperthyroidism is a condition that occurs due to excess production of thyroxine (a hormone produced in the thyroid gland). Carbimazole works by lowering the production of thyroxine. It is also used to relieve the symptoms of hyperthyroidism before radioactive iodine treatment or thyroid surgery. Carbimazole shows rapid weight loss as the most common side-effect. You may also experience other side effects like diarrhoea, joint pain, itching, skin rash, fever, headache, drowsiness, etc. Do not take this medicine if you are previously allergic to it. Contact your doctor if the side effects do not get better with time or worsen. Carbimazole have to be taken only on your doctor’s prescription. Carbimazole is not recommended for use in children below 2 years of age. Carbimazole can be taken with or without food. Your doctor will decide the dose of the medicine and how often you have to take them. Carbimazole is not recommended if you have a previous history of liver or haematological (blood) diseases. Regular monitoring of thyroid levels is necessary to observe the effectiveness of this medicine. Do not take Carbimazole without consulting your doctor if you are pregnant or breastfeeding.

Side effects

Major & minor side effects for Carbimazole

  • Sore throat
  • Mouth ulcers
  • Headache
  • Weakness
  • Rash
  • Fever
  • Itching
  • Nausea
  • Stomach irritation
  • Drowsiness
  • Testicular pain
  • Bone marrow toxicity

Uses of Carbimazole

What is it prescribed for?

  • Hyperthyroidism
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for Carbimazole to show its action is about 30-60 minutes.
  • Duration of effect
    The duration of time for which Carbimazole remains active in the body is about 20 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported for Carbimazole.
  • Usage in pregnancy?
    Carbimazole is not recommended if you are pregnant as it can cause serious foetal side effects. Consult your doctor before taking this medicine.
  • Usage while breast-feeding?
    Carbimazole is generally safe for use in breastfeeding women as very less or no amount of the medicine passes into breast milk. However, consult your doctor before taking this medicine.

Allergy

Do not take Carbimazole if you are previously allergic to it. Seek immediate medical attention if you notice any serious allergic reactions such as a skin rash, itching/swelling anywhere on your body, severe dizziness, breathing difficulty, etc.

Severe liver disease

Carbimazole is not recommended if you have severe liver disease. Patients with mild to moderate liver disease should maintain caution during the entire treatment course with Carbimazole.
Warnings for special population

Pregnancy

Carbimazole is not recommended if you are pregnant as it can cause serious foetal side effects. Consult your doctor before taking this medicine.

Breast-feeding

Carbimazole is generally safe for use in breastfeeding women as very less or no amount of the medicine passes into breast milk. However, consult your doctor before taking this medicine.
General warnings

Use in children

Carbimazoleis not recommended for use in children below 2 years of age since the safety and efficacy data is not available.

Bleeding disorders

Take Carbimazole with extreme caution if you have bleeding disorders. Close monitoring of prothrombin time/INR (blood tests to measure the time it takes for your blood to clot) is necessary while taking this medicine.

Surgeries

If you are planning to undergo any surgery during treatment with Carbimazole, close monitoring of prothrombin time is necessary as it can result in excessive bleeding.

Hypothyroidism

The use of Carbimazole for a prolonged period of time may result in hypothyroidism (low thyroid hormone levels). Therefore, it is necessary to regularly monitor your thyroid levels.

Liver diseases

Carbimazole can cause severe liver toxicity. Carbimazole is not recommended for use in patients with severe liver impairment. If you have liver disease, your liver function has to be regularly monitored.

Drowsiness

Carbimazole may cause dizziness or drowsiness. Do not perform any activity such as driving a vehicle or operating heavy machinery while on this medication.

Missed Dose

Try not to skip the scheduled dose of Carbimazole. However, if you forget to take a dose, take it as soon as you remember unless it is time for your next dose.

Overdose

Reach out to the nearest emergency medical department or contact your doctor in case of an overdose of Carbimazole.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Acenocoumarol

Digoxin

Theophylline

Disease interactions

Liver Disease

Use Carbimazole with extreme caution if you have liver disease as it may cause serious adverse effects and worsen your health condition. A frequent liver function test (LFT) is indicated.
Food interactions
Information not available.
Lab interactions
Information not available.
Carbimazole is used for treating hyperthyroidism. Take Carbimazole exactly as prescribed by your doctor. Your dose is likely to change over the course of treatment, based on your response and tolerance to this medicine. It may take several weeks for this medicine to start showing its effect. Do not stop using this medicine even when the symptoms resolve. Ensure that the course of treatment is completed.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Effect on sleep is not established

How it works
Carbimazole works by lowering the production of thyroxine.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Antithyroid agents

Schedule

Schedule H

Medicines.org.uk. 2021. [online] Available at: < [Accessed 14 July 2021].

https://www.medicines.org.uk/emc/files/pil.5025.pdf>

Pubchem.ncbi.nlm.nih.gov. 2021. Carbimazole. [online] Available at: < [Accessed 14 July 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Carbimazole>

Medsafe.govt.nz. 2021. [online] Available at: < [Accessed 14 July 2021].

http://www.medsafe.govt.nz/profs/Datasheet/n/Neo-Mercazoletab.pdf>

Apps.medicines.org.au. 2021. [online] Available at: < [Accessed 14 July 2021].

https://apps.medicines.org.au/files/ghpneome.pdf>

Effect of selenium on carbimazole-induced testicular damage and oxidative stress in albino rats. (2011). Journal of Trace Elements in Medicine and Biology, [online] 25(1), pp.59–66. Available at: [Accessed 29 Jul. 2021]. ‌

https://www.sciencedirect.com/science/article/abs/pii/S0946672X10000799

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Information on this page was last updated on 24 Aug 2021

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