Carbimazole

Description

Carbimazole is an anti-thyroid medicine. It is used to treat hyperthyroidism (an overactive thyroid gland). It is also used to relieve the symptoms of hyperthyroidism before radioactive iodine treatment or thyroid surgery. This medicine works by lowering the production of thyroxine. Carbimazole causes rapid weight loss as the most common side-effect. You may also experience other side effects like diarrhoea, joint pain, itching, skin rash, fever, headache, drowsiness, etc. These side effects may subside on their own. If they bother you for a longer time or worsen, consult your doctor. Avoid using this medicine if you are allergic to it.  Carbimazole can be taken with or without food. Take it at the dose and duration prescribed by your doctor. Do not take more than the recommended dose. Take it regularly at the same time for ease of remembering and for better results. Do not discontinue using this medicine without consulting your doctor.  Carbimazole may not be suitable for all people. It is not recommended for use in children below two years of age as the safety and efficacy data for use is not available. Inform your doctor if you have a low blood count and liver problems. Also, inform about all your other health issues and ongoing medications. Consult your doctor if you are pregnant or breastfeeding before taking this medicine.

Side effects

Major & minor side effects for Carbimazole

  • Sore throat
  • Mouth ulcers
  • Headache
  • Weakness
  • Rash
  • Fever
  • Itching
  • Nausea
  • Stomach irritation
  • Drowsiness
  • Testicular pain
  • Bone marrow toxicity

Uses of Carbimazole

What is it prescribed for?

  • Hyperthyroidism
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Concerns

Commonly asked questions

  • Onset of action
    Carbimazole starts showing its effect within 30-60 minutes of intake.
  • Duration of effect
    The duration of time for which Carbimazole remains active in your body is about 20 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported for Carbimazole.
  • Usage in pregnancy?
    Carbimazole is not recommended for use in pregnancy as it may harm your foetus. Hence, consult your doctor before taking this medicine.
  • Usage while breast-feeding?
    Carbimazole is generally safe for use during breastfeeding as very less or no amount of the medicine passes into breast milk. However, consult your doctor before taking this medicine.

Allergy

Avoid taking Carbimazole if you are allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Severe liver impairment

Carbimazole is not recommended if you have a severe liver problem. People with mild to moderate liver problems should exercise caution during the entire treatment course with Carbimazole.
Warnings for special population

Pregnancy

Carbimazole is not recommended for use in pregnancy as it may harm your foetus. Hence, consult your doctor before taking this medicine.

Breast-feeding

Carbimazole is generally safe for use during breastfeeding as very less or no amount of the medicine passes into breast milk. However, consult your doctor before taking this medicine.
General warnings

Use in children

Carbimazole is not recommended for use in children below two years of age as the safety and efficacy data are not available.

Bleeding disorders

Take Carbimazole with extreme caution if you have bleeding disorders. Your doctor may suggest tests to closely monitor your prothrombin time and INR (blood tests to measure the time it takes for your blood to clot) if necessary while taking this medicine.

Surgeries

Inform your doctor about the use of Carbimazole before undergoing any surgery, as it may lead to excessive bleeding.

Hypothyroidism

The use of Carbimazole for a prolonged period of time may result in hypothyroidism (low thyroid hormone levels). Therefore, it is necessary to regularly monitor your thyroid levels.

Liver disorder

Use Carbimazole with caution if you have a mild to moderate liver disorder. This medicine may not break down and accumulate in your body, leading to undesired side effects.

Low blood count

Use Carbimazole if you have a low blood count as it may worsen your condition. Your doctor may suggest a regular full blood count test if you have poor memory or confusion.

Driving vehicles and operating machines

Carbimazole may cause dizziness or drowsiness in some people. Hence, do not perform any activity such as driving vehicles or operating heavy machines if you are on this medication.

Serious side effects

Carbimazole may cause sore throat, mouth ulcer, fever, etc. Discontinue using this medicine and inform your doctor about these symptoms immediately. Your doctor may suggest tests to examine the white blood cells in your body.

Missed Dose

Do not skip any dose of Carbimazole. However, if you forget to take a dose, take it as soon as you remember unless it is time for your next dose. Do not double your dose to make up for the missed one.

Overdose

Never take more than the prescribed dose of Carbimazole. Seek emergency medical treatment in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Acenocoumarol

Digoxin

Theophylline

Disease interactions

Liver impairment

Use Carbimazole with extreme caution if you have liver problems, as it may cause serious side effects and worsen your health condition. Your doctor may suggest a liver function test if necessary while using this medication.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Carbimazole exactly as prescribed by your doctor. Your dose is likely to change over the course of treatment based on your response and tolerance to this medicine.  It may take several weeks for this medicine to start showing its effects. Do not stop using this medicine even when the symptoms resolve. Ensure that the course of treatment is completed. Keep out of reach of children and pets. Do not use it after the date of expiry. Ensure that unused medicine is disposed of properly.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Carbimazole works by lowering the production of thyroxine.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Antithyroid agents

Schedule

Schedule H

Pubchem.ncbi.nlm.nih.gov. 2021. Carbimazole. [online] Available at: < [Accessed 14 July 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Carbimazole>

Medsafe.govt.nz. 2021. [online] Available at: < [Accessed 14 July 2021].

http://www.medsafe.govt.nz/profs/Datasheet/n/Neo-Mercazoletab.pdf>

Apps.medicines.org.au. 2021. [online] Available at: < [Accessed 14 July 2021].

https://apps.medicines.org.au/files/ghpneome.pdf>

Effect of selenium on carbimazole-induced testicular damage and oxidative stress in albino rats. (2011). Journal of Trace Elements in Medicine and Biology, [online] 25(1), pp.59–66. Available at: [Accessed 29 Jul. 2021]. ‌

https://www.sciencedirect.com/science/article/abs/pii/S0946672X10000799

Medicines.org.uk. 2021. Carbimazole 10 mg Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 17 December 2021].

https://www.medicines.org.uk/emc/product/10328/smpc#MACHINEOPS>

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Information on this page was last updated on 21 Jan 2022

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.