Capreomycin

Description

Capreomycin is an antibiotic used in a combination with other antitubercular medicines for the treatment of Mycobacterium tuberculosis. It is generally used in patients who have acquired resistance to other anti-tubercular medicines or in case of toxicity with the use of other anti-tubercular medicines.

Side effects

Major & minor side effects for Capreomycin

  • Chest pain
  • Chills
  • Dizziness and Drowsiness
  • Difficulty in breathing
  • Fever
  • Nausea or Vomiting
  • Difficulty or painful urination
  • Sore throat
  • Unusual tiredness or weakness
  • Decrease/loss of hearing
  • Black or tarry stools

Uses of Capreomycin

What is it prescribed for?

  • Tuberculosis
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time required by this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the appropriate course of action based on your clinical condition as well as the risks and benefits involved.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the appropriate course of action based on your clinical condition as well as the risks and benefits involved.

Allergy

This medicine is not recommended for use in patients with a known allergy to capreomycin or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the appropriate course of action based on your clinical condition as well as the risks and benefits involved.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the appropriate course of action based on your clinical condition as well as the risks and benefits involved.
General warnings

Hepatic Impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Impairment

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hematological toxicities

This medicine should be used with caution in patients suffering from hematological toxicities such as leucocytosis and leucopenia due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hearing loss

This medicine may lead to loss of hearing on prolonged use in some patients and should be used with extreme caution in patients with hearing impairment, since it may worsen the existing condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Drug resistance

Usage of this medicine without sufficient proof or suspicion of a mycobacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Extensively drug-resistant TB (XDR TB)

For patients suffering from XDR TB (extensively drug-resistant TB), your doctor will determine the suitability of Capreomycin use as well as the use of other medicines based on your clinical condition and therapeutic response.

Missed Dose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Live cholera vaccine

Neomycin

Amikacin

Ziprasidone

Tacrolimus

Gentamicin

Netilmicin

Kanamycin

Disease interactions

Renal impairment

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions

Liver function tests

Use of this medicine may alter the results of liver function tests in some patients. Inform your healthcare provider about the use of this medicine prior to undergoing the test.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by interfering with certain processes that help the bacteria to grow and increase in number; this ultimately leads to the death of the bacteria.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Streptomyces derivatives

Schedule

Schedule H1

Capreomycin Injection - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 18 December 2018]. Available from:

https://www.medicines.org.uk/emc/product/6192/smpc

[Internet]. Accessdata.fda.gov. 2018 [cited 18 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050095s062lbl.pdf

Capreomycin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 18 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Capastat

Capreomycin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 18 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00314

How will this medicine affect me?

Consult top doctors online and get an answer now
Chat now

Looking for a doctor?

Book an appointment with the top doctors near you
Book now
Something doesn’t feel right?
Report an error

Information on this page was last updated on 18 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.