Calcium Polystyrene Sulfonate

Description

Calcium Polystyrene Sulfonate is used for reducing blood levels of potassium. It is used for the treatment of hyperkalemia (high potassium levels) associated with kidney conditions such as anuria, severe oliguria, chronic kidney disease, etc. It is also used to reduce high potassium levels in patients who are undergoing regular dialysis.

Side effects

Major & minor side effects for Calcium Polystyrene Sulfonate

  • Gastric irritation
  • Weight loss
  • Nausea and vomiting
  • Constipation
  • Diarrhea
  • Severe abdominal pain
  • Presence of blood in stool
  • Unusual tiredness or weakness
  • Numbness or tingling in the hands, feet, or lips
  • Cramps and muscle spasm
  • Blistering and peeling of skin
  • Swelling of the face, arms, hands, lower legs, or feet
  • Difficulty in breathing
  • Difficulty in swallowing

Uses of Calcium Polystyrene Sulfonate

What is it prescribed for?

  • Hyperkalemia
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Concerns

Commonly asked questions

  • Onset of action
    The effects of this medicine can be observed within 1 to 2 hours of administration.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to calcium polystyrene sulfonate, any polystyrene sulfonate resins, or any other inactive ingredients present in the formulation.

Hypokalemia

This medicine is not recommended for use in patients with low blood potassium levels (less than 5 mmol/L) since it will worsen the patient's condition.

Hypercalcemia

This medicine is not recommended for use in patients with high levels of calcium in the blood (hypercalcemia) since it will worsen the patient's condition. It is also not recommended for use in patients suffering from conditions such as hyperparathyroidism, multiple myeloma, sarcoidosis, metastatic carcinoma, etc. that could elevate the blood calcium levels.

Bowel obstruction

This medicine is not recommended for use in patients with an obstructive disease of the gastrointestinal tract due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.
General warnings

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you report all your current medicines, including any herbs and supplements, to the doctor before beginning treatment with this medicine.

Chronic constipation

This medicine is not recommended for use in patients suffering from chronic constipation since it may worsen the patient's condition and cause severe adverse effects. Replacement with a suitable alternative should be considered based on the patient's clinical condition.

Gastro-intestinal blockage

This medicine is not recommended for use in patients with blockages or foldings of the gastrointestinal tract since it may worsen the patient's condition and cause severe adverse effects. Replacement with a suitable alternative should be considered based on the patient's clinical condition.

Severe depletion of potassium

Use of this medicine may cause a severe reduction in blood potassium levels, especially if the patient is taking digoxin. Administration of this medicine should be stopped if the serum potassium levels fall to 5 mmol/liter.

Electrolyte disturbances

Use of this medicine may cause abnormal levels of calcium and magnesium in the blood, which may cause severe adverse effects. Patients should be monitored for all applicable electrolyte disturbances during therapy with this medicine.

Administration of other medicines

This medicine may bind with other orally administered medicines which could decrease their effect or cause side effects. Hence, this medicine should be administered at least 3 hours before or 3 hours after other medicines administered orally. A time duration of 6 hours should be maintained between the administration of this medicine and other oral medicines in case a patient is suffering from gastroparesis or delayed stomach emptying.

Use in neonates

The oral form of this medicine should not be given to neonates. The rectal form is the preferred dosage form for neonates.

Missed Dose

Take/administer the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Antacids containing calcium/magnesium/aluminum

Levo-Thyroxine (Synthetic)

Digoxin

Lithium

Sorbitol

Disease interactions

Heart rhythm disorders

This medicine should be used with caution in patients with a pre-existing heart rhythm disorder since it may worsen the patient's condition. Close monitoring of heart rhythm is recommended in these patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

Sarcoidosis

This medicine should be used with extreme caution in patients suffering from sarcoidosis due to the increased risk of elevated blood calcium levels and associated severe adverse effects. This medicine should be used in such patients only if absolutely necessary. Replacement with a suitable alternative should be considered based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take/administer this medicine exactly as prescribed by the doctor. Your dose regimen is specifically determined based on the electrolyte levels in the blood. Do not take in larger or smaller quantities than recommended. Report any unusual symptoms to the doctor immediately. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine reduces blood levels of potassium.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Cation exchange resin

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2018 [cited 24 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.1439.pdf

[Internet]. Products.sanofi.ca. 2018 [cited 24 September 2018]. Available from:

http://products.sanofi.ca/en/resonium-calcium.pdf

[Internet]. Medsafe.govt.nz. 2018 [cited 24 September 2018]. Available from:

http://www.medsafe.govt.nz/profs/Datasheet/c/CalciumResoniumpowd.pdf

Calcium polystyrene sulfonate [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 24 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/169893#section=Top

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Information on this page was last updated on 27 Sep 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.