Calcitriol

Description

Calcitriol is a synthetic analogue of vitamin D which helps in regulating the absorption of calcium and its utilization in the body. It is used in the treatment of hypocalcemia, hypoparathyroidism, secondary hyperparathyroidism, renal osteodystrophy, etc.

Side effects

Major & minor side effects for Calcitriol

  • Abdominal pain
  • Vomiting
  • Rash
  • Headache
  • Decreased appetite
  • Metallic taste

Uses of Calcitriol

What is it prescribed for?

  • Hypocalcemia (low blood calcium levels)
  • Renal Osteodystrophy (calcium deficiency in kidney disease)
  • Hypoparathyroidism
  • Secondary Hyperparathyroidism
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 2-6 hours of oral administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 3-5 days.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to calcitriol or any other inactive ingredients present in the formulation.

Hypercalcemia

This medicine is not recommended for use in patients with hypercalcemia or evidence of vitamin D toxicity due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.
General warnings

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Liver/Kidney Disease

This medicine should be used with caution in patients with liver/kidney diseases due to the increased risk of adverse effects. Regular monitoring of liver/kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Oral form: Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one. Injection: Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Oral form: Seek emergency medical treatment or contact the doctor in case of an overdose. Injection: Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Iloperidone

Idelalisib

Axitinib

Dabrafenib

Ivosidenib

Apalutamide

Disease interactions

Arrhythmias

This medicine should be used with caution in patients with arrhythmia due to the increased risk of worsening of the patient's condition. Close monitoring of cardiac function and electrolyte levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Electrolyte imbalance

This medicine should be used with caution in patients with phosphate imbalance due to the increased risk of calcium phosphate deposits within renal or vascular systems or other soft tissue calcifications. Regular monitoring of electrolyte levels, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Regular monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Oral form: Take this medicine with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine before completion of the course/without consulting your doctor. Injection: This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It helps in the absorption of calcium in the body from foods or supplements. It also regulates the levels of parathyroid hormone.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Vitamins

Schedule

Schedule H

DailyMed - CALCITRIOL- calcitriol capsules 0.25 mcg capsule [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 13 September 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bebefb2a-7365-48e2-9681-83ed4b41e26e

Rocaltrol 0.25mcg capsules - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2019 [cited 13 September 2019]. Available from:

https://www.medicines.org.uk/emc/product/1115/smpc

Calcitriol - DrugBank [Internet]. Drugbank.ca. 2019 [cited 13 September 2019]. Available from:

https://www.drugbank.ca/drugs/DB00136

[Internet]. Accessdata.fda.gov. 2019 [cited 13 September 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/1998/21068lbl.pdf

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Information on this page was last updated on 16 Sep 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.