Calcipotriol

Description

Calcipotriol is a synthetic vitamin D derivative used for the treatment of plaque psoriasis in adults and children above 6 years of age. It may be used alone or in a combination with other medicines.

Side effects

Major & minor side effects for Calcipotriol

  • Excessive tiredness and weakness
  • Mental confusion
  • Loss of appetite
  • Mild to moderate depression
  • Nausea or vomiting
  • Constipation
  • Itching and skin rash
  • Difficulty in breathing
  • Swelling and redness at the application site
  • Burning or stinging sensation
  • Increased thirst
  • Increased urination frequency
  • Darkening of skin
  • Dandruff formation
  • Infection in the hair follicle
  • Dry mouth
  • Change in taste/ Metallic taste

Uses of Calcipotriol

What is it prescribed for?

  • Plaque Psoriasis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time taken by this medicine to show its effect is not clinically established. However, its effect is believed to be cumulative and improvement in symptoms is usually observed within 2 weeks of application.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine. If the medicine is used, monitor the infant closely for any undesired side effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to calcipotriol or any other inactive ingredient present in the formulation.

Calcium metabolism disorder

This medicine is not recommended for use in patients suffering from calcium metabolism disorders, resulting in higher or lower than normal levels of calcium in the body.

Severe liver/kidney damage

This medicine is not recommended for use in patients suffering from a severe impairment of liver or kidney function.

Use on face

This medicine is not recommended for use on the face.

Use in children below 6 years of age

This medicine is not recommended for use in children less than 6 years of age.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine. If the medicine is used, monitor the infant closely for any undesired side effects.
General warnings

Other medicines

This medicine may interact with other medicines and may cause severe adverse effects. Hence, it is advised that you report all your current medicines, including any herbs and supplements, to the doctor before beginning treatment with this medicine.

Ultraviolet radiation treatment

This medicine should be used with extreme caution in patients receiving ultraviolet radiation treatment for psoriasis due to the increased risk of skin cancer. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Use in elderly

This medicine should be used with caution in the elderly patients since the risk of adverse effects is significantly higher. Appropriate dose adjustments may be necessary based on the clinical condition of the patient.

Use in children

This medicine is not recommended for use in children less than 6 years of age since the safety and efficacy of use are not clinically established. It should be used with extreme caution in children above 6 years of age since the risk of adverse effects is significantly higher. Your doctor will suggest appropriate dose adjustments to minimize the risk of side effects.

Use on the face

This medicine should not be applied on the face since severe itching, redness, or irritation may develop. Patients are advised to take precautions so that the medicine does not come into contact with the eyes or the face.

Hypercalcemia

This medicine should not be used in patients suffering from hypercalcemia (elevated blood calcium levels) or patients with an evidence of vitamin D toxicity since it may worsen the patient's condition.

Exposure to sunlight

Patients are advised to avoid excessive exposure to sunlight (natural and artificial both) during treatment with this medicine. Appropriate precautionary measures should be taken while stepping outside at daytime.

Missed Dose

Apply the missed dose as soon as possible. If it is almost time for the next scheduled application, then the missed dose can be skipped. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

calcium supplements

Calcium salts

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Apply this medicine exactly as prescribed by the doctor. Do not use in smaller or larger quantities than recommended. Avoid contact with the eyes or face. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by slowing down the excessive production of skin cells.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Topical antipsoriatics

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2018 [cited 17 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.981.pdf

Calcipotriene [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 17 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Calcipotriol#section=Top

Calcipotriol - DrugBank [Internet]. Drugbank.ca. 2018 [cited 17 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB02300

DailyMed - Calcipotriene cream [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 17 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7ec750f6-26ea-46bc-aa7b-174fd25253a2

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Information on this page was last updated on 18 Sep 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.