Brimonidine

Description

Brimonidine is available in both ophthalmic and topical forms. The ophthalmic form of this medicine is used for the treatment of increased fluid pressure inside the eyes (intraocular pressure) and open-angle glaucoma, a condition which may lead to eventual vision loss. The topical form of this medicine is used to reduce the symptoms of rosacea, a skin condition characterized by symptoms such as facial redness, dilated or swollen blood vessels on the skin, skin rash, pimples, oily skin, etc.

Side effects

Major & minor side effects for Brimonidine

  • Headache
  • Dizziness
  • Blurred vision
  • Ocular irritation
  • Dry eyes
  • Conjunctivitis
  • Erythema
  • Skin itch
  • Skin burning sensation
  • Flushing
  • Acne
  • Dry skin

Uses of Brimonidine

What is it prescribed for?

  • Intraocular hypertension
  • Open angle Glaucoma
  • Rosacea
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Concerns

Commonly asked questions

  • Onset of action
    Ophthalmic use: The peak effect of this medicine can be observed within 2 hours of administration of the dose. Topical use: The effect of this medicine can be observed within 3 hours of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 12 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to brimonidine or any other inactive ingredients present along with this medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

Contact lens

The ophthalmic form of this medicine is not recommended for use if you are wearing soft contact lenses in your eyes. The lens should be removed prior to instillation and can be reinserted 15 minutes post instillation of this medicine.

Driving or Operating the machines

The ophthalmic use of this medicine may cause blurred vision, dizziness, or drowsiness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Bacterial Keratitis

If the ophthalmic solution of this medicine is contaminated by bacteria, it can lead to an infection of the cornea (bacterial keratitis). Patients are advised to take all hygienic precautions to ensure that the medicine is not contaminated.

Topical form of the medicine

The topical form of this medicine is not recommended for ophthalmic or intravaginal use due to the increased risk of serious adverse effects.

Depression

This medicine should be used with caution in patients suffering from depression due to the increased risk of worsening of the patient's condition. These patients should be monitored closely for any changes in mood or behavior. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Cardiovascular diseases

This medicine should be used with caution in patients with cardiovascular diseases due to the increased risk of a very low blood pressure. Report any symptoms such as dizziness, fainting, changes in heart rate, etc. to the doctor immediately. Close monitoring of vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Use in pediatrics

The topical form of this medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established. The ophthalmic form of this medicine is contraindicated for use in children below 2 years of age since the safety and efficacy of use are not clinically established. It is not recommended for use in patients below 18 years of age; however, your doctor may prescribe it in certain specific conditions where the benefits significantly outweigh the risks. In such cases, the patient should be monitored closely for any side effects and the side effects should be reported to the doctor immediately.

Missed Dose

The missed dose should be administered/applied as soon as possible. It is advisable to skip the missed dose if it is almost time for your next scheduled dose. Do not instill/apply a double dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Antihypertensives

Monoamine oxidase inhibitors

CNS depressants

Disease interactions

Depression

This medicine should be used with caution in patients suffering from depression due to the increased risk of worsening of the patient's condition. This risk is especially higher if the medicine is used for a prolonged period of time. Close monitoring of such patients for any change in mood or behavior is recommended. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Ophthalmic use: Use this medicine as per the instructions on the label or the package insert. Do not instill in larger amounts than prescribed. Seek emergency medical treatment in case of any side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. If you are using any other eye drops, maintain a time gap of at least 5 to 10 minutes between the administration of the two eye drops. Topical use: Apply a thin layer of the gel to the affected area as instructed by the doctor. Follow all the usage instructions mentioned on the label or the package insert. Do not apply in larger or smaller quantities than recommended. Do not cover the application area with bandages or other coverings unless specifically instructed by the doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Ophthalmic use: This medicine works by reducing the pressure inside the eyes. Topical use: This medicine constricts the blood vessels and reduces the symptoms of rosacea.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Alpha adrenergic agonists

Schedule

Schedule H

Brimonidine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 21 March 2018]. Available from:

https://www.drugbank.ca/drugs/DB00484

DailyMed - Brimonidine tartrate solution/ drops [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 21 March 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1ce6d79a-32c1-44dc-b50c-ada8848f39c3

Brimonidine Ophthalmic: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 21 March 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a601232.html

[Internet]. 2018 [cited 21 March 2018]. Available from:

https://www2.medicines.org.uk/emc/medicine/109

[Internet]. 2018 [cited 21 March 2018]. Available from:

https://www2.medicines.org.uk/emc/PIL.29410.latest.pdf

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2018 [cited 21 March 2018]. Available from:

http://www.tga.gov.au/prescribing-medicines-pregnancy-database

[Internet]. Accessdata.fda.gov. 2018 [cited 21 March 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020613s031lbl.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 21 March 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204708lbl.pdf

[Internet]. Galdermausa.com. 2018 [cited 21 March 2018]. Available from:

http://www.galdermausa.com/pi/mirvasopi.pdf

[Internet]. Pbm.va.gov. 2018 [cited 21 March 2018]. Available from:

https://www.pbm.va.gov/PBM/clinicalguidance/drugmonographs/Brimonidine_Gel_MIRVASO_Monograph.pdf

[Internet]. Allergan-web-cdn-prod.azureedge.net. 2018 [cited 21 March 2018]. Available from:

https://allergan-web-cdn-prod.azureedge.net/allergan/allergannewzealand/media/allergannewzealand/products/alphagan-p-nz-ds.pdf

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Information on this page was last updated on 26 Mar 2018

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.