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Bosentas 62.5 mg Tablet

Manufactured byCipla Ltd.
ContainsBosentan
Description

Bosentas 62.5 mg Tablet is an antihypertensive drug specifically used in the treatment of pulmonary arterial hypertension (PAH) (WHO class 1), a condition characterized by high blood pressure in the vessels carrying blood from the heart to the lungs. This medicine helps to prevent progression of the disease and improve exercise tolerance. Female patients are advised to undergo a pregnancy test to exclude pregnancy before beginning treatment with this medicine.

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Side effects

Major & minor side effects for Bosentas 62.5 mg Tablet

  • Hypersensitivity
  • Elevated liver enzymes
  • Unexplained weight loss
  • Fast/irregular heart beat
  • Blurred vision
  • Respiratory tract infection
  • Headache
  • Anemia
  • Swelling of ankles or feet
  • Hypotension

Uses of Bosentas 62.5 mg Tablet

What is it prescribed for?

  • Pulmonary arterial hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Hypersensitivity

This medicine is not recommended for use in patients with a known allergy to bosentan or any other components present along with it.

Pregnancy

This medicine is not recommended for use in pregnant women.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Liver impairment

This medicine is not recommended for use in patients with moderate to severe hepatic impairment due to the increased risk of worsening of the patient's condition.

Fluid overload

This medicine may cause an increased risk of edema in ankles and feet due to fluid overload. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Use in pediatrics

This medicine is not recommended for use in children and adolescents.

Infertility

This medicine may reduce sperm count in males. Discuss with your doctor all the risks and benefits before beginning treatment with this medicine.

Effect on hemoglobin and hematocrit

This medicine may decrease the hemoglobin and hematocrit levels in the blood. Regular monitoring of hemoglobin and hematocrit is recommended during treatment with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Effective contraception

Since Bosentas 62.5 mg Tablet may cause serious fetal harm, use of highly effective contraceptive methods is advised for females of reproductive potential while on treatment with this medicine and one month after stopping the therapy to avoid pregnancy.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Ranolazine

Leflunomide

Cyclosporine

Hydrocodone

Fentanyl

Medroxyprogesterone

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Bosentas 62.5 mg Tablet as instructed by the doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Bosentas 62.5 mg Tablet works by blocking the actions of endothelin 1, a natural substance responsible for pulmonary arterial hypertension.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Endothelin receptor antagonist, Vasodilators

Schedule

N/A

Toxnet [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 24 August 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~vVzpBf:4

Bosentan (substance) [Internet]. Snomedbrowser.com. 2017 [cited 24 August 2017]. Available from:

http://www.snomedbrowser.com/Codes/Details/385559004

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 24 August 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database

DailyMed - TRACLEER- bosentan tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 24 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=749e42fb-2fe0-45dd-9268-b43bb3f4081c

Bosentan: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 24 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a605001.html

Bosentan - DrugBank [Internet]. Drugbank.ca. 2017 [cited 24 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00559

[Internet]. 2017 [cited 24 August 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.32111.latest.pdf
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Information on this page was last updated on 9 Sep 2017

Disclaimer

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