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Biovorin 15 Tablet
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Biovorin 15 Tablet

Manufactured byBiochem Pharmaceutical Industries Ltd.
ContainsLeucovorin
Description
Biovorin 15 Tablet is a medicine that contains Leucovorin. It is used to prevent the harmful effects of methotrexate (anticancer medicine). It is also used in the treatment of methotrexate overdose. It also increases the effectiveness of certain anti-cancer medicines such as 5-fluorouracil. This medicine works by protecting healthy cells from the toxic effects of methotrexate. Biovorin 15 Tablet is generally a safe medicine with no common side effects when used in the prescribed dosage. However, consult your doctor if you experience any undesirable effects after taking it. Do not take this medicine if you are allergic to it. Biovorin 15 Tablet can be taken with or without food. Take this medicine in the dose and for the duration prescribed by your doctor. Follow all the instructions given by your doctor and do not take more than the prescribed dose. Your doctor may suggest regular blood tests to monitor your blood cells and serum methotrexate concentration in your blood. Biovorin 15 Tablet may not be suitable for all people. Inform your doctor if you have Vitamin B12 deficiency and any other health issues. Also, inform your doctor about all your ongoing medicines before taking this medicine. If you are pregnant or are breastfeeding, inform your doctor before prescribing this medicine to you.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Biovorin 15 Tablet

  • Severe skin rash and hives
  • Swelling of the face, arms, hands, lower legs, or feet
  • Difficulty in breathing
  • Difficulty in swallowing
  • Fainting
  • Fever
  • Convulsions (seizures)
  • Agitation and anxiety
  • Indigestion
  • Difficulty in falling asleep
  • Peeling and blistering of skin
  • Constipation
  • Unusual tiredness or weakness

Uses of Biovorin 15 Tablet

What is it prescribed for?

  • Methotrexate rescue
  • Folic acid antagonist overdose
  • Megaloblastic anaemia
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of Biovorin 15 Tablet can be observed within 20 to 30 minutes of intake.
  • How long do the effects of this medicine last?
    The effect of Biovorin 15 Tablet lasts for an average duration of 3 to 6 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Biovorin 15 Tablet.
  • Can this medicine be taken during pregnancy?
    Biovorin 15 Tablet is not recommended for use in pregnancy unless necessary. Your doctor will weigh the benefits and the risks before prescribing this medicine to you.
  • Can this medicine be taken while breast-feeding?
    Biovorin 15 Tablet is not recommended for use in breastfeeding unless necessary. Hence, if you are breastfeeding, inform your doctor before taking this medicine.

Allergy

Avoid taking Biovorin 15 Tablet if you are allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Pernicious anaemia

Pernicious anaemia is a condition of low red blood cell count caused due to deficiency of Vitamin B12. Biovorin 15 Tablet is not recommended for use if you have Pernicious anaemia.
Warnings for special population

Pregnancy

Biovorin 15 Tablet is not recommended for use in pregnancy unless necessary. Your doctor will weigh the benefits and the risks before prescribing this medicine to you.

Breast-feeding

Biovorin 15 Tablet is not recommended for use in breastfeeding unless necessary. Hence, if you are breastfeeding, inform your doctor before taking this medicine.
General warnings

Other medicines

Biovorin 15 Tablet may interact with many other medicines and may cause severe side effects. Hence, it is advised that you report all your current medicines, including any herbs and supplements to your doctor before beginning treatment with this medicine.

Use in elderly

Use Biovorin 15 Tablet with caution in the elderly as the risk of side effects is high.

Seizure disorders

Seizures is a brain disorder that causes uncontrolled body movements, behaviour, and state of awareness. Use Biovorin 15 Tablet with caution if you have seizures disorder since it may worsen your condition. This risk is especially higher if higher doses of this medicine are used.

Missed Dose

Take the missed dose of Biovorin 15 Tablet as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Never take more than the prescribed dose. Seek emergency medical treatment in case of an overdose of Biovorin 15 Tablet is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Phenobarbital

Fluorouracil

Capecitabine

Trimethoprim

Ceftriaxone

Phenytoin

Methotrexate

Disease interactions

Undiagnosed anaemia

Anaemia is a condition of low red blood cells in your blood. It is not recommended to take Biovorin 15 Tablet for undiagnosed anaemia, as this medicine is not suitable for anaemia caused due to Vitamin B12 deficiency.

Seizures

Seizures is a brain disorder that causes uncontrolled body movements, behaviour, and state of awareness. Use Biovorin 15 Tablet with extreme caution if you have a history of seizures as it may worsen your condition. This risk is especially higher if higher doses of this medicine are used.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Biovorin 15 Tablet as prescribed by your doctor. Do not take more or fewer doses than prescribed. Do not stop the use of this medicine without consulting your doctor. Keep the medicine away from the reach of children and pets. Ensure that the unused medicine is disposed of properly.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Biovorin 15 Tablet protects healthy cells from the harmful effects of methotrexate. It is an analogue of folic acid and helps in the formation of red blood cells.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antidotes

Schedule

Schedule H

Medicines.org.uk. 2021. [online] Available at: < [Accessed 30 November 2021].

https://www.medicines.org.uk/emc/files/pil.1369.pdf>

Memorial Sloan Kettering Cancer Center. 2021. Leucovorin Calcium. [online] Available at: < [Accessed 30 November 2021].

https://www.mskcc.org/cancer-care/patient-education/leucovorin-calcium-01>

Drugs, H., 2021. Leucovorin: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 30 November 2021].

https://medlineplus.gov/druginfo/meds/a682336.html>
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Information on this page was last updated on 6 Dec 2021

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