Home >
Medicine Info >
Biduret-L Tablet
Loading interface...

Biduret-L Tablet

Manufactured byGLAXOSMITHKLINE PHARMACEUTICALS LTD
ContainsAmiloride (2.5 mg) + Hydrochlorothiazide (25 mg)
Description
Biduret-L Tablet is a combination medicine which may be used to treat high blood pressure, congestive heart failure, fluid retention with liver cirrhosis. This medicine should be used with caution in patients with liver and kidney disease. Frequent monitoring of blood pressure and electrolyte levels is necessary while taking this medicine. This medicine is not recommended for use in patients below 18 years of age.
QUICK LINKS:
Side effectsConcernsUsage

Side effects

Major & minor side effects for Biduret-L Tablet

  • Abdominal pain
  • Confusion
  • Difficulty in breathing
  • Nausea or Vomiting
  • Irregular heartbeat
  • Shortness of breath
  • Dizziness
  • Blurred vision
  • Fever
  • Headache
  • Constipation

Uses of Biduret-L Tablet

What is it prescribed for?

  • Hypertension
  • Congestive Heart Failure
  • Edema and/or ascites associated with liver cirrhosis
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 2 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of hypotension and adverse effects such as dizziness, fainting, lightheadedness, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to amiloride, hydrochlorothiazide, other sulfonamides, or any other inactive ingredients present in the formulation.

Anuria

This medicine is not recommended for use in patients with anuria (a condition where the kidney is unable to produce urine) due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (BUN > 30 mg/dL, Scr > 1.5 mg/dL) due to the increased risk of worsening of the patient's condition.

Hyperkalemia

This medicine is not recommended for use in patients with hyperkalemia (elevated blood levels of potassium in the body) due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Liver Disease

This medicine should be used with extreme caution in patient's suffering from liver diseases due to an increase in the risk of adverse effects. Close monitoring of liver function is advised while taking this medicine. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with a known history of renal diseases due to the increased risk of worsening of the patient's condition. Close monitoring of renal function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperkalemia

This medicine may increase potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (ACE inhibitors and potassium supplements) during treatment with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Volume and electrolyte depletion

This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of hypotension and adverse effects such as dizziness, fainting, lightheadedness, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
Interaction with Medicine

Deflazacort

Insulin

Nonsteroidal anti-inflammatory drugs

Angiotensin converting enzyme inhibitors (ACEI's)

Candesartan

Lithium

Disease interactions

Diabetes

This medicine should be used with caution in patients with diabetes due to the increased risk of hyperkalemia, which may result in life-threatening cardiac arrhythmias. Close monitoring of blood glucose levels, serum potassium levels, and renal function tests are necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Electrolyte imbalance

This medicine is not recommended for use in patients with electrolytes imbalance due to the increased risk of worsening of the patient's condition. Electrolytes levels should be corrected before starting the treatment with this medicine. Monitoring of potassium, sodium and other electrolytes levels is necessary while receiving this medicine. An alternative treatment option should be considered in some cases based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patient's suffering from liver diseases due to the increased risk of adverse effects. Close monitoring of liver function is advised while taking this medicine. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with extreme caution in patient's suffering from acute or progressive renal insufficiency, or diabetic nephropathy due to the increased risk of hyperkalemia, which may result in life-threatening cardiac arrhythmias. Close monitoring of renal function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with hyperuricemia since this medicine decreases the uric acid excretion and increase the risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. It is advised to take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by increasing the excretion of water and sodium from the kidneys. This helps in bringing down the blood pressure as well as swelling.
Legal Status

Unknown

Unknown

Unknown

Approved

Classification

Category

Potassium sparing diuretics with thiazides

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2019 [cited 4 April 2019]. Available from:

https://www.medicines.org.uk/emc/product/2372/smpc

[Internet]. Dailymed.nlm.nih.gov. 2019 [cited 4 April 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8b2c581a-f955-4a8e-bf85-e768e903fd10

Amiloride and Hydrochlorothiazide: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 4 April 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a601014.html
Loading related questions...
Something doesn’t feel right?
Report an error

Information on this page was last updated on 30 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.