Azathioprine

Description

Azathioprine is an immuno-suppressant drug, which is used in rheumatoid arthritis and kidney transplant patients. It should be used under the supervision of a qualified physician. Close monitoring of blood cell count is necessary while receiving this medication.

Side effects

Major & minor side effects for Azathioprine

  • Fever with chills
  • Sore throat
  • Abdominal pain
  • Loss of appetite
  • Muscle and joint pain
  • Nausea and Vomiting
  • Hair loss or thinning of the hair

Uses of Azathioprine

What is it prescribed for?

  • Kidney Transplantation
  • Rheumatoid Arthritis
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed in 1 to 2 hours.
  • Duration of effect
    The duration of action of this medicine is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for pregnant women.
  • Usage while breast-feeding?
    This medicine is not recommended in breastfeeding women.

Allergy

Not recommended in patients with known allergy to Azathioprine.

Alkylating agents

Not recommended in patients with rheumatoid arthritis previously treated with cyclophosphamide, chlorambucil.
Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women.

Breast-feeding

This medicine is not recommended in breastfeeding women.
General warnings

Malignancy

This medicine may increase the risk of lymphoma and other malignancies. Doctors should inform patients about these risks and advise the patient to prevent exposure of the sunlight by wearing protective clothes.

Blood cell count

This medicine may lower the blood cell count and may lead to a condition severe bone marrow suppression. Close monitoring of blood cell count is necessary. Any signs of decreased WBC and platelets should be informed to the doctor.

Serious infections

The chances of occurring infections are more in the patients receiving this medicine. Hold the treatment and start with the broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

Liver impairment

This medicine is not recommended in the patients with the liver impairment. The concentration of this medicine may increase in these patients. The baseline of the liver function tests should be obtained before starting the treatment.

Missed Dose

If you miss a dose of Azathioprine, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Warfarin

Angiotensin converting enzyme inhibitors

Live attenuated vaccines and related products

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Azathioprine as advised by your doctor. Do not take in larger amounts than advised. It is advised to take this medicine at the same time every day. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor.
Miscelleneous

To be taken after food

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by decreasing the body's immune system activity and helps in preventing rejection of transplanted organs.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Other immunosuppressant

Schedule

Schedule H

[Internet]. 2017 [cited 3 May 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/26877

Azathioprine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 3 May 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682167.html

DailyMed - Azathioprine tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 3 May 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=59f3219f-898f-4d05-a430-c2b3f5255af1

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 3 May 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 3 May 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~1TwkMH:1

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Information on this page was last updated on 16 Nov 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.