Azacitidine

Description

Azacitidine is a nucleoside metabolic inhibitor used for the treatment of the myelodysplastic syndrome, a group of cancers that affect the production of blood cells. This medicine is not recommended for use in patients below 18 years of age.

Side effects

Major & minor side effects for Azacitidine

  • Nausea and Vomiting
  • Dizziness
  • Chest pain
  • Difficulty in breathing
  • Fast heartbeat
  • Headache
  • Cough
  • Unusual tiredness or weakness
  • Bleeding gums
  • Blurred vision

Uses of Azacitidine

What is it prescribed for?

  • Myelodysplastic syndrome
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, the infant should be monitored closely for any undesired side effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to azacitidine or any other inactive ingredients present in the formulation.

Liver Tumours

This medicine is not recommended for use in patients suffering from advanced malignant liver tumors due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, the infant should be monitored closely for any undesired side effects.
General warnings

Anemia

This medicine should be used with caution in patients with anemia due to the increased risk of worsening of the patient's condition. Regular monitoring of complete blood picture, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Regular monitoring of kidney function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Regular monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Tumor lysis Syndrome

This medicine should be used with caution since it may increase the risk of tumor lysis syndrome. All the risks and benefits should be discussed with the doctor before receiving this medicine. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Women with child bearing potential

This medicine is not recommended for use in pregnant women unless absolutely necessary due to the increased risk of fetal harm. Female patients of child-bearing potential should always use at least 2 methods of reliable birth control to avoid pregnancy during treatment with this medicine. An alternative treatment option should be considered in some cases based on the clinical condition.

Missed Dose

Since this medicine is administered in the hospital or clinical setting by a qualified health care professional, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Leflunomide

BCG vaccine

Adalimumab

Clozapine

Disease interactions

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Regular monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Regular monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by enhancing the bone marrow for the production of normal blood cells. It also helps in killing the abnormal cells in the bone marrow.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Miscellaneous antineoplastics

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 21 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/050794s031lbl.pdf

[Internet]. Drugbank.ca. 2018 [cited 21 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00928

[Internet]. Medicines.org.uk. 2018 [cited 21 September 2018]. Available from:

https://www.medicines.org.uk/emc/product/6468/smpc#

[Internet]. Bioline.org.br. 2018 [cited 21 September 2018]. Available from:

http://www.bioline.org.br/pdf?ph05113

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Information on this page was last updated on 22 Aug 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.