Axiron 1000 MG Injection

Manufactured byBsp Pharmaceuticals Ltd.
ContainsCeftriaxone
Description

Axiron 1000 MG Injection is used to treat a variety of conditions such as urinary tract infections, infection of the ears, lungs and meningitis caused by bacteria. It should not be used with calcium-containing intravenous solutions.

Side effects

Major & minor side effects for Axiron 1000 MG Injection

  • Black or tarry stools
  • Chest pain
  • Fever
  • Difficulty or painful urination
  • Sore throat
  • Diarrhea
  • Abdominal pain
  • Dizziness
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Acid or sour stomach
  • Change in taste
  • Excessive air or gas in stomach

Uses of Axiron 1000 MG Injection

What is it prescribed for?

  • Bacterial Meningitis
  • Bacterial Septicemia
  • Gonococcal Infection
  • Urinary Tract Infection
  • Pneumonia
  • Bone and joint infections
  • Skin and structure Infection
Read More
Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine occurs rapidly after intravenous and intramuscular routes of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 24 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to ceftriaxone or any other Beta-lactam antibiotics such as penicillins or cephalosporins.

Lidocaine

Axiron 1000 MG Injection is contraindicated for use if Lidocaine is used as a solvent for intravenous injection. Lidocaine can be used as a solvent for the intramuscular route of injection for this medicine, despite contraindications.

Calcium-containing products

Axiron 1000 MG Injection is contraindicated in neonates who are on calcium-containing intravenous solutions or infusions such as parenteral nutrition because of the risk of precipitation of Axiron 1000 MG Injection and calcium.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
General warnings

Allergy

This medicine is not recommended for use in patients with a known history of allergy to ceftriaxone or Beta-lactam Antibiotics such as penicillins and cephalosporins.

Hemolytic anemia

An immune mediated hemolytic anemia has been reported in patients receiving Axiron 1000 MG Injection and other cephalosporins. Report any unusual symptoms to the doctor immediately. Your doctor may advise you to discontinue the medicine if you develop hemolytic anemia until the exact cause is determined.

Prothrombin time

Alterations in prothrombin time (a test used to check for bleeding problems) have been reported in patients receiving Axiron 1000 MG Injection. Regular monitoring of prothrombin time may be necessary for some patients. Replacement with a suitable alternative may be required in some cases based on the clinical condition.

Drug-resistance

Usage of Axiron 1000 MG Injection without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Patients with impaired kidney or liver function

This medicine should be used with caution in patients with kidney or liver diseases due to the increased risk of severe adverse effects. The dose of this medicine should not exceed 2 g/day for such patients.

Clostridium difficile-associated Diarrhea

This medicine is not recommended for use if you experience severe diarrhea after receiving Axiron 1000 MG Injection. Antibiotic therapy may cause an imbalance in the normal microbial flora in the large intestine; this may promote the growth of bacteria called Clostridium difficile, leading to severe diarrhea. Your doctor may prescribe a safer alternative based on your clinical condition.

Use in neonates

Use of Axiron 1000 MG Injection is not recommended in patients less than 28 days of age.

Missed Dose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amikacin

Ethinyl Estradiol

Cholera Vaccine

Cyclosporine

Disease interactions

Colitis

This medicine may cause diarrhea, abdominal pain and blood in stools in some cases. This risk is especially higher in patients with a history of gastrointestinal diseases. Drink an adequate amount of water to prevent dehydration. Report any such symptoms to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

Seizure disorders

This medicine should be used with caution in patients with a history of seizure disorder or a family history of seizures since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the hospital by a qualified healthcare professional. Carefully follow all the instructions given by your doctor. Report any unusual symptoms or side effects to the doctor immediately. Report any allergies to antibiotics to the doctor prior to using this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Axiron 1000 MG Injection works by interfering with certain processes that help the bacteria to grow and increase in number.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Third generation cephalosporins

Schedule

Schedule H

DailyMed - ceftriaxone- ceftriaxone sodium injection, powder, for solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 22 February 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2dd1be9e-74cc-48e8-bf02-f34a78d80fda

Ceftriaxone Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 22 February 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a685032.html

[Internet]. 2017 [cited 22 February 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/26465#PRODUCTINFO

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 22 February 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 22 February 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~fnJYzy:1
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